Protein Alignment IGF2R and Lerp

DIOPT Version :10

• Sequence 1: NP_000867.3
• Gene: IGF2R / 3482
• HGNCID: 5467
• Length: 2491
• Species: Homo sapiens
• Sequence 2: NP_001262996.1
• Gene: Lerp / 43223
• FlyBaseID: FBgn0051072
• Length: 918
• Species: Drosophila melanogaster
• Alignment Length: 795
• Identity: 208/795 - (26%)
• Similarity: 327/795 - (41%)
• Gaps: 114/795 - (14%)

Human  1215 EACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTI------VSAGEYTYYFRVCGKLSSDVCPTS 1273
            :|...::.....|::|:|.:|:.:|..  ||:..:      ::.|...:.|.:||.||.    |.
  Fly    43 DAANQLKFSTTECKLKEPIYGSTFDFS--GLHSDLAHVVKSMNIGGDQFEFNICGNLSR----TC 101

Human  1274 DKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTA--------IF 1330
            :....|::|.::   ||...:.| ...:|.|.||.:.:.:..|..|    ...||        :.
  Fly   102 NGESNVAACLKR---QGKEYILG-RQHELFYNNGNMFLKYKSGAKC----DNGTADKPNYQLHVM 158

Human  1331 FYCDRGTQ-RPVFLKETSD--CSYLFEWRTQYAC----PPFDLTECSFKDGAGN-SFDLSSLSRY 1387
            |.||.... :|:.:...::  ||:...:||..||    .......|...|...| :|||..||
  Fly   159 FSCDYTLDAQPMHVTPYANEVCSFYISYRTPLACLSIPEGLQSNSCRVGDTKSNGTFDLMPLS-- 221

Human  1388 SDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLG--GSKP----VNLGRVRDGPQW 1446
            ..|:.  |.......::|||||.:. ......||..::.||..  .:.|    :|.|.|:..|..
  Fly   222 DSNYH--TSNRQGAFFVINVCKPVL-YGENSMCPAGSSVCLFDSKATNPKERFINFGNVQTHPVV 283

Human  1447 RDGIIVLKYVDGDLCPDGIRKKSTT-IRFTCSESQVNSRPMFIS-AVEDCEYTFAWPTATACPMK 1509
            ..|.::|::.....|........|: |.|:|.:...|:.|.|.. ..:.|.|.|.:.|..||
  Fly   284 EKGQLLLRHESPTPCAKNSSANYTSVIYFSCDKFIRNAHPEFAGLGADSCTYQFNFATPLAC--- 345

Human  1510 SNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGE-NENCPPGVGACFGQ--TR 1571
             |:...|.... ||..|.||||||.:...|.....|... :::|.. ...|....|||:.|  |.
  Fly   346 -NDLKPCTAFT-STNELLDLSSLSSKPARTLLKDGKNYT-IAVCAHAGAPCQENGGACYEQNSTT 407

Human  1572 ISVGKANKRLRYVDQV--LQLVYKDGSPCPSKSGL-SYKSVISFVCRPEARPTN-------RPML 1626
            ||:|.:|.:||: :|.  |.|:|:||:.|.:.:|: .:.:.|.|||...|...|       ...|
  Fly   408 ISLGNSNSQLRF-NQTGSLYLLYEDGAECSTATGMRRWSTKIEFVCANNATKDNGASTAGGSDSL 471

Human  1627 ISLDKQTCTLFFSWHTPLACEQATECSV------------RNGSSIVDLSPLIHRTGGYEAYDE- 1678
            ..::...|.|...:.|||||.:...|..            .:|..::||:|||..|..|||..|
  Fly   472 KIIEDSNCQLLIQYQTPLACREPIRCKATTYVDHTNDGLGSSGDELIDLTPLISATDNYEARVEL 536

Human  1679 --SEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVC--KVPIDGPPIDIGRVAGPPILN----- 1734
              |.:........|::|:|:||.|.:.:.|..|:|.|  ||...|.| :..|..|.|:::
  Fly   537 PASMEHLVPKTTKFFLNVCRPLVPKYQLGCAGGSAACMAKVTAAGAP-EEERSMGFPLVSLTQRN 600

Human  1735 -PIANEIYLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDE 1798
             ..|...||   ...||..|.....::.|.|:|......|.|.|....:|.:.|||||.|.||..
  Fly   601 RTFAELAYL---KGDPCPTDNTSELSTHILFNCNMRAGRGQPVLRSVEDCAYRFEWETNVFCPPH 662

Human  1799 ---VRMDGCTLTDEQLLYSFNLSSLS-TSTFKVTRD--SRTYSVGVCTFAVGPEQGGCKDGGVCL 1857
               ...|.|.|..::|...||..|.. |...|:..|  :...||.:|    |..:....|....|
  Fly   663 ECTFSADTCDLVHDELGRRFNFKSAPFTKDGKIEIDYNATKMSVNIC----GAHRKAMTDYSQAL 723

Human  1858 LS---GTKGASFGRLQSMKLDYR--HQDEAVVLSYVNGD-RCPPETDDGVPCVFPFIFNGKSYEE 1916
            ::   ..:..:.||..:|.:..|  ..|:....|.::.| :|........|.:..|:..|.:.:.
  Fly   724 VNIFFTHESPNCGREGTMNVQIRLICSDQTESSSTISSDQQCNLLYVQRTPSICEFLSLGATQQN 788

Human  1917 CIIESRAKLWCSTTA 1931
              .||......||::
  Fly   789 --FESNGSTSSSTSS 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IGF2R	NP_000867.3	CIMR	128..265	CDD:425923
		CIMR	423..573	CDD:425923
		CIMR	575..716	CDD:425923
		CIMR	723..875	CDD:425923
		CIMR	1031..1178	CDD:425923
		ATG27	1250..>1365	CDD:476860	30/129 (23%)
		CIMR	1322..1462	CDD:425923	38/161 (24%)
		CIMR	1466..1599	CDD:425923	45/139 (32%)
		CIMR	1608..1731	CDD:425923	43/146 (29%)
		CIMR	1759..1894	CDD:425923	38/146 (26%)
		FN2	1897..1942	CDD:238019	7/35 (20%)
		CIMR	1949..2083	CDD:425923
		CIMR	2089..2233	CDD:425923
		CIMR	2241..>2280	CDD:425923
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2424..2491
Lerp	NP_001262996.1	CIMR	<49..143	CDD:425923	24/103 (23%)
		CIMR	157..298	CDD:425923	36/145 (25%)
		CIMR	307..435	CDD:425923	45/134 (34%)
		CIMR	445..>574	CDD:425923	36/128 (28%)
		CIMR	623..>666	CDD:425923	15/42 (36%)