DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and LRIG2

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_055628.1 Gene:LRIG2 / 9860 HGNCID:20889 Length:1065 Species:Homo sapiens


Alignment Length:743 Identity:179/743 - (24%)
Similarity:275/743 - (37%) Gaps:198/743 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 VLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPN---LEELTLSDNSIINMDPN 221
            :|.|...|.|:...|.:.  .:.:||.....|.         ||:   |..|...|.:|::...|
Human    32 LLLLPAAGAGLCPAPCSC--RIPLLDCSRRKLP---------APSWRALSGLLPPDTAILDFSHN 85

  Fly   222 AFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLD--GDCLGHLQKLRTLRLEG 284
                     |||..|..|:|   |:.|      .:::|.|.|..:.  |:   ....:..|.|..
Human    86 ---------RLSNWNISLES---QTLQ------EVKMNYNELTEIPYFGE---PTSNITLLSLVH 129

  Fly   285 NLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL-TA 348
            |:...|...||.....||:|:|.||:::.|....|||| .|..|.|..|:|..:.||...|| ::
Human   130 NIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSS 193

  Fly   349 LKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELP--RSMQMLDMRANPLSTISPGA 411
            |.|::|:.|.:|.:|..:.||..||.|.:..||::.:......  .|::.|.|:.|.:|.:..||
Human   194 LLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGA 258

  Fly   412 FRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLK 476
            |.|::.:.:|            |||..:...:.|....|::           .|:.|.:..|:::
Human   259 FFGLNNMEEL------------ELEHNNLTRVNKGWLYGLR-----------MLQQLYVSQNAIE 300

  Fly   477 RI-PNL-SSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLD 539
            || |:. ..|:.|..||||.||:.::....|.||..|..|.|..||:..:....|:.:..||.||
Human   301 RISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLD 365

  Fly   540 LEGNEISYI---HKEAFSGFTALEDLNLGNNIFPELPES---GLRALLHLKTFNNPKLREFPPPD 598
            |..||||:.   ..|||:|.|:|..|.|..|....:.:.   ||.:|.||...||          
Human   366 LRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNN---------- 420

  Fly   599 TFPRIQTLILSYAYHCCAFLPLVAMSSQKKT---SQVQEAVLFPSDAEFDMTL-WNNSMMNIWPQ 659
                                  ..||.|:..   :.::|.:|..|....|..| |    :..|..
Human   421 ----------------------AIMSIQENAFSQTHLKELILNTSSLLCDCHLKW----LLQWLV 459

  Fly   660 MHNLSKQLGAS-MHDPW---ETAIN----------FNEEQLQTQTGGQIATSYM----------- 699
            .:|....:..| .|..|   ::.:|          |.:.|::|.....||...|           
Human   460 DNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSS 524

  Fly   700 ---------------------EEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCL----- 738
                                 |.:......:|.|..|.....||:...|::   |..||:     
Human   525 SDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDE---GKYQCIVTNHF 586

  Fly   739 -------------PMPGPFLPCADLFDWWTLRCGVWVVFLLSLLG----------NGTVVFVLLC 780
                         .||.......||    |:|.|.......:..|          :|...|....
Human   587 GSNYSQKAKLTVNEMPSFLKTPMDL----TIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAAR 647

  Fly   781 SRSKMDVPR---FLVCNLAAADFFMGIY 805
            .|....:|.   |.:.|:...|  ||||
Human   648 ERRMHVMPEDDVFFIANVKIED--MGIY 673

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 5/18 (28%)
LRR_RI 180..>383 CDD:238064 61/208 (29%)
leucine-rich repeat 183..204 CDD:275380 4/20 (20%)
LRR_8 203..263 CDD:290566 16/62 (26%)
leucine-rich repeat 205..228 CDD:275380 5/22 (23%)
leucine-rich repeat 229..252 CDD:275380 8/22 (36%)
LRR_8 252..311 CDD:290566 16/60 (27%)
leucine-rich repeat 253..276 CDD:275380 4/24 (17%)
leucine-rich repeat 277..300 CDD:275380 6/22 (27%)
LRR_8 299..359 CDD:290566 24/60 (40%)
leucine-rich repeat 301..324 CDD:275380 11/22 (50%)
leucine-rich repeat 325..348 CDD:275380 9/23 (39%)
LRR_RI 327..567 CDD:238064 76/247 (31%)
leucine-rich repeat 349..371 CDD:275380 8/21 (38%)
LRR_8 370..425 CDD:290566 15/56 (27%)
leucine-rich repeat 372..393 CDD:275380 5/22 (23%)
leucine-rich repeat 394..415 CDD:275380 7/20 (35%)
leucine-rich repeat 418..486 CDD:275380 13/69 (19%)
leucine-rich repeat 441..464 CDD:275378 2/22 (9%)
LRR_8 487..545 CDD:290566 22/57 (39%)
leucine-rich repeat 487..510 CDD:275380 10/22 (45%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
LRR_8 533..589 CDD:290566 24/61 (39%)
leucine-rich repeat 535..558 CDD:275380 13/25 (52%)
leucine-rich repeat 559..580 CDD:275380 6/23 (26%)
7tm_4 764..>892 CDD:304433 12/55 (22%)
7tm_1 770..1017 CDD:278431 12/49 (24%)
LRIG2NP_055628.1 LRR_RI <46..205 CDD:238064 53/191 (28%)
LRR 1 76..97 9/32 (28%)
LRR 2 98..119 5/29 (17%)
leucine-rich repeat 99..121 CDD:275380 5/30 (17%)
LRR_8 120..179 CDD:290566 21/59 (36%)
LRR 3 121..142 6/20 (30%)
leucine-rich repeat 122..145 CDD:275378 6/22 (27%)
LRR 4 145..166 8/20 (40%)
leucine-rich repeat 146..168 CDD:275380 11/22 (50%)
LRR_8 168..251 CDD:290566 26/82 (32%)
LRR 5 168..189 7/20 (35%)
leucine-rich repeat 169..192 CDD:275380 9/22 (41%)
LRR 6 193..214 6/20 (30%)
leucine-rich repeat 194..216 CDD:275380 8/21 (38%)
LRR 7 216..237 5/20 (25%)
leucine-rich repeat 217..240 CDD:275380 5/22 (23%)
LRR_8 240..299 CDD:290566 18/81 (22%)
LRR 8 240..261 8/20 (40%)
leucine-rich repeat 241..264 CDD:275380 8/22 (36%)
LRR 9 264..285 5/32 (16%)
leucine-rich repeat 265..288 CDD:275380 6/45 (13%)
LRR_RI 266..492 CDD:238064 69/284 (24%)
LRR 10 288..309 6/20 (30%)
leucine-rich repeat 289..312 CDD:275380 7/22 (32%)
LRR_8 312..371 CDD:290566 22/58 (38%)
LRR 11 312..333 8/20 (40%)
leucine-rich repeat 313..336 CDD:275380 10/22 (45%)
LRR 12 336..357 6/20 (30%)
leucine-rich repeat 337..360 CDD:275380 6/22 (27%)
LRR_8 359..422 CDD:290566 25/94 (27%)
LRR 13 360..382 10/21 (48%)
leucine-rich repeat 361..385 CDD:275380 12/23 (52%)
LRR 14 387..408 4/20 (20%)
leucine-rich repeat 388..411 CDD:275380 6/22 (27%)
LRR 15 411..432 8/52 (15%)
leucine-rich repeat 412..434 CDD:275380 8/53 (15%)
LRRCT 445..493 CDD:214507 9/51 (18%)
Ig 502..598 CDD:299845 14/98 (14%)
IG 504..598 CDD:214652 13/96 (14%)
I-set 602..692 CDD:254352 18/78 (23%)
Ig_1 619..693 CDD:143240 12/57 (21%)
I-set 696..783 CDD:254352
Ig 714..783 CDD:299845
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..990
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1003..1040
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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