DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and GPR50

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_004215.2	Gene:	GPR50 / 9248	HGNCID:	4506	Length:	617	Species:	Homo sapiens

Alignment Length:	690	Identity:	140/690 - (20%)
Similarity:	249/690 - (36%)	Gaps:	156/690 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   733 GSVQC-LPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLA 796
            |.:.| ||.| .:.|...:|    :.|.:.:..::.|:||..|:..:..::...:.....|.:|:
Human    12 GCIGCKLPQP-EYPPALIIF----MFCAMVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLS 71

  Fly   797 AADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVL-CQLSGFLAVLSSELSVYTLAVITLERNY 860
            .||..:.||...| ::.|.::|       .|.:|.| ||:.||:..||...|::.:..|.:.|..
Human    72 VADMLVAIYPYPL-MLHAMSIG-------GWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYC 128

  Fly   861 AITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMP--LVGVSDYRKFAVCLPFETTTGPASLTYV 923
            .|.|::...:..|::.....:.:.|:.. ::|::|  .:|..:|........|.....|   .:.
Human   129 YICHSLQYERIFSVRNTCIYLVITWIMT-VLAVLPNMYIGTIEYDPRTYTCIFNYLNNP---VFT 189

  Fly   924 ISLMFINGCAFLTLMG-CYLKMYWAIRGSQ--AWNTNDSRIAK-RMALLVFTDFL----CWSPIA 980
            ::::.|:....|.::| ||::::..:..::  |....|:::|: |..|.:|..||    ||.||.
Human   190 VTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPIN 254

  Fly   981 FFSITAIFGLQLISLEQAK--------IFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTL------ 1031
            ..::     |..:|.::..        :...|:...|||.|..:|.::.:.|:::..|:
Human   255 VLTV-----LVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRH 314

  Fly  1032 -----------CKHFEESRVVGGGGPGGRGAVARTKRGDLPP------------PLLPAAAVAHP 1073
                       .:..:|:|.:.......|.......|....|            ||...||..||
Human   315 PIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHP 379

  Fly  1074 PGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCGENRRRRKQRRQPQQRRQRAYTAAAANPYQY 1138
            .                                      |.....:|..|...||..:|:..::.
Human   380 D--------------------------------------RASGHPKPHSRSSSAYRKSASTHHKS 406

  Fly  1139 QFAELRQQRQNRASS-----ISSENFCSSRSSSWRHGPPSSAPVPPGNCSMPLKMLEPHAHPHGH 1198
            .|:      .::|:|     :|..    |:.:|   |.|.||.|.|...|:..|.    ...|..
Human   407 VFS------HSKAASGHLKPVSGH----SKPAS---GHPKSATVYPKPASVHFKA----DSVHFK 454

  Fly  1199 GRRRHSAWLITRKTSQDSNLSSSRNDSSASATTASTSTFRLSRSSAGSSTPLPS------IIAHN 1257
            |...|.      |........:|.|....:....|..:...|..||.:|.|.|:      ..:|.
Human   455 GDSVHF------KPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHA 513

  Fly  1258 GKAQLDAVKPRLVRQEAVQEEEDSSPPRLGVRFLPTIPSAADSSVVMEDGDSANTGVASFLGMPL 1322
            .....|..||...........::   |.|.....|.||:.|..  |.:|.|...:..:...|...
Human   514 EPTTADYPKPATTSHPKPTAADN---PELSASHCPEIPAIAHP--VSDDSDLPESASSPAAGPTK 573

  Fly  1323 PGASS------GFLIAPT--TAATTSPPPVVLQPAKPPPD 1354
            |.||.      ..|..||  |.:|.....||:...:..||
Human   574 PAASQLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPD 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	29/128 (23%)
		7tm_1	770..1017	CDD:278431	58/265 (22%)
GPR50	NP_004215.2	7tm_4	39..>198	CDD:304433	36/170 (21%)
		7tm_1	45..294	CDD:278431	58/265 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..438		25/148 (17%)
		DUF4045	<364..600	CDD:289995	61/301 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..596		30/136 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910