DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and RLP12

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_177296.2	Gene:	RLP12 / 843481	AraportID:	AT1G71400	Length:	847	Species:	Arabidopsis thaliana

Alignment Length:	650	Identity:	152/650 - (23%)
Similarity:	238/650 - (36%)	Gaps:	206/650 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 LTLSDNS--IINMD-PNAF-----------YGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQL 258
            :|.:|.|  :|::| ||.|           :.|..|:.|.|.||.|....|.|...|:.||.:.|
plant    77 VTCNDKSGQVISLDIPNTFLNNYLKTNSSLFKLQYLRHLDLTNCNLYGEIPSSLGNLSHLTLVNL 141

  Fly   259 NGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMP 323
            ..|..|......:|:|.:||.|.|..|:......::|..|..|..|.|.||.|.       .::|
plant   142 YFNKFVGEIPASIGNLNQLRHLILANNVLTGEIPSSLGNLSRLVNLELFSNRLV-------GKIP 199

  Fly   324 NLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDT 388
            :              |.|.||.|..|.:  ..:|||..:|..|..||.|..|.:|.|:|    ..
plant   200 D--------------SIGDLKQLRNLSL--ASNNLIGEIPSSLGNLSNLVHLVLTHNQL----VG 244

  Fly   389 ELPRSM-QMLDMRA-----NPLSTISPGAFRGMSKLRKLILSDVRTLRSFP-ELEACHALE---- 442
            |:|.|: .::::|.     |.||...|.:|..::||...:||......:|| ::...|.||
plant   245 EVPASIGNLIELRVMSFENNSLSGNIPISFANLTKLSIFVLSSNNFTSTFPFDMSIFHNLEYFDV 309

  Fly   443 ---------------ILKLDRAGIQE-------------------------------VPANLCRQ 461
                           |..|:...:||                               :|.::.|.
plant   310 SYNSFSGPFPKSLLLIPSLESIYLQENQFTGPIEFANTSSSTKLQDLILGRNRLHGPIPESISRL 374

  Fly   462 TPRLKSLELKTNSLKRI--PNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKA- 523
            . .|:.|::..|:....  |.:|...:|..||||.|.:|   |:....|.:||.::||:|...:
plant   375 L-NLEELDISHNNFTGAIPPTISKLVNLLHLDLSKNNLE---GEVPACLWRLNTMVLSHNSFSSF 435

  Fly   524 --------------LPQDAFQG-IP-------KLQLLDLEGNEISYIHKEAFSGFT-ALEDLNLG 565
                          |..::||| ||       .|..|||..|..|.........|: ::::||||
plant   436 ENTSQEEALIEELDLNSNSFQGPIPYMICKLSSLGFLDLSNNLFSGSIPSCIRNFSGSIKELNLG 500

  Fly   566 NNIFP-ELPE--SGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQK 627
            :|.|. .||:  |....|:.|...:|....:||        ::||      .|..|.||.:.|.|
plant   501 DNNFSGTLPDIFSKATELVSLDVSHNQLEGKFP--------KSLI------NCKALELVNVESNK 551

  Fly   628 KTSQVQEAVLFPSDAEFDMTLWNNSMMNI------------------------------------ 656
                :::  :|||        |..|:.::
plant   552 ----IKD--IFPS--------WLESLPSLHVLNLRSNKFYGPLYHRHASIGFQSLRIIDISHNNF 602

  Fly   657 -----------WPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSG 710
                       |..|..|::::...|.:.|..|.::..|......|..::...:...|...|.||
plant   603 SGTLPPYYFSNWKDMTTLTEEMDQYMTEFWRYADSYYHEMEMVNKGVDMSFERIRRDFRAIDFSG 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	56/188 (30%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	22/68 (32%)
		leucine-rich repeat	205..228	CDD:275380	9/33 (27%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	14/59 (24%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	78/322 (24%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	18/60 (30%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	6/26 (23%)
		leucine-rich repeat	418..486	CDD:275380	19/120 (16%)
		leucine-rich repeat	441..464	CDD:275378	8/72 (11%)
		LRR_8	487..545	CDD:290566	25/80 (31%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	11/45 (24%)
		LRR_8	533..589	CDD:290566	19/66 (29%)
		leucine-rich repeat	535..558	CDD:275380	7/23 (30%)
		leucine-rich repeat	559..580	CDD:275380	9/23 (39%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
RLP12	NP_177296.2	LRRNT_2	36..80	CDD:285463	1/2 (50%)
		LRR_8	112..170	CDD:290566	21/57 (37%)
		leucine-rich repeat	112..135	CDD:275380	9/22 (41%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		LRR_8	159..218	CDD:290566	20/81 (25%)
		leucine-rich repeat	160..183	CDD:275380	7/22 (32%)
		leucine-rich repeat	184..207	CDD:275380	10/43 (23%)
		LRR_RI	198..479	CDD:238064	73/304 (24%)
		LRR_8	206..266	CDD:290566	20/65 (31%)
		leucine-rich repeat	208..231	CDD:275380	8/24 (33%)
		leucine-rich repeat	232..255	CDD:275380	8/26 (31%)
		leucine-rich repeat	256..279	CDD:275380	6/22 (27%)
		leucine-rich repeat	280..352	CDD:275380	12/71 (17%)
		leucine-rich repeat	304..322	CDD:275380	2/17 (12%)
		LRR_8	351..411	CDD:290566	13/60 (22%)
		leucine-rich repeat	353..376	CDD:275380	2/23 (9%)
		LRR_RI	374..601	CDD:238064	59/258 (23%)
		leucine-rich repeat	377..400	CDD:275380	5/22 (23%)
		leucine-rich repeat	401..422	CDD:275380	9/23 (39%)
		leucine-rich repeat	445..468	CDD:275380	6/22 (27%)
		leucine-rich repeat	469..493	CDD:275380	7/23 (30%)
		leucine-rich repeat	494..517	CDD:275380	9/22 (41%)
		LRR_8	516..576	CDD:290566	18/87 (21%)
		leucine-rich repeat	518..541	CDD:275380	8/36 (22%)
		leucine-rich repeat	542..565	CDD:275380	10/36 (28%)
		leucine-rich repeat	592..616	CDD:275380	1/23 (4%)
		leucine-rich repeat	617..683	CDD:275380	10/50 (20%)
		LRR_8	682..742	CDD:290566
		LRR_4	682..719	CDD:289563
		leucine-rich repeat	684..707	CDD:275380
		leucine-rich repeat	708..729	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000