DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and DRC3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_011522320.1	Gene:	DRC3 / 83450	HGNCID:	25384	Length:	562	Species:	Homo sapiens

Alignment Length:	336	Identity:	79/336 - (23%)
Similarity:	121/336 - (36%)	Gaps:	104/336 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 EILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFN 506
            :||::|         ||. |...|:.|:|..|.:::|..|.:...|..||||.|.||.|:|  .:
Human    74 DILRID---------NLW-QFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEG--LD 126

  Fly   507 GLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEIS------YIHKEAFSGFTALEDLNLG 565
            .|..|.||.|..|||..:  |:...:.|||:|.|..|.|.      |:.:     |..|..|:|.
Human   127 TLVNLEDLSLFNNRISKI--DSLDALVKLQVLSLGNNRIDNMMNIIYLRR-----FKCLRTLSLS 184

  Fly   566 NNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKK-- 628
            .|...|..:                                   |....||:||.:.....::
Human   185 RNPISEAED-----------------------------------YKMFICAYLPDLMYLDYRRID 214

  Fly   629 --TSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTG 691
              |:.|..:|..|.:.:...           ||     |:|..:.|......:...|..:|.|..
Human   215 DHTASVSLSVSQPCETDSSS-----------PQ-----KKLAEAKHQYSIDELKHQENLMQAQLE 263

  Fly   692 GQIATSYMEEYFEEHDVSGPATGYGF-----GTGLFSGMSTEDFQPGSVQCLPMPGPFLP----- 746
            .:.|   ..|..|:|..:       |     |:.||..|..||.:..::..||..|..|.
Human   264 DEQA---QREELEKHKTA-------FVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDK 318

  Fly   747 ----CADLFDW 753
                |.::|::
Human   319 FVIICVNIFEY 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	43/130 (33%)
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380	12/43 (28%)
		leucine-rich repeat	441..464	CDD:275378	6/21 (29%)
		LRR_8	487..545	CDD:290566	25/57 (44%)
		leucine-rich repeat	487..510	CDD:275380	11/22 (50%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	14/61 (23%)
		leucine-rich repeat	535..558	CDD:275380	8/28 (29%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
DRC3	XP_011522320.1	leucine-rich repeat	87..108	CDD:275378	6/20 (30%)
		LRR_9	88..213	CDD:317038	43/168 (26%)
		leucine-rich repeat	109..130	CDD:275378	11/22 (50%)
		leucine-rich repeat	131..152	CDD:275378	8/22 (36%)
		leucine-rich repeat	153..177	CDD:275378	8/28 (29%)
		leucine-rich repeat	178..189	CDD:275378	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910