DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and GHR1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001320016.1	Gene:	GHR1 / 827842	AraportID:	AT4G20940	Length:	1037	Species:	Arabidopsis thaliana

Alignment Length:	579	Identity:	137/579 - (23%)
Similarity:	211/579 - (36%)	Gaps:	158/579 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 LEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGD 269
            |:.|.|:.::    |.:.|..|.||.:||:.|..|..:.|........|..|.|:.|...|....
plant    60 LDNLGLTADA----DFSLFSNLTKLVKLSMSNNSLSGVLPNDLGSFKSLQFLDLSDNLFSSSLPK 120

  Fly   270 CLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQ 334
            .:|....||.|.|.||.|......::.||.:|::|::.||.|:....:...|:.:|:.|.|..|.
plant   121 EIGRSVSLRNLSLSGNNFSGEIPESMGGLISLQSLDMSSNSLSGPLPKSLTRLNDLLYLNLSSNG 185

  Fly   335 IMKISAGALKNLTALKVLELDDNLISSLPEG-LSKLSQLQELSITSNRLRWINDTELP---RSMQ 395
            .........:.:::|:||:|..|.|....:| ...|:....:.|:.|||...:...||   .|::
plant   186 FTGKMPRGFELISSLEVLDLHGNSIDGNLDGEFFLLTNASYVDISGNRLVTTSGKLLPGVSESIK 250

  Fly   396 MLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQ-EVPANLC 459
            .|::..|.|.......|:....|:.|.||........|.....:.||:|||...... .:|.||.
plant   251 HLNLSHNQLEGSLTSGFQLFQNLKVLDLSYNMLSGELPGFNYVYDLEVLKLSNNRFSGSLPNNLL 315

  Fly   460 R-----------------------QTPRLKSLELKTNSLK-RIPNLS-SCRDLRLLDLSSNQIE- 498
            :                       .:..|.:|:|.:|||. .:|.|: .|   .|||||:||.|
plant   316 KGDSLLLTTLDLSGNNLSGPVSSIMSTTLHTLDLSSNSLTGELPLLTGGC---VLLDLSNNQFEG 377

  Fly   499 --------------KIQGKPFNG--------LKQLNDLLLSYNRIK-ALPQDAFQGIPKLQLLDL 540
                          .:....|.|        |.:.|.|.||||::. :||:......|||::||:
plant   378 NLTRWSKWENIEYLDLSQNHFTGSFPDATPQLLRANHLNLSYNKLTGSLPERIPTHYPKLRVLDI 442

  Fly   541 EGNEISYIHKEAFSGFTALEDLNLGN-----NIFPELPESGLR--------------------AL 580
            ..|.:......|......||:::|.|     ||.| ||.||.|                    :|
plant   443 SSNSLEGPIPGALLSMPTLEEIHLQNNGMTGNIGP-LPSSGSRIRLLDLSHNRFDGDLPGVFGSL 506

  Fly   581 LHLKT-------------------------------FNNP------------------------- 589
            .:|:.                               |..|
plant   507 TNLQVLNLAANNLSGSLPSSMNDIVSLSSLDVSQNHFTGPLPSNLSSNIMAFNVSYNDLSGTVPE 571

  Fly   590 KLREFPPPDTFPRIQTLIL------SYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDA 642
            .|:.||||..:|....|:|      |.|...         |..|.|:::.:.|:..|.|
plant   572 NLKNFPPPSFYPGNSKLVLPAGSPGSSASEA---------SKNKSTNKLVKVVIIVSCA 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	49/178 (28%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	17/57 (30%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	15/59 (25%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		LRR_RI	327..567	CDD:238064	74/298 (25%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	14/57 (25%)
		leucine-rich repeat	372..393	CDD:275380	6/23 (26%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	22/93 (24%)
		leucine-rich repeat	441..464	CDD:275378	8/46 (17%)
		LRR_8	487..545	CDD:290566	25/81 (31%)
		leucine-rich repeat	487..510	CDD:275380	11/45 (24%)
		leucine-rich repeat	511..534	CDD:275380	8/23 (35%)
		LRR_8	533..589	CDD:290566	22/111 (20%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	12/45 (27%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
GHR1	NP_001320016.1	PLN00113	2..1036	CDD:215061	137/579 (24%)
		leucine-rich repeat	80..103	CDD:275380	6/22 (27%)
		leucine-rich repeat	104..127	CDD:275380	6/22 (27%)
		leucine-rich repeat	128..151	CDD:275380	9/22 (41%)
		leucine-rich repeat	152..175	CDD:275380	6/22 (27%)
		leucine-rich repeat	176..199	CDD:275380	4/22 (18%)
		leucine-rich repeat	200..223	CDD:275380	8/22 (36%)
		leucine-rich repeat	224..248	CDD:275380	6/23 (26%)
		leucine-rich repeat	249..272	CDD:275380	4/22 (18%)
		leucine-rich repeat	296..314	CDD:275380	6/17 (35%)
		leucine-rich repeat	344..387	CDD:275380	17/45 (38%)
		leucine-rich repeat	388..412	CDD:275380	3/23 (13%)
		leucine-rich repeat	413..436	CDD:275380	8/22 (36%)
		leucine-rich repeat	437..460	CDD:275380	5/22 (23%)
		leucine-rich repeat	461..484	CDD:275380	11/23 (48%)
		leucine-rich repeat	485..508	CDD:275380	1/22 (5%)
		leucine-rich repeat	509..532	CDD:275380	1/22 (5%)
		leucine-rich repeat	533..553	CDD:275380	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000