DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and Lrrn3

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_110483.2 Gene:Lrrn3 / 81514 RGDID:71066 Length:707 Species:Rattus norvegicus


Alignment Length:594 Identity:139/594 - (23%)
Similarity:227/594 - (38%) Gaps:166/594 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 LEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNA 222
            :|.|.:.|..:|:|..|..||.:..:|.|..||:.::|.::.|.. ||..|.||.|:        
  Rat    48 MEALTVDCNDLGLLNFPARLPADTQILLLQTNNIARIEHSTDFPV-NLTGLDLSQNN-------- 103

  Fly   223 FYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLF 287
                            |.|:...:.|.::||.|:.|..|.|..|...||..|..|:.|.:..||.
  Rat   104 ----------------LSSVTNINVQKMSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLL 152

  Fly   288 YRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVL 352
            ..|...|..||..|..|:|.||.|.:||.:.|..:|||.:|:|..|.|::|.....:.|..|:.|
  Rat   153 SAISPGAFVGLHNLLRLHLNSNRLQMINSKWFEALPNLEILMLGDNPILRIKDMNFQPLLKLRSL 217

  Fly   353 ELDDNLISSLP-EGLSKLSQLQELSITSNRLRWINDTELPR--SMQMLDMRANPLSTISPGAFRG 414
            .:....::.:| :.|..|..|:.:|...|||..:....|.:  :::.||:..||::.|..|.|..
  Rat   218 VIAGINLTEVPGDALVGLENLESISFYDNRLNKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSN 282

  Fly   415 MSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIP 479
            |..|::|      .:.:.|||        :.:|...:..:|                        
  Rat   283 MLHLKEL------GINNMPEL--------VSIDSLAVDNLP------------------------ 309

  Fly   480 NLSSCRDLRLLDLSSN-QIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGN 543
                  |||.::.::| ::..|....|..|.:|..|:|:.|.:.||.....:.:|.|:       
  Rat   310 ------DLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLK------- 361

  Fly   544 EISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTF----PRIQ 604
            ||| ||.........:..:|:                      |...:|...|...|    |..|
  Rat   362 EIS-IHSNPIRCDCVIRWINM----------------------NKTNIRFMEPDSLFCVDPPEFQ 403

  Fly   605 TLILSYAY-----HCCAFLPLVAMSSQKKTSQVQEAVLFPS--DAEFD--MTLWNNSMMNIWPQM 660
            ...:...:     ..|  |||:|..|            |||  |.|.|  ::|...:.....|::
  Rat   404 GQNVRQVHFRDMMEIC--LPLIAPES------------FPSILDVEADSYVSLHCRATAEPQPEI 454

  Fly   661 HNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEH-----DVSG--PATGYGFG 718
            :             |           .|.:|.::..:.:.|.|..|     |:.|  |..|    
  Rat   455 Y-------------W-----------ITPSGKRLLPNTLREKFYVHSEGTLDIRGITPKEG---- 491

  Fly   719 TGLFSGMST 727
             ||::.::|
  Rat   492 -GLYTCIAT 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 7/20 (35%)
LRR_RI 180..>383 CDD:238064 60/203 (30%)
leucine-rich repeat 183..204 CDD:275380 6/20 (30%)
LRR_8 203..263 CDD:290566 14/59 (24%)
leucine-rich repeat 205..228 CDD:275380 5/22 (23%)
leucine-rich repeat 229..252 CDD:275380 3/22 (14%)
LRR_8 252..311 CDD:290566 23/58 (40%)
leucine-rich repeat 253..276 CDD:275380 9/22 (41%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR_8 299..359 CDD:290566 20/59 (34%)
leucine-rich repeat 301..324 CDD:275380 9/22 (41%)
leucine-rich repeat 325..348 CDD:275380 7/22 (32%)
LRR_RI 327..567 CDD:238064 53/243 (22%)
leucine-rich repeat 349..371 CDD:275380 5/22 (23%)
LRR_8 370..425 CDD:290566 16/56 (29%)
leucine-rich repeat 372..393 CDD:275380 6/22 (27%)
leucine-rich repeat 394..415 CDD:275380 7/20 (35%)
leucine-rich repeat 418..486 CDD:275380 7/67 (10%)
leucine-rich repeat 441..464 CDD:275378 2/22 (9%)
LRR_8 487..545 CDD:290566 14/58 (24%)
leucine-rich repeat 487..510 CDD:275380 6/23 (26%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
LRR_8 533..589 CDD:290566 9/55 (16%)
leucine-rich repeat 535..558 CDD:275380 6/22 (27%)
leucine-rich repeat 559..580 CDD:275380 1/20 (5%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
Lrrn3NP_110483.2 LRRNT 28..72 CDD:214470 8/23 (35%)
LRR 1 70..91 5/20 (25%)
LRR <72..355 CDD:227223 90/351 (26%)
leucine-rich repeat 72..93 CDD:275380 6/21 (29%)
LRR 2 93..114 8/44 (18%)
leucine-rich repeat 94..117 CDD:275380 8/46 (17%)
LRR 3 117..138 9/20 (45%)
leucine-rich repeat 118..141 CDD:275380 9/22 (41%)
LRR 4 141..162 6/20 (30%)
leucine-rich repeat 142..165 CDD:275380 8/22 (36%)
LRR 5 165..186 9/20 (45%)
leucine-rich repeat 166..189 CDD:275380 9/22 (41%)
LRR 6 189..210 7/20 (35%)
leucine-rich repeat 190..213 CDD:275380 7/22 (32%)
LRR 7 213..234 4/20 (20%)
leucine-rich repeat 214..237 CDD:275380 5/22 (23%)
LRR 8 237..258 6/20 (30%)
leucine-rich repeat 238..261 CDD:275380 6/22 (27%)
LRR 9 261..282 7/20 (35%)
leucine-rich repeat 262..285 CDD:275380 8/22 (36%)
LRR 10 285..304 6/32 (19%)
leucine-rich repeat 286..310 CDD:275380 7/67 (10%)
LRR 11 310..332 6/21 (29%)
leucine-rich repeat 311..333 CDD:275380 5/21 (24%)
LRR 12 335..358 6/22 (27%)
leucine-rich repeat 336..359 CDD:275378 6/22 (27%)
PCC 341..>405 CDD:188093 18/93 (19%)
leucine-rich repeat 360..372 CDD:275378 6/19 (32%)
Ig 440..513 CDD:416386 15/89 (17%)
Ig strand B 440..447 CDD:409353 1/6 (17%)
Ig strand C 453..458 CDD:409353 1/28 (4%)
Ig strand C' 461..464 CDD:409353 1/2 (50%)
Ig strand D 470..474 CDD:409353 1/3 (33%)
Ig strand E 479..483 CDD:409353 0/3 (0%)
Ig strand F 493..500 CDD:409353 2/7 (29%)
Ig strand G 503..513 CDD:409353
fn3 526..593 CDD:394996
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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