DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and LRRTM4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001317299.1	Gene:	LRRTM4 / 80059	HGNCID:	19411	Length:	591	Species:	Homo sapiens

Alignment Length:	617	Identity:	142/617 - (23%)
Similarity:	235/617 - (38%)	Gaps:	143/617 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 ERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELT 209
            :|...|:|.|.|.:    :.|.......:|.|:......|.|..|::.||::|.|.....|..|.
Human    32 QRACPKNCRCDGKI----VYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLY 92

  Fly   210 LSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHL 274
            |..|.|.::|.:||.|:.:||.|.|.:..:..|..::|..:..|.:|.|:.|.|.:|..:....|
Human    93 LDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGL 157

  Fly   275 QKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKIS 339
            :||..|.|..|....:|.......|.|:.|:||.|.|..::...|..:..|..|.|:.||..||:
Human   158 RKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKIN 222

  Fly   340 AGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPL 404
            ......|..|:.:.|..|.|.|:.:||:              ..|       .|:..||:..|.:
Human   223 FAHFPRLFNLRSIYLQWNRIRSISQGLT--------------WTW-------SSLHNLDLSGNDI 266

  Fly   405 STISPGAFRGMSKLRKLILSDVRTLRSFPELEACHA-LEILKLDRAG-IQEVPANLCRQTPRLKS 467
            ..|.||.|:.:..|:||.| |...|.:..: |..:| :.::.:..:| :.|...::|.....||:
Human   267 QGIEPGTFKCLPNLQKLNL-DSNKLTNISQ-ETVNAWISLISITLSGNMWECSRSICPLFYWLKN 329

  Fly   468 LELKTNSLKRIPNLSSCRDLRLLDLSSNQI----EKIQGKPFNGLKQLNDLLLSYNRIKALPQDA 528
              .|.|.                  .|..|    :.|||      ::::|.:.:||..
Human   330 --FKGNK------------------ESTMICAGPKHIQG------EKVSDAVETYNIC------- 361

  Fly   529 FQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLRE 593
                          :|:..::.|.             :::.|:.|:..|  ::...|...|.:.:
Human   362 --------------SEVQVVNTER-------------SHLVPQTPQKPL--IIPRPTIFKPDVTQ 397

  Fly   594 --FPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTL---WNN-- 651
              |..|...|..|.......|...:|..::|.|          ..||.|.|...:.:   |..
Human   398 STFETPSPSPGFQIPGAEQEYEHVSFHKIIAGS----------VALFLSVAMILLVIYVSWKRYP 452

  Fly   652 -SMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYF--------EEHD 707
             ||..:  |.|:|.|:......:        :|.|:         .|.::||:        |..|
Human   453 ASMKQL--QQHSLMKRRRKKARE--------SERQM---------NSPLQEYYVDYKPTNSETMD 498

  Fly   708 VSGPATGYGFGTGLFSGMSTEDFQPGSVQCLP 739
            :|  ..|.|..|...|| |.|...|..::.||
Human   499 IS--VNGSGPCTYTISG-SRECEMPHHMKPLP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/20 (15%)
		LRR_RI	180..>383	CDD:238064	58/202 (29%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	19/59 (32%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	48/245 (20%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	13/54 (24%)
		leucine-rich repeat	372..393	CDD:275380	1/20 (5%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	15/69 (22%)
		leucine-rich repeat	441..464	CDD:275378	3/23 (13%)
		LRR_8	487..545	CDD:290566	8/61 (13%)
		leucine-rich repeat	487..510	CDD:275380	5/26 (19%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	6/55 (11%)
		leucine-rich repeat	535..558	CDD:275380	2/22 (9%)
		leucine-rich repeat	559..580	CDD:275380	3/20 (15%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
LRRTM4	NP_001317299.1	leucine-rich repeat	44..62	CDD:275380	3/21 (14%)
		leucine-rich repeat	65..87	CDD:275380	7/21 (33%)
		LRR_RI	<85..291	CDD:238064	65/227 (29%)
		LRR_8	87..146	CDD:290566	19/58 (33%)
		leucine-rich repeat	88..111	CDD:275380	9/22 (41%)
		leucine-rich repeat	112..135	CDD:275380	6/22 (27%)
		LRR_8	134..194	CDD:290566	19/59 (32%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		leucine-rich repeat	160..183	CDD:275380	5/22 (23%)
		leucine-rich repeat	184..207	CDD:275380	7/22 (32%)
		leucine-rich repeat	208..231	CDD:275380	8/22 (36%)
		LRR_8	231..290	CDD:290566	21/80 (26%)
		leucine-rich repeat	232..255	CDD:275380	8/43 (19%)
		leucine-rich repeat	256..279	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..316	CDD:275378	1/11 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910