DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and cmklrl2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_005165256.1	Gene:	cmklrl2 / 795295	ZFINID:	ZDB-GENE-060526-127	Length:	342	Species:	Danio rerio

Alignment Length:	328	Identity:	80/328 - (24%)
Similarity:	142/328 - (43%)	Gaps:	57/328 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   728 EDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVL-LCSRSKMDVPRFL 791
            :||:.|.            |.|.....|:...| ::|||.::|||.|:::. ...|..::...:|
Zfish    29 DDFRAGH------------CKDALCVITVIVNV-IIFLLGIVGNGAVIWITGFKMRKSVNTTWYL 80

  Fly   792 VCNLAAADFFM--GIYLGILAIV-DAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAV 853
              :||.:||..  .:.|.|..|| |....|.|           :|:.:.|:..|:...|::.|.:
Zfish    81 --SLALSDFIFCSTLPLSISRIVMDTWIFGLF-----------MCKFTSFVMTLNMYSSIFILVI 132

  Fly   854 ITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLV---GVSDYRKFAVCLP----F 911
            |:::|..|:...:....|.::::|..::.:.|..:.:::: |..   .|:|.....:|..    .
Zfish   133 ISVDRCIAVKFPVWAQNRRTVQRASLVVLLVWFVSALLSI-PAAYFRNVADKPHVVICYSHYEHH 196

  Fly   912 ETTTGPASLTYVISLMFING--CAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFL 974
            .:|        ::.:.|..|  ...|.:..||..:...:|.:|.  :..::..|.|.:|:...||
Zfish   197 HST--------IVFIRFTFGFLIPLLMISTCYSILICKLRSNQM--SKSTKPYKIMTILITAFFL 251

  Fly   975 CWSPIAFFSITAIFGLQLISLEQA----KIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHF 1035
            ||.|   |.|..|..|......||    :..:|.:..:||..||||||.|.|.|||.|.:.....
Zfish   252 CWLP---FHIVTIVELSQTKDSQAMYRPQQVSVTLASVNSFLNPFLYAFMAKDFKKKCYSFLSKI 313

  Fly  1036 EES 1038
            |.:
Zfish   314 ESA 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	31/131 (24%)
		7tm_1	770..1017	CDD:278431	60/263 (23%)
cmklrl2	XP_005165256.1	7tm_1	58..295	CDD:278431	60/263 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910