DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and rxfp2a

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001315313.1	Gene:	rxfp2a / 792884	ZFINID:	ZDB-GENE-040426-1225	Length:	754	Species:	Danio rerio

Alignment Length:	832	Identity:	194/832 - (23%)
Similarity:	309/832 - (37%)	Gaps:	233/832 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 QNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLR 299
            ::||..|       |.|.:....:.......|..||  :||             :.|.:......
Zfish    75 EHCGDNS-------GWADIFDRTIKKAEPQDLPNDC--YLQ-------------QYPQSCSCKKT 117

  Fly   300 TLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPE 364
            .:|.:::..:::.|::.       |:..|.||.|:|.                .|||.:
Zfish   118 EVECVDVNLHVVPILSS-------NVTWLSLKNNRIR----------------NLDDYI------ 153

  Fly   365 GLSKLSQLQELSITSNRLRWINDTELPR--SMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVR 427
             .||.:|:|.|.:.:|.:..::.....|  ::|.|.:..|.::.:.||.||.:
Zfish   154 -FSKYTQMQRLFLQNNIIETVSSRAFSRLFTLQRLFLSQNNITYLGPGVFRDL------------ 205

  Fly   428 TLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRL--- 489
                       |.|:.|.||...::.:..:.......|..|.:...||.|:||.|.|:.:.|
Zfish   206 -----------HKLDWLVLDHNPLKHITRDTFIGLRSLTYLSMVNVSLMRLPNSSLCQHMPLLTW 259

  Fly   490 LDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFS 554
            ||.:.|.:|.:.........:|..|....|.||.||::.|..:..|..|||..|.||.:.|..|.
Zfish   260 LDFAENDVELLNYSTLMTCTELTVLTFHDNNIKTLPENTFHSLGSLAELDLSCNRISKLPKNTFK 324

  Fly   555 GFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLP 619
            ....|:.||:.:|           .|||:.|.:.         |...::|:|.|
Zfish   325 SLKYLKKLNISHN-----------PLLHIHTGHF---------DHLVQLQSLSL----------- 358

  Fly   620 LVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEE 684
                          |.:..|           |....::..|.|||
Zfish   359 --------------EGIEIP-----------NITTKMFLPMGNLS-------------------- 378

  Fly   685 QLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQ-----PGSVQCLPMPGPF 744
                           ..||                        :|||     |...:|.|.....
Zfish   379 ---------------HIYF------------------------KDFQYCSYAPHVRKCKPNTDGI 404

  Fly   745 LPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGIL 809
            ....||.....||..|||:..::..||..|:.:....|::.::....:..|..||..||:||..|
Zfish   405 SSVEDLLASLVLRVSVWVMAFITCFGNLFVIGMRSFIRAENNLHAACIKVLCFADCLMGVYLFFL 469

  Fly   810 AIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAI-HLNKRLS 873
            .|.|....||:...|:.|..||.|:..||||:||||:||..|..:|||:...|.... ||  |.:
Zfish   470 GIFDVKFRGEYNRNALIWMDSVECRTIGFLAMLSSEVSVLLLTYLTLEKFLVIVFPFSHL--RPA 532

  Fly   874 LKQAGYIMSVGWVFALIMALMPLVGV----SDYRKFAVCLPF--ETTTGPASLTYVISLMF-ING 931
            ..|...|::..|....::|.:||:..    :.|.:..||.|.  :....|.:..|...:.. :|.
Zfish   533 KLQTVLILAFIWFLGFVIAAVPLLNEDLFGNYYGRNGVCFPLHSDRLEKPTAKGYSTGIFLGLNL 597

  Fly   932 CAFLTLMGCYLKMYWAI--RGSQAWNT-----NDSRIAKRMALLVFTDFLCWSPIAFFSITAIFG 989
            .|||.::..|..|:.:|  .|..|.:.     .|..:|.|...:||:|.|||.|        ||.
Zfish   598 VAFLVIVISYSSMFCSIYKTGINATDVRSRLHKDVAVANRFFFIVFSDALCWIP--------IFL 654

  Fly   990 LQLISLEQAKI-------FTVFVLPLNSCCNPFLYAIMTKQFKKDC-VTLCK 1033
            ::.:||.:.:|       ..:|:||:||..||.||.:.|..|::.. :.||:
Zfish   655 VKTLSLMKVEIPGTINSWVVIFILPINSALNPILYTLTTSFFREQVELLLCR 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	28/147 (19%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	5/27 (19%)
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380	4/16 (25%)
		LRR_8	252..311	CDD:290566	7/58 (12%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	1/22 (5%)
		LRR_8	299..359	CDD:290566	11/59 (19%)
		leucine-rich repeat	301..324	CDD:275380	2/22 (9%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	61/244 (25%)
		leucine-rich repeat	349..371	CDD:275380	5/21 (24%)
		LRR_8	370..425	CDD:290566	12/56 (21%)
		leucine-rich repeat	372..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	14/67 (21%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	18/60 (30%)
		leucine-rich repeat	487..510	CDD:275380	5/25 (20%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	17/55 (31%)
		leucine-rich repeat	535..558	CDD:275380	9/22 (41%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tm_4	764..>892	CDD:304433	42/128 (33%)
		7tm_1	770..1017	CDD:278431	82/268 (31%)
rxfp2a	NP_001315313.1	LDLa	42..77	CDD:238060	0/1 (0%)
		leucine-rich repeat	136..159	CDD:275380	10/45 (22%)
		LRR_8	158..218	CDD:290566	17/82 (21%)
		leucine-rich repeat	160..183	CDD:275380	4/22 (18%)
		leucine-rich repeat	184..207	CDD:275380	7/45 (16%)
		leucine-rich repeat	208..231	CDD:275380	4/22 (18%)
		leucine-rich repeat	232..256	CDD:275380	9/23 (39%)
		LRR_8	255..315	CDD:290566	18/59 (31%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		LRR_8	304..360	CDD:290566	21/100 (21%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
		leucine-rich repeat	329..352	CDD:275380	9/42 (21%)
		leucine-rich repeat	353..371	CDD:275380	6/53 (11%)
		7tm_4	422..>647	CDD:304433	67/226 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910