DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lrrc15

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001074151.1	Gene:	lrrc15 / 791200	ZFINID:	ZDB-GENE-031113-8	Length:	564	Species:	Danio rerio

Alignment Length:	580	Identity:	147/580 - (25%)
Similarity:	239/580 - (41%)	Gaps:	89/580 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 VIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEAN 197
            ||.|...:.::... ..:.|.|    :|.::.|:|..:..:|:.:|..:..|.:.|.::..|:.:
Zfish     7 VIIGMCAMKAVASS-CPESCQC----QVTKIVCQGFSVKEIPLPMPPTINALVISNTSIQSLKPS 66

  Fly   198 SF-FMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGN 261
            .| ..|..|......:::|..::|:.|.....|..|......|.|||...||.|..||:|.|:||
Zfish    67 DFQTFAETLTLFVAKNSNITEVEPHTFDQAFNLNALGFSGTMLTSLPDNLFQNLTALTTLTLSGN 131

  Fly   262 ALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLI 326
            .|..|....|..|..:..|.|..||...:..:|..||..||.|.|..|.:..::...|..:.:|.
Zfish   132 KLEVLPSSLLTPLANVNKLDLSKNLLSSLSEDAFRGLDQLEMLMLQRNSIKQLHSSTFQGLSHLR 196

  Fly   327 VLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGL-SKLSQLQELSITSNRLRWINDTEL 390
            .|.|::||:..|.||...:|..|:||.|.||.|..||..| :|:..|::|.::|||
Zfish   197 SLFLQQNQLTDIPAGLFDDLVNLEVLHLQDNKIEQLPANLFAKVQNLKKLYLSSNR--------- 252

  Fly   391 PRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVP 455
                         ||.:..|.|..:..|..:.|.|.|..|..||...
Zfish   253 -------------LSLLPSGIFLSLPNLTHISLYDNRLSRLMPETFG------------------ 286

  Fly   456 ANLCRQTPRLKSLELKTNSLKRIPN--LSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSY 518
                  |..|:.|.|..|.|..:..  .|:..::|||.:|.|:|:.|....|||||:|.::.|..
Zfish   287 ------TMALQELWLYDNLLTHLEENVFSNLTNIRLLVISRNRIQYISPGAFNGLKELKEVSLHT 345

  Fly   519 NRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHL 583
            ||:..:....|:|:|.|..:.:|.|:|..|..:...|.:.|..|.:.||....||:..|..   |
Zfish   346 NRLTNIEPGIFRGLPNLANISIENNQIKQIPIQLLDGVSRLSLLEMQNNSLQNLPKDFLNT---L 407

  Fly   584 KTFNNPKLREFP---PPDTFP----------RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEA 635
            ....|..|.|.|   ..|..|          :::.|.|.    .|:..|  .::.:.....:::.
Zfish   408 SIVENVILHENPWRCDQDIIPFWGWLSQHSEKVKNLSLV----MCSSPP--PLNGRNVRELIEDD 466

  Fly   636 VLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIA 695
            ::..     :||    :|..:....||..   .:....|.::......::.:.|:||..|
Zfish   467 IMVQ-----EMT----TMTTVDTSSHNTP---ASETKRPPDSNFTTISDEKEDQSGGDAA 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	66/204 (32%)
		leucine-rich repeat	183..204	CDD:275380	5/21 (24%)
		LRR_8	203..263	CDD:290566	19/59 (32%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	22/58 (38%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	21/59 (36%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	69/242 (29%)
		leucine-rich repeat	349..371	CDD:275380	11/22 (50%)
		LRR_8	370..425	CDD:290566	11/54 (20%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	14/69 (20%)
		leucine-rich repeat	441..464	CDD:275378	1/22 (5%)
		LRR_8	487..545	CDD:290566	22/57 (39%)
		leucine-rich repeat	487..510	CDD:275380	11/22 (50%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	15/55 (27%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc15	NP_001074151.1	LRRNT	21..48	CDD:214470	6/30 (20%)
		leucine-rich repeat	53..73	CDD:275380	4/19 (21%)
		LRR_RI	<163..253	CDD:238064	34/111 (31%)
		LRR_8	170..229	CDD:290566	21/58 (36%)
		leucine-rich repeat	171..194	CDD:275380	6/22 (27%)
		leucine-rich repeat	195..218	CDD:275380	9/22 (41%)
		LRR_8	218..277	CDD:290566	23/80 (29%)
		leucine-rich repeat	219..242	CDD:275380	11/22 (50%)
		LRR_4	241..280	CDD:289563	13/60 (22%)
		leucine-rich repeat	243..266	CDD:275380	9/44 (20%)
		leucine-rich repeat	267..289	CDD:275380	8/45 (18%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..372	CDD:290566	22/59 (37%)
		leucine-rich repeat	314..337	CDD:275380	11/22 (50%)
		leucine-rich repeat	338..361	CDD:275380	6/22 (27%)
		leucine-rich repeat	362..385	CDD:275380	6/22 (27%)
		TPKR_C2	418..467	CDD:301599	7/54 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910