DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrrc9

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_006516438.1	Gene:	Lrrc9 / 78257	MGIID:	1925507	Length:	1457	Species:	Mus musculus

Alignment Length:	621	Identity:	152/621 - (24%)
Similarity:	251/621 - (40%)	Gaps:	132/621 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LQHLQQQQQQNPQTVQQLSQITVNRTS------------KSASVTPTGIRENVMLPSAD----PE 105
            |:||.....|..:|.::::.:..:.||            |.|::..:.|.....|...|    .|
Mouse   753 LKHLDLSWNQLKKTGEEINVLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLDGLVISE 817

  Fly   106 KEAQ---------------ILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCT 155
            :|.:               :|...|.:|.....|||..:|       :.|..|.:  |..|.|.|
Mouse   818 EETRAALKFISGTKITQLTLLQHSSSKEERPRMLSTWPSA-------KILTQISK--LGPHFHLT 873

  Fly   156 GS--LEVLRLSCRGIGILAVPVNLP--NEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |:  .::..|:..|..:..: .||.  ..:......||||:|:|  ......|||||||..|.|.
Mouse   874 GNWYSKITALNLDGQHLFEI-TNLEKLENLKWASFSNNNLSKME--GLESCVNLEELTLDGNCIS 935

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .::  ....|.||.|||:.|..|..|...:|..|..|.||.|..|.:.||..     |||..||
Mouse   936 KIE--GITRLTKLSRLSMNNNLLTGLEKHTFDNLLHLHSLSLENNRITSLSA-----LQKTFTL- 992

  Fly   282 LEGNLFYRIPTNALA---------GLRTLEALNLGSNLLTIINDEDFP-----RMPNLIVLLLKR 332
                :...|..|.:|         ||..|..|::..|:: |.|.|::.     .:|.|
Mouse   993 ----IELYISNNYIAVNQEIYNLKGLCNLVILDMYGNII-IWNQENYRFFVIFHLPEL------- 1045

  Fly   333 NQIMKISAGALKNLTALKVL--ELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELP---- 391
            ..:..:|....:..||..:.  .|..::|:. .:|.|...|:|||:.||:.:|.::  .:|
Mouse  1046 KALDGVSIETSETETAKDLFGGRLTSDMIAE-RQGHSNFIQMQELNWTSSAIRTVD--LIPVDHF 1107

  Fly   392 RSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKL---------- 446
            |::..::::.|.|::.|...:....|:..|..:.:.::  .|.|:....|...:|
Mouse  1108 RNVSNVNLQNNNLTSFSGLIYLPNVKVLCLNYNHIESI--MPRLKPQTHLSSRQLLYQKVPSSGY 1170

  Fly   447 ----------DRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPN-----LSSCRDLRLLDLSSNQ 496
                      |..|.:.:|       |.::|||:.......|.|     |:..|:|:.|.|..|:
Mouse  1171 GQQGTSKLNRDSVGSENLP-------PIMQSLEVLHLGYNGICNLVQLQLNRLRNLKFLFLQGNE 1228

  Fly   497 IEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALED 561
            |.:::|  .:.|..|.:|::.:|||:|....||.....|.:|.||.|.:..:.|  ......||.
Mouse  1229 ISQVEG--LDNLIVLQELVVDHNRIRAFNDTAFSKPSSLLMLHLEENRLRELSK--LQSLVKLEK 1289

  Fly   562 LNLGNNIFPELPE----SGLRALLHLKTFNNPKLRE 593
            |.||.|...::.|    ..:.:|..|..:.||..|:
Mouse  1290 LFLGYNKIQDITELEKLDVIPSLRELTVYGNPICRK 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/22 (18%)
		LRR_RI	180..>383	CDD:238064	64/218 (29%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	25/59 (42%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	20/67 (30%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/31 (23%)
		LRR_8	299..359	CDD:290566	12/66 (18%)
		leucine-rich repeat	301..324	CDD:275380	6/27 (22%)
		leucine-rich repeat	325..348	CDD:275380	2/22 (9%)
		LRR_RI	327..567	CDD:238064	62/270 (23%)
		leucine-rich repeat	349..371	CDD:275380	4/23 (17%)
		LRR_8	370..425	CDD:290566	14/58 (24%)
		leucine-rich repeat	372..393	CDD:275380	7/24 (29%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	15/92 (16%)
		leucine-rich repeat	441..464	CDD:275378	5/42 (12%)
		LRR_8	487..545	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	15/59 (25%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	7/24 (29%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc9	XP_006516438.1	internalin_A	<32..>264	CDD:380193
		leucine-rich repeat	47..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380
		leucine-rich repeat	100..121	CDD:275380
		leucine-rich repeat	122..143	CDD:275380
		leucine-rich repeat	144..166	CDD:275380
		leucine-rich repeat	167..191	CDD:275380
		leucine-rich repeat	192..223	CDD:275380
		internalin_A	685..>959	CDD:380193	55/219 (25%)
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380
		leucine-rich repeat	731..752	CDD:275380
		leucine-rich repeat	753..779	CDD:275380	5/25 (20%)
		leucine-rich repeat	780..806	CDD:275380	3/25 (12%)
		leucine-rich repeat	807..865	CDD:275380	13/64 (20%)
		leucine-rich repeat	866..901	CDD:275380	9/35 (26%)
		internalin_A	879..>1262	CDD:380193	106/419 (25%)
		leucine-rich repeat	902..923	CDD:275380	6/22 (27%)
		leucine-rich repeat	924..945	CDD:275380	9/22 (41%)
		leucine-rich repeat	946..969	CDD:275380	9/22 (41%)
		leucine-rich repeat	992..1016	CDD:275380	6/28 (21%)
		leucine-rich repeat	1017..1044	CDD:275380	6/27 (22%)
		leucine-rich repeat	1132..1157	CDD:275380	5/26 (19%)
		leucine-rich repeat	1158..1194	CDD:275380	5/42 (12%)
		leucine-rich repeat	1195..1218	CDD:275380	5/22 (23%)
		leucine-rich repeat	1219..1240	CDD:275380	7/22 (32%)
		LRR_9	<1227..1366	CDD:373143	30/103 (29%)
		leucine-rich repeat	1241..1264	CDD:275380	8/22 (36%)
		leucine-rich repeat	1265..1286	CDD:275380	6/22 (27%)
		leucine-rich repeat	1287..1311	CDD:275380	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910