DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and drc3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_021327254.1	Gene:	drc3 / 777619	ZFINID:	ZDB-GENE-061103-349	Length:	514	Species:	Danio rerio

Alignment Length:	442	Identity:	95/442 - (21%)
Similarity:	165/442 - (37%)	Gaps:	123/442 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 TNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDD 356
            |....|::..|.|.|..:...|:.........:|..|.|..|.|.:|.  .|:|||.|..|:|..
Zfish    26 TRYTEGIQLEEVLELRLDYRNILKIYHLWSFSSLTKLQLDNNAIERIE--GLENLTNLTWLDLSF 88

  Fly   357 NLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKL 421
            |.|..: |||..|.:||:||:.:||:..|.:.:..:.:|:|.:..|.::.
Zfish    89 NKIEVI-EGLQTLVKLQDLSLFNNRISVIENLDTLQRLQVLSLGNNSIAQ--------------- 137

  Fly   422 ILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRD 486
             |.:|..||.|..|..        |:.||           .|..:....||.....:|.|... |
Zfish   138 -LENVIYLRRFQSLRT--------LNLAG-----------NPICEEDRYKTFVSAYLPELVYL-D 181

  Fly   487 LRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKE 551
            .||||..:.:....:              ..| .|:.:.|:..|....::...:...|:. :||:
Zfish   182 YRLLDEQTRETANAK--------------YQY-AIEEMRQNEMQEQQAMEAQKISNEELQ-LHKD 230

  Fly   552 AFSGFTALEDLN---LGNNIFPELPESGLRALLH-----LKTFNNPKLREFPPPDTFPRIQTLIL 608
            ||     :|:||   |.:::|.:.|::...|||.     |:.|.:             |::.:.:
Zfish   231 AF-----VENLNGAQLFHSMFADDPDAEKLALLPGVDALLEEFRS-------------RMEAVCM 277

  Fly   609 SY----------------AYHCCAFLPLVAMSSQK--------------KTS---QVQEAVLFPS 640
            ..                ::..|: ...||.:.||              ||:   |:|:||
Zfish   278 QMFEAGLSQYSRRSAEVESFFSCS-REAVAENKQKAAQIAADFESFRRLKTAEMHQIQDAV---- 337

  Fly   641 DAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGG 692
            ..|..:::....:.:...|:.:|..||...:.|.::..    |..:....||
Zfish   338 QLETHLSVCRQQLTHTSEQLMSLELQLVDQLEDVYKEF----ERNISEMLGG 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	31/90 (34%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	5/18 (28%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380	2/7 (29%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	60/242 (25%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	11/54 (20%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	14/67 (21%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	8/57 (14%)
		leucine-rich repeat	487..510	CDD:275380	4/22 (18%)
		leucine-rich repeat	511..534	CDD:275380	4/22 (18%)
		LRR_8	533..589	CDD:290566	16/63 (25%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	6/23 (26%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
drc3	XP_021327254.1	leucine-rich repeat	39..58	CDD:275380	2/18 (11%)
		leucine-rich repeat	59..80	CDD:275378	9/22 (41%)
		LRR_9	61..198	CDD:317038	47/189 (25%)
		leucine-rich repeat	81..102	CDD:275378	9/21 (43%)
		leucine-rich repeat	103..124	CDD:275378	7/20 (35%)
		leucine-rich repeat	125..149	CDD:275378	8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910