DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrguk

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_006506776.1	Gene:	Lrguk / 74354	MGIID:	1921604	Length:	1341	Species:	Mus musculus

Alignment Length:	1147	Identity:	209/1147 - (18%)
Similarity:	358/1147 - (31%)	Gaps:	433/1147 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 LLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPR 392
            |.|...:::.||  .|.....|:.|.|..|.|..| ..:|.:..|.||:.:.|:|....:.:.|:
Mouse   132 LNLSHCELVDIS--ILCGYVHLQKLNLSGNRIEDL-SCVSCMPYLLELNASQNKLTTFFNFKPPQ 193

  Fly   393 SMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPAN 457
            :::.:|..:|.:|.:.                         :|.|.|.|..|.||...|:|:..
Mouse   194 NLKKVDFSSNLISEMY-------------------------DLSAYHTLTQLILDNNEIEEITG- 232

  Fly   458 LCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIK 522
             ......|..|.|..|.:..|..|.:. .:::|.||:|.||.|.|  ...||.|.:|.||:|:|.
Mouse   233 -LENCISLTHLSLAGNKITTIKGLGTL-PIKVLSLSNNMIETITG--LEELKALQNLDLSHNQIS 293

  Fly   523 ALPQDAFQGIPK---LQLLDLEGNEISYIHK-EAFSGFTALEDLNLGNNIFPELPESG---LRAL 580
            :|     ||:..   |::::||.|:|..:.: |.......|..|||..|.....||..   :..|
Mouse   294 SL-----QGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIYML 353

  Fly   581 LHLKTFNNPKLR---------EFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAV 636
            |.|...:..|::         ::.||.....:|    .:..|        .::|..:..::.::.
Mouse   354 LRLTELDQQKIKVEEKVFAVNKYDPPPEVVAVQ----DHMTH--------VVNSMSQPQRIWDST 406

  Fly   637 LFPSDAEFDMTLWNNSMMNIWPQ-------MHNLSKQL------GA--SMHDPWETAINFNEEQL 686
            |...||.:.|.:...      |.       .|.|.:|.      ||  :...|:     |.|
Mouse   407 LPSLDAPYPMLILTG------PAACGKRELAHRLCRQFSTYFRYGACHTTRPPY-----FGE--- 457

  Fly   687 QTQTGGQIATSYM-EEYFEE---------------HDVSGPATGYGFGTGLFSGMSTED------ 729
                |.::...:: :|.|:|               |:       ||.......|::.:.
Mouse   458 ----GDRVDYHFISQEVFDEMLNMGKFILTFNYGNHN-------YGLNRDTIEGIARDGLASCIH 511

  Fly   730 -------------FQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCS 781
                         |:|..:..:||.      .:.::.:..|.|                   |.|
Mouse   512 MELEGVRSLKYSYFEPRYILVVPMD------KEKYEGYLRRKG-------------------LFS 551

  Fly   782 RSKMDVPRFLVCNLAAADFFMGI---YLGIL-AIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVL 842
            |:::::.      ::..|.::.:   |.|.. |:::|..:.      |.:|.            |
Mouse   552 RAEIEIA------VSRVDLYVKVNQKYPGYFDAVINADDMD------IAYQK------------L 592

  Fly   843 SSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAV 907
            |..:..|.....|..:..|.|.|                                |....:|.|.
Mouse   593 SELIREYLGLTETAAKTLAPTAA--------------------------------GAPSSKKTAS 625

  Fly   908 CLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTD 972
            .:|......|                                         .|:|:..|....|:
Mouse   626 GVPAHLVPSP-----------------------------------------RRLARLQADGQKTE 649

  Fly   973 FLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEE 1037
                   ||..:.                |..|:|.|.  :|.|                   .:
Mouse   650 -------AFLEVQ----------------TQAVVPENQ--DPTL-------------------PQ 670

  Fly  1038 SRVVGGGGPGGRGAVARTKRGDLP------PPLLPAAAVAHPPGCRCLRMLPSEMPNWHKME--Q 1094
            |:.:             |:.|:.|      |..:.::|:..|...:       ::|...|.|  |
Mouse   671 SQEL-------------TEEGEPPEKETNVPQQVSSSALGIPQQAQ-------DLPPKVKEEDGQ 715

  Fly  1095 TPSMWQRLRTFCCGENRRRRKQRRQPQQRRQRAYTAAAANPYQYQFAELRQQRQNRASSISSENF 1159
            ..::..::.|...|.    ..:...|..:..::.|.|:..|         .|:...|.::|
Mouse   716 PANLPPKITTEMDGP----EDEPGPPVPKADQSSTLASQEP---------PQQPAPAPTLS---- 763

  Fly  1160 CSSRSSSWRHGPPSSAPVP-----PGNCSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSNLS 1219
                        |..||.|     |.    |...|.|...|         |..::.:..||....
Mouse   764 ------------PQPAPAPTLSPQPA----PAPTLSPQPAP---------APTLSPQPDQDKESG 803

  Fly  1220 SSR--------NDSSASATTASTSTFRLSRSSAGSSTPLPSIIAH---NGKAQLDAVKPRLVRQE 1273
            .::        ::.:..|..||.|..|:......|:.|.|....|   ...:..:..||....|.
Mouse   804 ETKVAPSNPALSEPAQGADLASLSPQRVQDEGTESANPAPRSSTHTLPEDPSHTEVEKPTGGSQR 868

  Fly  1274 AVQEEEDSSP-PRLGVRFLPTIPSAADSSVVMEDGDSANTGVASFLGMPLPGASSGFLIAPT--- 1334
            .::||...:. .|.|..: |.||...||:          |.|....|..||.:.    :|||
Mouse   869 PLKEETPKAEVMRAGTPY-PEIPPPQDST----------TKVREQPGALLPRSR----LAPTRLP 918

  Fly  1335 ---TAA---TTSPPPVVLQPAK-----------PPPDPNDAP 1359
               |.|   :..|.|.:|.|::           |.|.|...|
Mouse   919 QPQTLAPLQSRRPTPKLLSPSREEALGTSSDQTPNPSPRSFP 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	16/54 (30%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	9/30 (30%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380	5/19 (26%)
		LRR_RI	327..567	CDD:238064	65/242 (27%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	9/54 (17%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	15/67 (22%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	23/60 (38%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	16/62 (26%)
		leucine-rich repeat	535..558	CDD:275380	6/23 (26%)
		leucine-rich repeat	559..580	CDD:275380	7/23 (30%)
		7tm_4	764..>892	CDD:304433	17/131 (13%)
		7tm_1	770..1017	CDD:278431	33/250 (13%)
Lrguk	XP_006506776.1	leucine-rich repeat	131..150	CDD:275380	5/19 (26%)
		internalin_A	<132..>333	CDD:380193	62/238 (26%)
		leucine-rich repeat	151..172	CDD:275380	7/21 (33%)
		leucine-rich repeat	173..194	CDD:275380	6/20 (30%)
		leucine-rich repeat	195..216	CDD:275380	5/45 (11%)
		leucine-rich repeat	217..238	CDD:275380	6/22 (27%)
		leucine-rich repeat	258..281	CDD:275380	9/25 (36%)
		leucine-rich repeat	282..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..328	CDD:275380	6/23 (26%)
		GMPK	416..537	CDD:238026	22/151 (15%)
		PHA03247	<678..1233	CDD:223021	69/347 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910