DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and TSHR

DIOPT Version :10

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_000360.2 Gene:TSHR / 7253 HGNCID:12373 Length:764 Species:Homo sapiens


Alignment Length:776 Identity:248/776 - (31%)
Similarity:363/776 - (46%) Gaps:143/776 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   358 LISSLPEGLSKLS---------QLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFR 413
            |:..||..|..:.         |.::..:|...::.|  ..||.|.|.|.:....|.||...||.
Human    11 LLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRI--PSLPPSTQTLKLIETHLRTIPSHAFS 73

  Fly   414 GMSKLRKLILSDVRTLR-----SFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTN 473
            .:..:.::.:|...||:     ||..|.....:||  .:...:..:..:..::.|.||.|.:...
Human    74 NLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEI--RNTRNLTYIDPDALKELPLLKFLGIFNT 136

  Fly   474 SLKRIPNLSS-----------------------------CRDLRLLDLSSNQIEKIQGKPFNGLK 509
            .||..|:|:.                             |.:...|.|.:|....:||..|||.|
Human   137 GLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTK 201

  Fly   510 QLNDLLLSYNR-IKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELP 573
             |:.:.|:.|: :..:.:|||.|:                    :||.:.|:   :.......||
Human   202 -LDAVYLNKNKYLTVIDKDAFGGV--------------------YSGPSLLD---VSQTSVTALP 242

  Fly   574 ESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLF 638
            ..||..|..|...|...|::.|...:|..:....|||..|||||      .:|||...:.|::  
Human   243 SKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAF------KNQKKIRGILESL-- 299

  Fly   639 PSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAIN----------------------- 680
                     :.|.|.|....|..::: .|.:.:|..:|..:.                       
Human   300 ---------MCNESSMQSLRQRKSVN-ALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYV 354

  Fly   681 FNEEQLQTQTG-GQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPF 744
            |.|||.....| ||...:..||..:..|.....|..|         .:||     :.|.|....|
Human   355 FFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICG---------DSED-----MVCTPKSDEF 405

  Fly   745 LPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGIL 809
            .||.|:..:..||..||.|.||:||||..|:.:||.|..|::|||||:||||.|||.||:||.::
Human   406 NPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLI 470

  Fly   810 AIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSL 874
            |.||..|..|:...||.||....|..:||..|.:||||||||.||||||.||||.|:.|::::.|
Human   471 ASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRL 535

  Fly   875 KQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMG 939
            :.|..||..|||...::||:||||:|.|.|.::|||.:|.| |.:|.|::.::.:|..||:.:..
Human   536 RHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTET-PLALAYIVFVLTLNIVAFVIVCC 599

  Fly   940 CYLKMYWAIRGSQAWN--TNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFT 1002
            ||:|:|..:|..| :|  ..|::||||||:|:||||:|.:||:|::::||....||::..:||..
Human   600 CYVKIYITVRNPQ-YNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILL 663

  Fly  1003 VFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAVARTKRGDLPPP 1063
            |...|||||.|||||||.||.|::|...|...|           |.....|:..||...||
Human   664 VLFYPLNSCANPFLYAIFTKAFQRDVFILLSKF-----------GICKRQAQAYRGQRVPP 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 LRR <157..390 CDD:443914 7/40 (18%)
leucine-rich repeat 158..179 CDD:275380
leucine-rich repeat 183..204 CDD:275380
leucine-rich repeat 205..228 CDD:275380
leucine-rich repeat 229..252 CDD:275380
leucine-rich repeat 253..276 CDD:275380
leucine-rich repeat 277..300 CDD:275380
LRR 292..612 CDD:443914 66/297 (22%)
leucine-rich repeat 301..324 CDD:275380
leucine-rich repeat 325..348 CDD:275380
leucine-rich repeat 349..371 CDD:275380 4/21 (19%)
leucine-rich repeat 372..393 CDD:275380 4/20 (20%)
leucine-rich repeat 394..415 CDD:275380 7/20 (35%)
leucine-rich repeat 418..486 CDD:275380 17/101 (17%)
leucine-rich repeat 441..464 CDD:275378 2/22 (9%)
leucine-rich repeat 487..510 CDD:275380 8/22 (36%)
leucine-rich repeat 511..534 CDD:275380 7/23 (30%)
leucine-rich repeat 535..558 CDD:275380 2/22 (9%)
leucine-rich repeat 559..580 CDD:275380 5/20 (25%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264 137/275 (50%)
TM helix 1 755..781 CDD:320264 14/25 (56%)
TM helix 2 788..813 CDD:320264 16/24 (67%)
TM helix 3 833..863 CDD:320264 20/29 (69%)
TM helix 4 875..897 CDD:320264 9/21 (43%)
TM helix 5 918..947 CDD:320264 9/28 (32%)
TM helix 6 956..986 CDD:320264 16/29 (55%)
TM helix 7 996..1021 CDD:320264 15/24 (63%)
TSHRNP_000360.2 leucine-rich repeat 54..77 CDD:275380 7/22 (32%)
LRR_5 66..221 CDD:463839 34/157 (22%)
leucine-rich repeat 78..102 CDD:275380 6/23 (26%)
leucine-rich repeat 103..127 CDD:275380 2/25 (8%)
leucine-rich repeat 147..179 CDD:275380 1/31 (3%)
leucine-rich repeat 180..201 CDD:275380 8/20 (40%)
leucine-rich repeat 202..229 CDD:275380 9/46 (20%)
7tmA_TSH-R 415..689 CDD:320630 137/275 (50%)
TM helix 1 416..442 CDD:320630 14/25 (56%)
TM helix 2 449..474 CDD:320630 16/24 (67%)
TM helix 3 494..524 CDD:320630 20/29 (69%)
TM helix 4 536..558 CDD:320630 9/21 (43%)
TM helix 5 578..607 CDD:320630 9/28 (32%)
TM helix 6 617..647 CDD:320630 16/29 (55%)
TM helix 7 657..682 CDD:320630 15/24 (63%)
Blue background indicates that the domain is not in the aligned region.

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