DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrrc8e

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_082451.2	Gene:	Lrrc8e / 72267	MGIID:	1919517	Length:	795	Species:	Mus musculus

Alignment Length:	563	Identity:	129/563 - (22%)
Similarity:	209/563 - (37%)	Gaps:	172/563 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DETKENPAPDMQNSQEQEPYVHLQHL--QQQQQQNPQTVQQLSQITVNRTSK---SASVTPTGIR 94
            :||..|..||::|.     :..:.||  |.....:.:....||:::.:|..:   :...||..:|
Mouse   348 EETGMNDIPDVKND-----FAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLR 407

  Fly    95 ENV-------------MLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICER 146
            :.:             |||.. |:...::...::|:                      |.:||:.
Mouse   408 QKLQRNMRGRLELSLCMLPGL-PDTVFELSEVEALR----------------------LEAICDI 449

  Fly   147 WLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLS 211
            ...     .|..:::.|  :.:.:|..|..||                .::..|:...|:.:.:.
Mouse   450 SFP-----PGLSQLVNL--QELSLLHSPARLP----------------FSSQIFLRDRLKVICVK 491

  Fly   212 DNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQK 276
            ...:..: |...:||..|:.|.|:  ||  .||:..:| |.|.||:               .|::
Mouse   492 FEELREV-PLWVFGLRGLEELHLE--GL--FPPEMARG-ATLESLR---------------ELKQ 535

  Fly   277 LRTLRLEGNLFYRIP---TNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKI 338
            |:.|.|..|. .::|   |:....|:.|...|.|:.||.:
Mouse   536 LKVLSLRSNA-GKVPASVTDVAGHLQRLSLHNDGARLLAL------------------------- 574

  Fly   339 SAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANP 403
              .:||.|..|:.|||....:..:|..:..|..||||.:..|.||.|.:
Mouse   575 --NSLKKLAVLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEE---------------- 621

  Fly   404 LSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
                              |||          .:.|..|..|:|....|..||.:: |:...|:.|
Mouse   622 ------------------ILS----------FQHCRKLVTLRLWHNQIAYVPEHV-RKLRSLEQL 657

  Fly   469 ELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQ-LNDLLLSYNRIKALPQDAFQG 531
            .|..|.|:.:| .|..|..|||||||.|.:..:  .|..||.| |..|.||||.:::||.:.| .
Mouse   658 YLSHNKLETLPTQLGQCFGLRLLDLSHNGLRSL--PPELGLLQSLQHLALSYNALESLPDELF-F 719

  Fly   532 IPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPE 574
            ..||:.|.|..|.::.:..:. :...||..|.|..|....|||
Mouse   720 CHKLRTLLLGYNHLTQLSPDV-AALQALSRLELKGNRLETLPE 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	44/205 (21%)
		leucine-rich repeat	183..204	CDD:275380	1/20 (5%)
		LRR_8	203..263	CDD:290566	16/59 (27%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	14/61 (23%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	7/25 (28%)
		LRR_8	299..359	CDD:290566	12/59 (20%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	3/22 (14%)
		LRR_RI	327..567	CDD:238064	66/241 (27%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	10/54 (19%)
		leucine-rich repeat	372..393	CDD:275380	8/20 (40%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	19/68 (28%)
		leucine-rich repeat	441..464	CDD:275378	7/22 (32%)
		LRR_8	487..545	CDD:290566	26/58 (45%)
		leucine-rich repeat	487..510	CDD:275380	11/22 (50%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	13/42 (31%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	7/16 (44%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc8e	NP_082451.2	Pannexin_like	1..330	CDD:372171
		PLN00113	412..>756	CDD:215061	111/487 (23%)
		LRR 1	535..556		6/21 (29%)
		leucine-rich repeat	536..558	CDD:275380	6/22 (27%)
		LRR 2	558..578		6/46 (13%)
		leucine-rich repeat	559..582	CDD:275380	9/49 (18%)
		LRR 3	582..603		5/20 (25%)
		leucine-rich repeat	583..605	CDD:275380	6/21 (29%)
		LRR 4	605..626		11/64 (17%)
		LRR	<606..>771	CDD:227223	61/205 (30%)
		leucine-rich repeat	606..630	CDD:275380	12/67 (18%)
		LRR 5	630..651		7/21 (33%)
		leucine-rich repeat	631..653	CDD:275380	7/22 (32%)
		LRR 6	653..674		7/20 (35%)
		leucine-rich repeat	654..676	CDD:275380	8/21 (38%)
		LRR 7	676..697		10/22 (45%)
		leucine-rich repeat	677..699	CDD:275380	11/23 (48%)
		LRR 8	699..720		9/21 (43%)
		leucine-rich repeat	700..722	CDD:275380	9/22 (41%)
		LRR 9	722..744		5/22 (23%)
		leucine-rich repeat	723..745	CDD:275380	4/22 (18%)
		LRR 10	745..766		8/17 (47%)
		leucine-rich repeat	746..766	CDD:275380	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910