DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Lrrtm2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001102939.1	Gene:	Lrrtm2 / 685472	RGDID:	1593785	Length:	515	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	131/544 - (24%)
Similarity:	217/544 - (39%)	Gaps:	114/544 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|    |.|...|...|..:||.......:.|.|.:|::|.||.:.|.....|..|.|..|.|.
  Rat    38 CRC----EKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQLTWLHLDHNQIS 98

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:..:||.||.|||.|.|.:..:..||..:|..|..|.:|.|:.|.|.||..:....|:||:||.
  Rat    99 TVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLH 163

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |..|....||.......|:||.|:|.:|.|..:....|..:..|..|.|:.||:.||:......|
  Rat   164 LRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRL 228

  Fly   347 TALKVLELDDNLISSLPEGLS-KLSQLQELSITSNRLRWINDT--ELPRSMQMLDMRANPLSTIS 408
            ::|..|.|..|.||:|..|:. ..|.|::|.:|.|.::.|:.|  |...::::|.|..|.|:::.
  Rat   229 SSLHTLFLQWNKISNLTCGMEWTWSTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLD 293

  Fly   409 PGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTN 473
                   ||    |||.:|:|.:                 .|:.   .||...:||:.:|.....
  Rat   294 -------SK----ILSSLRSLTT-----------------VGLS---GNLWECSPRVCALASWLG 327

  Fly   474 SLK-RIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQL 537
            |.: |..:...|          :..:..||:         |:|           ||..|......
  Rat   328 SFQGRWEHSILC----------HSPDHTQGE---------DIL-----------DAVHGFQLCWN 362

  Fly   538 LDLEGNEISYIHKEAFSGFTAL--EDLNLGNNIFPELP-ESGLRALLHLKTFNNPKLREFPPPDT 599
            |......::..:::..:.:|.:  ...::|:.   |:| .:|:.....         ..||.||.
  Rat   363 LSTTVTAMATTYRDPTTEYTKISSSSYHVGDK---EIPTTAGIAVTTE---------EHFPEPDN 415

  Fly   600 FPRIQ-----TLILSYAYHCCAFLPLVA-------MSSQKKTSQVQEAVLFPSDAEFDMTLWNNS 652
            ....|     |:.|.:::....|:..::       :...::.|.:|                |:.
  Rat   416 AIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMIQ----------------NHR 464

  Fly   653 MMNIWPQMH--NLSKQLGASMHDP 674
            .:....::|  |:|.|...|.::|
  Rat   465 QLRSQTRLHMSNMSDQGPYSEYEP 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	70/203 (34%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	22/59 (37%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	22/58 (38%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	20/59 (34%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	53/245 (22%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	16/56 (29%)
		leucine-rich repeat	372..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	14/68 (21%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	8/57 (14%)
		leucine-rich repeat	487..510	CDD:275380	2/22 (9%)
		leucine-rich repeat	511..534	CDD:275380	5/22 (23%)
		LRR_8	533..589	CDD:290566	6/58 (10%)
		leucine-rich repeat	535..558	CDD:275380	1/22 (5%)
		leucine-rich repeat	559..580	CDD:275380	4/23 (17%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrtm2	NP_001102939.1	LRR 1	61..83		7/21 (33%)
		leucine-rich repeat	66..86	CDD:275380	7/19 (37%)
		LRR_RI	73..311	CDD:238064	82/268 (31%)
		LRR 2	84..107		7/22 (32%)
		LRR_8	85..145	CDD:290566	22/59 (37%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		LRR 3	109..131		8/21 (38%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		LRR 4	132..155		8/22 (36%)
		LRR_8	134..193	CDD:290566	22/58 (38%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	156..179		9/22 (41%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		LRR_8	181..241	CDD:290566	20/59 (34%)
		LRR 6	181..203		8/21 (38%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		LRR 7	205..227		7/21 (33%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		LRR 8	229..251		8/21 (38%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR 9	252..275		7/22 (32%)
		LRR_8	253..312	CDD:290566	20/89 (22%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		LRR 10	276..299		8/33 (24%)
		leucine-rich repeat	279..300	CDD:275380	9/31 (29%)
		Involved in DLG4-binding	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910