DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and SSTR5

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001044.1	Gene:	SSTR5 / 6755	HGNCID:	11334	Length:	364	Species:	Homo sapiens

Alignment Length:	333	Identity:	87/333 - (26%)
Similarity:	135/333 - (40%)	Gaps:	47/333 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 VVFLL----SLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRM 822
            |::||    .|.||..|::|:|.......|....:.|||.||....:.|..||..:||:...|.
Human    45 VLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFG- 108

  Fly   823 FAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVF 887
                   .|||:|...|..::...||:.|.|::::|..|:.|.:...:....:.|....:..||.
Human   109 -------PVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVL 166

  Fly   888 ALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAF----LTLMGCYLKMYWAI 948
            :|.|:| ||:..:|.::...|  ..:...|..|...:.:::.....|    |.:..|||.:...:
Human   167 SLCMSL-PLLVFADVQEGGTC--NASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKV 228

  Fly   949 RGS----QAWNTNDSRIAKRMALLVFTDFL-CWSPIAFFSITAIFGLQLISLEQAK----IFTVF 1004
            |.:    ........|...||.|:|...|. ||.|  ||::..:.....:..|.|.    .|.|.
Human   229 RAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLP--FFTVNIVNLAVALPQEPASAGLYFFVVI 291

  Fly  1005 VLPLNSCCNPFLYAIMTKQFKKDC-VTLCKHFEESRVVGGGGPGGRGAVARTKRGD-------LP 1061
            :...|||.||.||..::..|::.. ..||..         .|.|.:.|.|...|.|       ..
Human   292 LSYANSCANPVLYGFLSDNFRQSFQKVLCLR---------KGSGAKDADATEPRPDRIRQQQEAT 347

  Fly  1062 PPLLPAAA 1069
            ||...|||
Human   348 PPAHRAAA 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	36/131 (27%)
		7tm_1	770..1017	CDD:278431	67/259 (26%)
SSTR5	NP_001044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		7tm_4	54..319	CDD:304433	71/277 (26%)
		7tm_1	57..304	CDD:278431	67/259 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..364		9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910