DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Aspn

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001165952.1	Gene:	Aspn / 66695	MGIID:	1913945	Length:	373	Species:	Mus musculus

Alignment Length:	451	Identity:	95/451 - (21%)
Similarity:	155/451 - (34%)	Gaps:	174/451 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|...:    :.|..:|:.:||.|:|.:..::||.||.:.:::.|.|....:|..|.|::|.:.
Mouse    72 CQCYSRV----VHCSDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLT 132

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:.|..|....||:||.|.:              .||:.:.||
Mouse   133 KIHPKTFLTTKKLRRLYLSH--------------NQLSEIPLN---------------------- 161

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
                    :| .:||.||              |:|                |::.||.....|.:
Mouse   162 --------LP-KSLAELR--------------IHD----------------NKVKKIQKDTFKGM 187

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLST--ISP 409
            .||.|||                                             |.||||..  |.|
Mouse   188 NALHVLE---------------------------------------------MSANPLENNGIEP 207

  Fly   410 GAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNS 474
            |||.|::...                        :::..|.:..:|..|   .|.|..|.|..|.
Mouse   208 GAFEGVTVFH------------------------IRIAEAKLTSIPKGL---PPTLLELHLDFNK 245

  Fly   475 LK--RIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQL 537
            :.  .:.:|...|:|:.|.|.:|:|..|:...|..:.::.::.|.:|::|.:| ...|.:..||:
Mouse   246 ISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLKKIP-SGLQELKYLQI 309

  Fly   538 LDLEGNEISYIHKEAFSGFTALEDLNLGNNIF-PELPESGLRALLHLKTFNNP-KLREFPP 596
            :.|..|.|:                .:|.|.| |.:|:........:..|||| |..|..|
Mouse   310 IFLHYNSIA----------------KVGVNDFCPTVPKMKKSLYSAISLFNNPMKYWEIQP 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	37/202 (18%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	15/59 (25%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		LRR_8	252..311	CDD:290566	9/58 (16%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR_8	299..359	CDD:290566	12/59 (20%)
		leucine-rich repeat	301..324	CDD:275380	2/22 (9%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		LRR_RI	327..567	CDD:238064	48/243 (20%)
		leucine-rich repeat	349..371	CDD:275380	4/21 (19%)
		LRR_8	370..425	CDD:290566	11/56 (20%)
		leucine-rich repeat	372..393	CDD:275380	0/20 (0%)
		leucine-rich repeat	394..415	CDD:275380	10/22 (45%)
		leucine-rich repeat	418..486	CDD:275380	9/69 (13%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	16/57 (28%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	5/22 (23%)
		LRR_8	533..589	CDD:290566	12/56 (21%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	5/21 (24%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Aspn	NP_001165952.1	LRRNT	68..97	CDD:214470	8/28 (29%)
		leucine-rich repeat	77..96	CDD:275380	6/22 (27%)
		LRR 1	96..117		6/20 (30%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		LRR_8	98..155	CDD:290566	17/70 (24%)
		LRR 2	120..141		6/20 (30%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_RI	<139..333	CDD:238064	69/357 (19%)
		LRR 3	144..166		10/66 (15%)
		leucine-rich repeat	145..165	CDD:275380	9/64 (14%)
		Interaction with TGFB1	159..205		23/151 (15%)
		leucine-rich repeat	166..189	CDD:275380	10/52 (19%)
		LRR 5	189..212		15/67 (22%)
		leucine-rich repeat	190..215	CDD:275380	15/69 (22%)
		LRR_8	234..294	CDD:290566	16/59 (27%)
		LRR 6	235..255		4/19 (21%)
		leucine-rich repeat	236..259	CDD:275380	5/22 (23%)
		LRR 7	259..280		7/20 (35%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		LRR 8	283..305		5/22 (23%)
		LRR 9	306..327		8/36 (22%)
		leucine-rich repeat	307..331	CDD:275380	9/39 (23%)
		LRR 10	328..349		5/20 (25%)
		leucine-rich repeat	332..359	CDD:275380	7/23 (30%)
		LRR 11	350..373		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910