DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and NYX

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001365406.2	Gene:	NYX / 60506	HGNCID:	8082	Length:	476	Species:	Homo sapiens

Alignment Length:	307	Identity:	92/307 - (29%)
Similarity:	141/307 - (45%)	Gaps:	23/307 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LHSI------------CERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLT 192
            ||::            |.|.....|.|:.......:.|...|:|.||..||.|.|.:||..|.|.
Human     6 LHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLR 70

  Fly   193 KLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCG-LKSLPPQSFQGLAQLTSL 256
            .|...:|...|:|..|:|..|::..:.|.||.||.:|..|.|.:.| |:.|..::|..|::|..|
Human    71 FLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRL 135

  Fly   257 QLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPR 321
            .|....|.|:....|..|..||.|....|||.|:| .||.||..|...:|....:..:.......
Human   136 DLAACRLFSVPERLLAELPALRELAAFDNLFRRVP-GALRGLANLTHAHLERGRIEAVASSSLQG 199

  Fly   322 MPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRL--- 382
            :..|..|.|:.|::..:.|||..:...|:.|.|:|||::.|| :....|.:|:.|::..|.|
Human   200 LRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRV 264

  Fly   383 --RWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVR 427
              .|..|.   ..:::|.:..|.::.:..|||:.:|.|..|.|:..|
Human   265 ARAWFADL---AELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNR 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	67/209 (32%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	21/60 (35%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	8/23 (35%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	12/22 (55%)
		LRR_8	299..359	CDD:290566	14/59 (24%)
		leucine-rich repeat	301..324	CDD:275380	2/22 (9%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	31/107 (29%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		LRR_8	370..425	CDD:290566	15/59 (25%)
		leucine-rich repeat	372..393	CDD:275380	6/25 (24%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	4/10 (40%)
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
NYX	NP_001365406.2	LRR_8	61..115	CDD:404697	19/53 (36%)
		leucine-rich repeat	63..82	CDD:275380	6/18 (33%)
		leucine-rich repeat	83..106	CDD:275380	9/22 (41%)
		leucine-rich repeat	107..131	CDD:275380	8/23 (35%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		PPP1R42	150..310	CDD:411060	48/163 (29%)
		leucine-rich repeat	156..178	CDD:275380	12/22 (55%)
		leucine-rich repeat	179..202	CDD:275380	2/22 (9%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		LRR_8	227..285	CDD:404697	17/60 (28%)
		leucine-rich repeat	227..250	CDD:275380	9/22 (41%)
		leucine-rich repeat	251..274	CDD:275380	6/25 (24%)
		leucine-rich repeat	275..296	CDD:275380	5/20 (25%)
		leucine-rich repeat	323..335	CDD:275378
		LRRCT	331..>365	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910