DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and OPN1LW

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_064445.2	Gene:	OPN1LW / 5956	HGNCID:	9936	Length:	364	Species:	Homo sapiens

Alignment Length:	316	Identity:	78/316 - (24%)
Similarity:	138/316 - (43%)	Gaps:	46/316 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   739 PMPGPFLPCADLFDWWTLRCGVWVVFLL--SLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFF 801
            |..||....|.  .|......||::|::  |:..||.|:...:..:.......:::.|||.||..
Human    39 PFEGPNYHIAP--RWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLA 101

  Fly   802 MGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAI 866
            ..:....::||:..: |.| :...|     :|.|.|:...|.....:::||:|:.||...:....
Human   102 ETVIASTISIVNQVS-GYF-VLGHP-----MCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPF 159

  Fly   867 HLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAV---CLP--FETTTGPASLTYVISL 926
            . |.|...|.|...::..|::|.:....|:.|.|.|....:   |.|  |..::.|...:|:|.|
Human   160 G-NVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVL 223

  Fly   927 MFINGCAFLTL---MGCYLKMYWAIRG-------SQAWNTNDSRIAKRMALLVFTDFLCWSPIAF 981
            |..  |..:.|   |.|||:::.|||.       |::....:..:.:.:.:::|...:||.|..|
Human   224 MVT--CCIIPLAIIMLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTF 286

  Fly   982 FSITA------IFGLQLISLEQ--AKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCV 1029
            |:..|      .|...:.:|..  ||..|::        ||.:|..|.:|| ::|:
Human   287 FACFAAANPGYAFHPLMAALPAYFAKSATIY--------NPVIYVFMNRQF-RNCI 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	30/129 (23%)
		7tm_1	770..1017	CDD:278431	64/269 (24%)
OPN1LW	NP_064445.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		7tm_4	68..>264	CDD:304433	50/205 (24%)
		7tm_1	71..322	CDD:278431	64/268 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910