DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and LGR6

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001017403.1	Gene:	LGR6 / 59352	HGNCID:	19719	Length:	967	Species:	Homo sapiens

Alignment Length:	979	Identity:	298/979 - (30%)
Similarity:	454/979 - (46%)	Gaps:	141/979 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |||.....:|...|..:|:.|||.:|......|||..||||:|:...|.....||||.||.|.:.
Human    39 CHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS 103

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSL------DGDCLGHLQ 275
            ::...||.||..||.|.|||..|..:|.::...|..|.||:|:.| |:||      :|     |.
Human   104 HIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDAN-LISLVPERSFEG-----LS 162

  Fly   276 KLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISA 340
            .||.|.|:.|....||..||..|..|:|:.|..|.::.|.|..|..:.:|:||.|..|:|..:..
Human   163 SLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT 227

  Fly   341 GALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRS--MQMLDMRANP 403
            .:.:.|..|:.|:|:.|.:...|..:..|.:||||...:|.::.|.:.....:  :|.:....||
Human   228 HSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 292

  Fly   404 LSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
            :..:...||:.:.||..|.|:....::.||:|:...:||||.|.||||:.:|:.:|:|.|||:.|
Human   293 IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVL 357

  Fly   469 ELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIP 533
            ||..|.::.:|:|..|                        ::|.::.|.:|||..:..|.|..:.
Human   358 ELSHNQIEELPSLHRC------------------------QKLEEIGLQHNRIWEIGADTFSQLS 398

  Fly   534 KLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPD 598
            .||.|||..|.|..||.||||...:|..|:|.:|....||.:||..|:|||...|..|.:....|
Human   399 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKD 463

  Fly   599 TFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNL 663
            :||:::.|.:.|||.||   |....:|..|.|
Human   464 SFPKLRILEVPYAYQCC---PYGMCASFFKAS--------------------------------- 492

  Fly   664 SKQLGASMHDPWETA-INFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMST 727
                     ..||.. ::.::|:...:..|.:|......|.::.|.              ..:..
Human   493 ---------GQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDE--------------LQLEM 534

  Fly   728 EDFQP-GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVP--R 789
            ||.:| .||||.|.||||.||..||:.|.:|..||.:.|||:|.||.|:..:... ..:.:|  :
Human   535 EDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAG-GPVPLPPVK 598

  Fly   790 FLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSV--YTLA 852
            |:|..:|.|:...||..|:||.|||.|.|:|..:...|:..:.|:.:||||||.||.||  .|||
Human   599 FVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLA 663

  Fly   853 VITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTG- 916
            .:....:.:...|...:..|...:||.:..:  ..|.:.|.:||..|.:|....:|||:....|
Human   664 AVQCSVSVSCVRAYGKSPSLGSVRAGVLGCL--ALAGLAAALPLASVGEYGASPLCLPYAPPEGQ 726

  Fly   917 PASLTYVISLMFINGCAFLTLMGCYLKMYWAI-RG--SQAWNTNDSRIAKRMALLVFTDFLCWSP 978
            ||:|.:.::|:.:|...||.:.|.|:|:|..: ||  ...|   |..:.:.:|.|:|.|.|.:.|
Human   727 PAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW---DCAMVRHVAWLIFADGLLYCP 788

  Fly   979 IAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGG 1043
            :||.|..::.||..::.|..|...:.||||.:|.||.||.:....|:.|...|...      .|.
Human   789 VAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPR------AGD 847

  Fly  1044 GGPGGRGAVARTKRG--------------DLPPPLLPAAAVAHPPGCR-----CLRMLPSEMPNW 1089
            .||....|....::.              ||   :|.|:....|||..     .:.::..:.|..
Human   848 SGPLAYAAAGELEKSSCDSTQALVAFSDVDL---ILEASEAGRPPGLETYGFPSVTLISCQQPGA 909

  Fly  1090 HKME 1093
            .::|
Human   910 PRLE 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	74/208 (36%)
		leucine-rich repeat	183..204	CDD:275380	9/20 (45%)
		LRR_8	203..263	CDD:290566	25/59 (42%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	24/64 (38%)
		leucine-rich repeat	253..276	CDD:275380	10/28 (36%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	75/241 (31%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	15/56 (27%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	28/67 (42%)
		leucine-rich repeat	441..464	CDD:275378	12/22 (55%)
		LRR_8	487..545	CDD:290566	13/57 (23%)
		leucine-rich repeat	487..510	CDD:275380	0/22 (0%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	25/55 (45%)
		leucine-rich repeat	535..558	CDD:275380	13/22 (59%)
		leucine-rich repeat	559..580	CDD:275380	8/20 (40%)
		7tm_4	764..>892	CDD:304433	43/131 (33%)
		7tm_1	770..1017	CDD:278431	83/254 (33%)
LGR6	NP_001017403.1	LRRNT	34..68	CDD:214470	10/28 (36%)
		LRR_RI	<57..199	CDD:238064	57/147 (39%)
		leucine-rich repeat	70..91	CDD:275380	9/20 (45%)
		LRR 1	91..112		9/20 (45%)
		LRR_8	92..150	CDD:290566	25/58 (43%)
		leucine-rich repeat	92..115	CDD:275380	11/22 (50%)
		LRR 2	115..136		8/20 (40%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		LRR_RI	131..392	CDD:238064	86/290 (30%)
		LRR 3	139..160		8/21 (38%)
		leucine-rich repeat	140..163	CDD:275380	10/28 (36%)
		LRR 4	163..186		9/22 (41%)
		leucine-rich repeat	164..187	CDD:275380	10/22 (45%)
		LRR_8	186..246	CDD:290566	18/59 (31%)
		LRR 5	187..208		7/20 (35%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		LRR 6	211..232		6/20 (30%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		LRR 7	235..256		5/20 (25%)
		leucine-rich repeat	236..258	CDD:275380	6/21 (29%)
		LRR_8	258..314	CDD:290566	15/55 (27%)
		LRR 8	258..279		6/20 (30%)
		leucine-rich repeat	259..282	CDD:275380	6/22 (27%)
		LRR 9	282..303		5/20 (25%)
		leucine-rich repeat	283..304	CDD:275380	5/20 (25%)
		LRR 10	306..328		7/21 (33%)
		LRR 11	329..350		11/20 (55%)
		leucine-rich repeat	330..344	CDD:275378	9/13 (69%)
		LRR 12	353..374		9/44 (20%)
		leucine-rich repeat	354..399	CDD:275380	15/68 (22%)
		LRR_8	375..434	CDD:290566	24/58 (41%)
		LRR 13	375..396		7/20 (35%)
		leucine-rich repeat	376..390	CDD:275378	5/13 (38%)
		LRR 14	399..420		12/20 (60%)
		leucine-rich repeat	400..423	CDD:275380	13/22 (59%)
		LRR 15	423..443		7/19 (37%)
		leucine-rich repeat	424..444	CDD:275380	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10755
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2595
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41437
orthoMCL	1	0.900	-	-		OOG6_106088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730