DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and RXFP1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001240656.1	Gene:	RXFP1 / 59350	HGNCID:	19718	Length:	784	Species:	Homo sapiens

Alignment Length:	902	Identity:	200/902 - (22%)
Similarity:	314/902 - (34%)	Gaps:	313/902 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 WLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLS 211
            :|..|||     ..|.|....: :.:|||....:.:.||....||..:.:    ::.|:..::|.
Human   107 FLVPHCH-----HALPLPLDSV-VGSVPVQCLCQGLELDCDETNLRAVPS----VSSNVTAMSLQ 161

  Fly   212 DNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQK 276
            .|.|..:.|:.|.....|::|.|||..:.|:...:|:||..||.|.|:.|.:..|.......|.:
Human   162 WNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHR 226

  Fly   277 LRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDF-PRMPNLIVLLLKRNQIMKISA 340
            |..|.:|.|...||......||.:|..|.|.:|:||.:.|:.. ..||.|..|.|:.|.|..
Human   227 LEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHN--- 288

  Fly   341 GALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLS 405
              |:|||.:                  ..|.|..|.:..|::..:|:                 :
Human   289 --LRNLTFI------------------SCSNLTVLVMRKNKINHLNE-----------------N 316

  Fly   406 TISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLEL 470
            |.:|                                 :.|||.
Human   317 TFAP---------------------------------LQKLDE---------------------- 326

  Fly   471 KTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKL 535
                               |||.||:||.:....|..||:|:.|.||||.|:.:..:.|..:.||
Human   327 -------------------LDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKL 372

  Fly   536 QLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTF 600
            :.|.|||.|||.|.:..|                        |.|::|......|
Human   373 KSLSLEGIEISNIQQRMF------------------------RPLMNLSHIYFKK---------- 403

  Fly   601 PRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSK 665
                       :..|.:.|.| .|.:..|..:                  :|:.|
Human   404 -----------FQYCGYAPHV-RSCKPNTDGI------------------SSLEN---------- 428

  Fly   666 QLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDF 730
                                        :..|.::..|
Human   429 ----------------------------LLASIIQRVF--------------------------- 438

  Fly   731 QPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNL 795
                                         ||||..::..||..|:.:....||:..:....:.:|
Human   439 -----------------------------VWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISL 474

  Fly   796 AAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNY 860
            ..||..|||||.::...|....||:...|..|..|..|||.|.||:||:|:||..|..:|||:..
Human   475 CCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYI 539

  Fly   861 AITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKF----AVCLPF--ETTTGPAS 919
            .|.:.....:....:....::.: |:...|:|.:||.....::.:    .||.|.  |.|....:
Human   540 CIVYPFRCVRPGKCRTITVLILI-WITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGA 603

  Fly   920 LTYVISLMF-INGCAFLTLMGCYLKMYWAIRGSQAWNT-------NDSRIAKRMALLVFTDFLCW 976
            ..|.:::.. ||..||:.::..|..|::::..|....|       .:..:|||...:||||.|||
Human   604 QIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCW 668

  Fly   977 SPIAFFSITAIFGLQLISLEQAKI-------FTVFVLPLNSCCNPFLYAIMTKQFKK 1026
            .|        ||.::.:||.|.:|       ..:|:||:||..||.||.:.|:.||:
Human   669 IP--------IFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKE 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	56/203 (28%)
		leucine-rich repeat	183..204	CDD:275380	4/20 (20%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	18/60 (30%)
		leucine-rich repeat	301..324	CDD:275380	8/23 (35%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	47/239 (20%)
		leucine-rich repeat	349..371	CDD:275380	0/21 (0%)
		LRR_8	370..425	CDD:290566	7/54 (13%)
		leucine-rich repeat	372..393	CDD:275380	4/20 (20%)
		leucine-rich repeat	394..415	CDD:275380	2/20 (10%)
		leucine-rich repeat	418..486	CDD:275380	3/67 (4%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	24/57 (42%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	14/55 (25%)
		leucine-rich repeat	535..558	CDD:275380	10/22 (45%)
		leucine-rich repeat	559..580	CDD:275380	1/20 (5%)
		7tm_4	764..>892	CDD:304433	37/127 (29%)
		7tm_1	770..1017	CDD:278431	78/267 (29%)
RXFP1	NP_001240656.1	LDLa	27..62	CDD:238060
		leucine-rich repeat	155..178	CDD:275380	5/22 (23%)
		LRR_8	179..237	CDD:290566	20/57 (35%)
		leucine-rich repeat	179..202	CDD:275380	9/22 (41%)
		LRR_RI	<196..358	CDD:238064	62/275 (23%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		LRR_8	226..286	CDD:290566	21/59 (36%)
		leucine-rich repeat	227..250	CDD:275380	8/22 (36%)
		leucine-rich repeat	251..275	CDD:275380	8/23 (35%)
		LRR_8	274..334	CDD:290566	25/173 (14%)
		leucine-rich repeat	276..299	CDD:275380	9/45 (20%)
		leucine-rich repeat	300..323	CDD:275380	6/72 (8%)
		LRR_8	323..379	CDD:290566	25/96 (26%)
		leucine-rich repeat	324..347	CDD:275380	11/63 (17%)
		leucine-rich repeat	348..371	CDD:275380	8/22 (36%)
		leucine-rich repeat	372..393	CDD:275380	11/44 (25%)
		7tm_1	451..708	CDD:278431	76/265 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810