DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Erbin

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001005868.1	Gene:	Erbin / 59079	MGIID:	1890169	Length:	1450	Species:	Mus musculus

Alignment Length:	484	Identity:	116/484 - (23%)
Similarity:	197/484 - (40%)	Gaps:	100/484 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALA 296
            |...:|.|:.:|.:.|.....|..|.|:.|.:..|... |.:.|.|..|.|..|....:|. ::|
Mouse    27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQ-LFNCQSLHKLSLPDNDLTTLPA-SIA 89

  Fly   297 GLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISS 361
            .|..|..|::..|.:     ::||.                    .:||...|.::|...|.||.
Mouse    90 NLINLRELDVSKNGI-----QEFPE--------------------NIKNCKVLTIVEASVNPISK 129

  Fly   362 LPEGLSKLSQLQELSITSNRLRWINDTELP---------RSMQMLDMRANPLSTISPGAFRGMSK 417
            ||:|.|:|..|.:|        ::||..|.         ..:|:|::|.|.|..:.    :.|::
Mouse   130 LPDGFSQLLNLTQL--------YLNDAFLEFLPANFGRLTKLQILELRENQLKMLP----KTMNR 182

  Fly   418 LRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPN-L 481
            |.:                    ||.|.|......||| .:..|...|:...:..|.|..||. :
Mouse   183 LTQ--------------------LERLDLGSNEFTEVP-EVLEQLSGLREFWMDGNRLTFIPGFI 226

  Fly   482 SSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEIS 546
            .|.|.|..||:|.|.||.:: :..:..:.|.|.|||.|.::.|| :....:..:..|.::.|::.
Mouse   227 GSLRQLTYLDVSKNNIEMVE-EGISTCENLQDFLLSSNSLQQLP-ETIGSLKNVTTLKIDENQLM 289

  Fly   547 YIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTF--NNPKLREFPPP-DTFPRIQTLIL 608
            |: .::..|..::|:|:...|....|| |.:..|.:::||  ::..|::.||. ..:..|..|.|
Mouse   290 YL-PDSIGGLRSIEELDCSFNEIEALP-SSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFL 352

  Fly   609 SYAYHC--CAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGAS- 670
                ||  ...|| ..|...:|...:              .|.:|.:.|: |......:||.|.
Mouse   353 ----HCNKLETLP-EEMGDMQKLKVI--------------NLSDNRLKNL-PFSFTKLQQLTAMW 397

  Fly   671 MHDPWETAINFNEEQLQTQTGGQIATSYM 699
            :.|.....:...:::..|:|...:.|:||
Mouse   398 LSDNQSKPLIPLQKETDTETQKMVLTNYM 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	38/150 (25%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	9/30 (30%)
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380	5/19 (26%)
		LRR_8	252..311	CDD:290566	17/58 (29%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	10/59 (17%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	2/22 (9%)
		LRR_RI	327..567	CDD:238064	60/249 (24%)
		leucine-rich repeat	349..371	CDD:275380	10/21 (48%)
		LRR_8	370..425	CDD:290566	12/63 (19%)
		leucine-rich repeat	372..393	CDD:275380	5/29 (17%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	15/68 (22%)
		leucine-rich repeat	441..464	CDD:275378	8/22 (36%)
		LRR_8	487..545	CDD:290566	17/57 (30%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	13/57 (23%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Erbin	NP_001005868.1	leucine-rich repeat	24..47	CDD:275380	5/19 (26%)
		LRR_RI	<48..209	CDD:238064	51/220 (23%)
		leucine-rich repeat	48..70	CDD:275380	6/22 (27%)
		LRR	70..418	CDD:227223	100/430 (23%)
		leucine-rich repeat	71..93	CDD:275380	7/22 (32%)
		leucine-rich repeat	94..116	CDD:275380	7/46 (15%)
		leucine-rich repeat	117..139	CDD:275380	10/21 (48%)
		LRR_RI	<130..314	CDD:238064	54/219 (25%)
		leucine-rich repeat	140..162	CDD:275380	5/29 (17%)
		leucine-rich repeat	163..185	CDD:275380	7/25 (28%)
		leucine-rich repeat	186..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..231	CDD:275380	6/21 (29%)
		leucine-rich repeat	278..300	CDD:275380	4/22 (18%)
		leucine-rich repeat	301..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	347..369	CDD:275380	8/26 (31%)
		LRR_4	368..411	CDD:289563	9/57 (16%)
		leucine-rich repeat	370..390	CDD:275380	4/34 (12%)
		PDZ_signaling	1359..1445	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910