DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and LRCH2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_065922.3	Gene:	LRCH2 / 57631	HGNCID:	29292	Length:	765	Species:	Homo sapiens

Alignment Length:	325	Identity:	87/325 - (26%)
Similarity:	131/325 - (40%)	Gaps:	50/325 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 GIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKR 231
            |.|.|.||:.:|.              |....|...|.....:|.....:.....|.........
Human    42 GGGTLVVPIPVPT--------------LFGQPFPNGPPWNPGSLQPQHTVRSLDRALEEAGSSGI 92

  Fly   232 LSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALA 296
            |||....|:..|...:. |...|...|:.|....:..| :.....|.||.|..|....|| .|:.
Human    93 LSLSGRKLRDFPGSGYD-LTDTTQADLSRNRFTEIPSD-VWLFAPLETLNLYHNCIKTIP-EAIK 154

  Fly   297 GLRTLEALNLGSNLLTIINDE--DFPRMPNLIVLLLKRNQIMKI--SAGALKNLTALKVLELDDN 357
            .|:.|..||:..|||:.:...  |.|    |.||::..|:::.|  ..|.||:|..   |::..|
Human   155 NLQMLTYLNISRNLLSTLPKYLFDLP----LKVLVVSNNKLVSIPEEIGKLKDLME---LDISCN 212

  Fly   358 LISSLPEGLSKLSQLQELSITSNRLRWINDT--ELPRSMQMLDMRANPLSTISPGAFRGMSKLRK 420
            .|..||:.:.||..|:||:|..|.|..:.|.  :||  :..||...|.::.| |..:|.:..|:.
Human   213 EIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLP--LVKLDFSCNKVTEI-PVCYRKLHHLQV 274

  Fly   421 LILSDVRTLRSFPELEAC-----HALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPN 480
            :|| |...|: .|..:.|     |..:.|.:...         ||...:..||:|.:.| ||:|:
Human   275 IIL-DNNPLQ-VPPAQICLKGKVHIFKYLNIQAC---------CRMDKKPDSLDLPSLS-KRMPS 327

Fly 481 480
Human 328 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/11 (45%)
		LRR_RI	180..>383	CDD:238064	53/206 (26%)
		leucine-rich repeat	183..204	CDD:275380	2/20 (10%)
		LRR_8	203..263	CDD:290566	12/59 (20%)
		leucine-rich repeat	205..228	CDD:275380	2/22 (9%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..311	CDD:290566	17/58 (29%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	19/63 (30%)
		leucine-rich repeat	301..324	CDD:275380	8/24 (33%)
		leucine-rich repeat	325..348	CDD:275380	9/24 (38%)
		LRR_RI	327..567	CDD:238064	48/163 (29%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	18/56 (32%)
		leucine-rich repeat	372..393	CDD:275380	9/22 (41%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	18/68 (26%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
LRCH2	NP_065922.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..76		4/20 (20%)
		LRR 1	89..110		5/21 (24%)
		leucine-rich repeat	92..112	CDD:275380	6/20 (30%)
		LRR 2	112..133		4/21 (19%)
		leucine-rich repeat	113..135	CDD:275380	4/22 (18%)
		LRR 3	135..156		8/21 (38%)
		LRR_RI	<136..237	CDD:238064	38/108 (35%)
		LRR_8	136..191	CDD:290566	21/59 (36%)
		LRR_4	136..173	CDD:289563	15/37 (41%)
		leucine-rich repeat	136..158	CDD:275380	9/22 (41%)
		LRR 4	158..179		6/20 (30%)
		leucine-rich repeat	159..174	CDD:275380	6/14 (43%)
		LRR 5	180..201		7/24 (29%)
		LRR_8	181..237	CDD:290566	21/58 (36%)
		leucine-rich repeat	181..203	CDD:275380	7/21 (33%)
		LRR 6	203..224		6/23 (26%)
		leucine-rich repeat	204..226	CDD:275380	8/24 (33%)
		LRR_8	226..282	CDD:290566	19/59 (32%)
		LRR 7	226..248		7/21 (33%)
		leucine-rich repeat	227..247	CDD:275380	7/19 (37%)
		leucine-rich repeat	249..271	CDD:275380	6/22 (27%)
		LRR 8	249..269		6/20 (30%)
		LRR 9	271..292		7/22 (32%)
		leucine-rich repeat	272..290	CDD:275380	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..401		6/13 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..552
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..628
		CH	644..751	CDD:278723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910