DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lgr4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	825	Identity:	184/825 - (22%)
Similarity:	299/825 - (36%)	Gaps:	272/825 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 RIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL--TALKV 351
            |:|.:.||      .|:|..|....|::..|..:|::..|:||...|.:|::.|...|  ..|:.
  Fly   182 RLPQHDLA------TLDLTGNNFETIHETFFSELPDVDSLVLKFCSIREIASHAFDRLADNPLRT 240

  Fly   352 LELDDNLISSLPEG-LSKLSQLQELSITSNRLRWINDTEL--PRSMQMLDMRANPLSTISPGAFR 413
            |.:|||.:..|||. ..:.:||..|.:..|.|..:..::.  .:.:|.||:|.|.:.......|
  Fly   241 LYMDDNKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVF- 304

  Fly   414 GMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRI 478
                                                                          .|:
  Fly   305 --------------------------------------------------------------ARL 307

  Fly   479 PNLSSCRDLRLLDLSSNQIEKIQGKPF-NGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEG 542
            ||      |.:|.|:.|.::::....| ..|..|:.|.|:||:|:.:..:.|. .|:|:.|.|.|
  Fly   308 PN------LEVLYLNENHLKRLDPDRFPRTLLNLHTLSLAYNQIEDIAANTFP-FPRLRYLFLAG 365

  Fly   543 NEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTL- 606
            |.:|:|..|.|...:.|:.|:|..|   .:....|.|...||..::..|       |..|.|||
  Fly   366 NRLSHIRDETFCNLSNLQGLHLNEN---RIEGFDLEAFACLKNLSSLLL-------TGNRFQTLD 420

  Fly   607 --------ILSYAY----HCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQ 659
                    .|.|.|    |.|                                   ::.||:
  Fly   421 SRVLKNLTSLDYIYFSWFHLC-----------------------------------SAAMNV--- 447

  Fly   660 MHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSG 724
                      .:.||                                          .|.|:.|.
  Fly   448 ----------RVCDP------------------------------------------HGDGISSK 460

  Fly   725 MSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPR 789
            :                       .|.|...||..|||:..::::||..|:......:|:.:|..
  Fly   461 L-----------------------HLLDNQILRGSVWVMASIAVVGNLLVLLGRYFYKSRSNVEH 502

  Fly   790 FL-VCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAV 853
            .| :.:|||:||.|||||.::|..|.:..||:..:...|:.|.:|..:|||:..|.:.|...|.:
  Fly   503 SLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETWRHSGVCAFAGFLSTFSCQSSTLLLTL 567

  Fly   854 ITLERNYAITHAIHLNK----RLSLKQAGYIMSVGWVFALIMALMPLV-----GVSDYRKFAVCL 909
            :|.:|..::|..:....    |:.|:     :.:.|..:..:|..||:     |...|....|||
  Fly   568 VTWDRLMSVTRPLKPRDTEKVRIVLR-----LLLLWGISFGLAAAPLLPNPYFGSHFYGNNGVCL 627

  Fly   910 ------PFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIR--GSQAWNTNDSR---IAK 963
                  |:......::|.:::    :|..:.:.::..|::|..|||  |....:|:..|   :|.
  Fly   628 SLHIHDPYAKGWEYSALLFIL----VNTLSLIFILFSYIRMLQAIRDSGGGMRSTHSGRENVVAT 688

  Fly   964 RMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDC 1028
            |.|::|.||..||.||....:.|:.|.: ||.:......|.|||:||..||.||.:.|..||:..
  Fly   689 RFAIIVTTDCACWLPIIVVKLAALSGCE-ISPDLYAWLAVLVLPVNSALNPVLYTLTTAAFKQQL 752

  Fly  1029 VTLCKHFEESRVV-----------------------GGGGPGGRG 1050
            ...|.......:|                       |||..||.|
  Fly   753 RRYCHTLPSCSLVNNETRSQTQTAYESGLSVSLAHLGGGVGGGSG 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	29/96 (30%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	7/21 (33%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380	4/10 (40%)
		LRR_8	299..359	CDD:290566	18/61 (30%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	7/24 (29%)
		LRR_RI	327..567	CDD:238064	55/245 (22%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	11/56 (20%)
		leucine-rich repeat	372..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	3/67 (4%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	19/58 (33%)
		leucine-rich repeat	487..510	CDD:275380	6/23 (26%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	18/55 (33%)
		leucine-rich repeat	535..558	CDD:275380	9/22 (41%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	35/132 (27%)
		7tm_1	770..1017	CDD:278431	76/267 (28%)
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486
		LRR_RI	<184..397	CDD:238064	65/291 (22%)
		LRR_8	188..248	CDD:290566	20/65 (31%)
		leucine-rich repeat	188..211	CDD:275380	7/28 (25%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	238..261	CDD:275380	8/22 (36%)
		LRR_8	261..320	CDD:290566	18/127 (14%)
		leucine-rich repeat	262..285	CDD:275380	4/22 (18%)
		LRR_4	284..325	CDD:289563	13/109 (12%)
		leucine-rich repeat	286..309	CDD:275380	7/85 (8%)
		LRR_4	308..348	CDD:289563	14/45 (31%)
		leucine-rich repeat	310..334	CDD:275380	6/23 (26%)
		leucine-rich repeat	335..357	CDD:275380	7/22 (32%)
		LRR_8	356..416	CDD:290566	20/69 (29%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		LRR_4	381..421	CDD:289563	14/49 (29%)
		leucine-rich repeat	382..405	CDD:275380	7/25 (28%)
		leucine-rich repeat	406..427	CDD:275380	6/27 (22%)
		7tm_1	483..741	CDD:278431	76/267 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910