DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Fili

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	130/561 - (23%)
Similarity:	215/561 - (38%)	Gaps:	157/561 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WRLALCPLLLQLLLQLLLLPPSAMGHDETKENPAPDMQNSQ--------EQEPYVHLQHLQQQQQ 65
            |.....|:||.|||.|::|||.......:|........||:        |..|.          |
  Fly    16 WLCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPI----------Q 70

  Fly    66 QNPQTVQQLSQITVNRTSKSASVTPTGIRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTA 130
            .||:|  :...:||||.
  Fly    71 LNPET--KYINLTVNRI------------------------------------------------ 85

  Fly   131 TDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLE 195
                   |||.                             .::|..:..|  :|||..|.:..|.
  Fly    86 -------RTLE-----------------------------FSLPFYMKLE--ILDLSQNIIETLG 112

  Fly   196 ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNG 260
            :.:|.....|..|.||.|.:.::..:||.||..|..|.|....::::.|.:...||.|..|.|..
  Fly   113 SKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTN 177

  Fly   261 NALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNL 325
            |.:|||:.:|...:..|..|....|....:|.:.|..|..|::|::..||:..:.::.|..:..|
  Fly   178 NNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKEL 242

  Fly   326 IVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRLRWINDTE 389
            :.|.::.|.:.::...|.:.|.:||.|:|.||.::.:| :.|||||.|..|::..||.     ::
  Fly   243 LALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRF-----SQ 302

  Fly   390 LPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTL-----RSFPELEACHALEILKL-DR 448
            ||..                 ||..:..||:|.||.:..|     |:|  ::..| |:.|.| :.
  Fly   303 LPAV-----------------AFLNLFHLRELHLSRLDFLQRIDSRAF--VDNTH-LQTLHLNNN 347

  Fly   449 AGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRD-LRLLDLSSNQIEKIQGKPFNGLKQLN 512
            ..:.::|..|.:..|.:..:.:::|||:.:.:.....| |:.|.|..|.:            |.|
  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPL------------QCN 400

  Fly   513 DLLLSYNRIKALPQDAFQGI-PKLQLLDLEGNEISYIHKEA 552
            ..||...|   |....|:|: |.::  ...|..::.:.|||
  Fly   401 CSLLWLWR---LVTGNFEGVDPGME--HAAGGAVAALAKEA 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	1/20 (5%)
		LRR_RI	180..>383	CDD:238064	62/203 (31%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	19/59 (32%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	17/58 (29%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	16/59 (27%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	60/235 (26%)
		leucine-rich repeat	349..371	CDD:275380	11/22 (50%)
		LRR_8	370..425	CDD:290566	13/54 (24%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	2/20 (10%)
		leucine-rich repeat	418..486	CDD:275380	18/73 (25%)
		leucine-rich repeat	441..464	CDD:275378	5/23 (22%)
		LRR_8	487..545	CDD:290566	14/58 (24%)
		leucine-rich repeat	487..510	CDD:275380	4/22 (18%)
		leucine-rich repeat	511..534	CDD:275380	7/23 (30%)
		LRR_8	533..589	CDD:290566	5/20 (25%)
		leucine-rich repeat	535..558	CDD:275380	4/18 (22%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	9/107 (8%)
		leucine-rich repeat	98..121	CDD:275380	7/24 (29%)
		LRR_8	120..180	CDD:404697	19/59 (32%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	59/217 (27%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	11/22 (50%)
		leucine-rich repeat	290..313	CDD:275380	8/44 (18%)
		leucine-rich repeat	314..338	CDD:275380	8/25 (32%)
		LRR_8	337..397	CDD:404697	15/60 (25%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910