DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and Fili

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster


Alignment Length:561 Identity:130/561 - (23%)
Similarity:215/561 - (38%) Gaps:157/561 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 WRLALCPLLLQLLLQLLLLPPSAMGHDETKENPAPDMQNSQ--------EQEPYVHLQHLQQQQQ 65
            |.....|:||.|||.|::|||.......:|........||:        |..|.          |
  Fly    16 WLCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPI----------Q 70

  Fly    66 QNPQTVQQLSQITVNRTSKSASVTPTGIRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTA 130
            .||:|  :...:||||.                                                
  Fly    71 LNPET--KYINLTVNRI------------------------------------------------ 85

  Fly   131 TDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLE 195
                   |||.                             .::|..:..|  :|||..|.:..|.
  Fly    86 -------RTLE-----------------------------FSLPFYMKLE--ILDLSQNIIETLG 112

  Fly   196 ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNG 260
            :.:|.....|..|.||.|.:.::..:||.||..|..|.|....::::.|.:...||.|..|.|..
  Fly   113 SKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTN 177

  Fly   261 NALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNL 325
            |.:|||:.:|...:..|..|....|....:|.:.|..|..|::|::..||:..:.::.|..:..|
  Fly   178 NNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKEL 242

  Fly   326 IVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRLRWINDTE 389
            :.|.::.|.:.::...|.:.|.:||.|:|.||.::.:| :.|||||.|..|::..||.     ::
  Fly   243 LALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRF-----SQ 302

  Fly   390 LPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTL-----RSFPELEACHALEILKL-DR 448
            ||..                 ||..:..||:|.||.:..|     |:|  ::..| |:.|.| :.
  Fly   303 LPAV-----------------AFLNLFHLRELHLSRLDFLQRIDSRAF--VDNTH-LQTLHLNNN 347

  Fly   449 AGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRD-LRLLDLSSNQIEKIQGKPFNGLKQLN 512
            ..:.::|..|.:..|.:..:.:::|||:.:.:.....| |:.|.|..|.:            |.|
  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPL------------QCN 400

  Fly   513 DLLLSYNRIKALPQDAFQGI-PKLQLLDLEGNEISYIHKEA 552
            ..||...|   |....|:|: |.::  ...|..::.:.|||
  Fly   401 CSLLWLWR---LVTGNFEGVDPGME--HAAGGAVAALAKEA 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 1/20 (5%)
LRR_RI 180..>383 CDD:238064 62/203 (31%)
leucine-rich repeat 183..204 CDD:275380 6/20 (30%)
LRR_8 203..263 CDD:290566 19/59 (32%)
leucine-rich repeat 205..228 CDD:275380 9/22 (41%)
leucine-rich repeat 229..252 CDD:275380 5/22 (23%)
LRR_8 252..311 CDD:290566 17/58 (29%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 6/22 (27%)
LRR_8 299..359 CDD:290566 16/59 (27%)
leucine-rich repeat 301..324 CDD:275380 5/22 (23%)
leucine-rich repeat 325..348 CDD:275380 5/22 (23%)
LRR_RI 327..567 CDD:238064 60/235 (26%)
leucine-rich repeat 349..371 CDD:275380 11/22 (50%)
LRR_8 370..425 CDD:290566 13/54 (24%)
leucine-rich repeat 372..393 CDD:275380 6/20 (30%)
leucine-rich repeat 394..415 CDD:275380 2/20 (10%)
leucine-rich repeat 418..486 CDD:275380 18/73 (25%)
leucine-rich repeat 441..464 CDD:275378 5/23 (22%)
LRR_8 487..545 CDD:290566 14/58 (24%)
leucine-rich repeat 487..510 CDD:275380 4/22 (18%)
leucine-rich repeat 511..534 CDD:275380 7/23 (30%)
LRR_8 533..589 CDD:290566 5/20 (25%)
leucine-rich repeat 535..558 CDD:275380 4/18 (22%)
leucine-rich repeat 559..580 CDD:275380
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 9/107 (8%)
leucine-rich repeat 98..121 CDD:275380 7/24 (29%)
LRR_8 120..180 CDD:404697 19/59 (32%)
leucine-rich repeat 122..145 CDD:275380 9/22 (41%)
leucine-rich repeat 146..169 CDD:275380 5/22 (23%)
LRR <161..>354 CDD:227223 59/217 (27%)
leucine-rich repeat 170..193 CDD:275380 8/22 (36%)
leucine-rich repeat 194..217 CDD:275380 6/22 (27%)
leucine-rich repeat 218..265 CDD:275380 10/46 (22%)
leucine-rich repeat 266..289 CDD:275380 11/22 (50%)
leucine-rich repeat 290..313 CDD:275380 8/44 (18%)
leucine-rich repeat 314..338 CDD:275380 8/25 (32%)
LRR_8 337..397 CDD:404697 15/60 (25%)
leucine-rich repeat 339..360 CDD:275380 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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