DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lrrtm1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_005160139.1	Gene:	lrrtm1 / 570385	ZFINID:	ZDB-GENE-050506-80	Length:	524	Species:	Danio rerio

Alignment Length:	573	Identity:	129/573 - (22%)
Similarity:	215/573 - (37%)	Gaps:	141/573 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|...    :|.|.|:.:..:|.|| :..:.|.|..||:::|...:|.....|..|.|..|:|.
Zfish    45 CRCDNK----QLYCEGLNLTDIPQNL-SSAIGLSLRENNISELREGNFVGLSQLTWLYLDHNNIE 104

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .::.:||..|.::|.|.|....::|||..:|:.|..|..|.|:.|.|.||:.|....|:||..|.
Zfish   105 IVEESAFERLRRIKELDLSTNRIESLPNGTFRPLPNLRILDLSYNRLQSLEPDLFHGLRKLTNLH 169

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |..|....||.......|:::.|:||.|.|..:....|..:..|..|.|:.|:::|::......|
Zfish   170 LRYNALKFIPVRIFQDCRSMQFLDLGYNQLQSLARNSFAGLFKLTELHLEHNELVKVNLAHFPRL 234

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGA 411
            .:|:.|.:.:|                :.:|..|.|.|..|     .::.:|...|.:..|.|..
Zfish   235 ISLRTLYMRNN----------------KATIVVNTLEWTWD-----YLEKIDFSNNEIEYIEPHV 278

  Fly   412 FRGMSKLRKLILS-------DVRTLRSFPELEACHALEILKLDRAGIQ-EVPANLCRQTPRLKSL 468
            |..:.||..|:|.       |.|.|.|:..|.:        :..:|.. |...|:|.....|.:.
Zfish   279 FESVPKLNTLMLDSNKLTYIDQRILDSWTSLSS--------ITLSGNDWECSRNVCALASWLSNF 335

  Fly   469 ELKTNS--LKRIPNLSSCRDLRLLD------LSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALP 525
            :.:.:|  |...|:::...|  :||      |..:.:|          .......::.||.:..
Zfish   336 QGQRDSGLLCANPDIAQGED--ILDAVYAFQLCEDNVE----------ATTQTFTVTRNRPRGF- 387

  Fly   526 QDAFQGIPK--LQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNN 588
              .::|..|  ..|.|:||.|:.   ..:.:...:.:||.....|...:  :|..||:.
Zfish   388 --IYEGPTKNPYDLQDMEGGEVV---TNSLTVTASADDLESTMKIHKVV--TGTMALIF------ 439

  Fly   589 PKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSM 653
                      :| .|..|:|..::.|  |...|....|..|||
Zfish   440 ----------SF-LIMVLMLYVSWKC--FPAGVRQLRQCFTSQ---------------------- 469

  Fly   654 MNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEH 706
                                        ..:|.|.||..|:||:...||:.::
Zfish   470 ----------------------------RRKQKQKQTMQQMATTSASEYYVDY 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	56/202 (28%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	16/59 (27%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	51/257 (20%)
		leucine-rich repeat	349..371	CDD:275380	3/21 (14%)
		LRR_8	370..425	CDD:290566	14/61 (23%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	16/77 (21%)
		leucine-rich repeat	441..464	CDD:275378	4/23 (17%)
		LRR_8	487..545	CDD:290566	12/65 (18%)
		leucine-rich repeat	487..510	CDD:275380	4/28 (14%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	12/57 (21%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrtm1	XP_005160139.1	LRR_8	72..127	CDD:290566	17/54 (31%)
		leucine-rich repeat	72..92	CDD:275380	6/19 (32%)
		LRR_RI	90..322	CDD:238064	69/260 (27%)
		leucine-rich repeat	93..116	CDD:275380	8/22 (36%)
		LRR_8	115..175	CDD:290566	22/59 (37%)
		leucine-rich repeat	117..140	CDD:275380	8/22 (36%)
		leucine-rich repeat	141..164	CDD:275380	9/22 (41%)
		leucine-rich repeat	165..188	CDD:275380	6/22 (27%)
		leucine-rich repeat	189..212	CDD:275380	6/22 (27%)
		LRR_8	192..246	CDD:290566	15/69 (22%)
		leucine-rich repeat	213..236	CDD:275380	6/22 (27%)
		leucine-rich repeat	237..259	CDD:275380	7/37 (19%)
		LRR_8	261..318	CDD:290566	15/64 (23%)
		leucine-rich repeat	261..284	CDD:275380	5/22 (23%)
		leucine-rich repeat	285..305	CDD:275380	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910