DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP008171

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001689016.1	Gene:	AgaP_AGAP008171 / 5668341	VectorBaseID:	AGAP008171	Length:	680	Species:	Anopheles gambiae

Alignment Length:	586	Identity:	135/586 - (23%)
Similarity:	236/586 - (40%)	Gaps:	135/586 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 LDLGNNNLTKLEANSFFMA----PNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPP 244
            :||..|.|..|..:|...|    |.|.:|.|.:|.:.:::.:.|..:..|.|:.|.:..:..:..
Mosquito   104 IDLSKNRLHTLYDSSAGTATLSYPLLADLYLRENKLKHINLDVFRPMESLTRIDLSHNQISVVSG 168

  Fly   245 QSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSN 309
            ....  |.|..|.|:.|.:|.:  ||.|               :.:|.     |..::|
Mosquito   169 SLVS--ASLNLLDLSNNRIVEM--DCCG---------------WAVPM-----LYGMDA------ 203

  Fly   310 LLTIINDEDFPRMP--------NLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGL 366
                 ||.....:|        |::.|...|||:..........||:||.|.|.||.:..:...:
Mosquito   204 -----NDNRLRALPKCLEQAFLNVVRLAFDRNQLQPDVMFQFGRLTSLKFLTLTDNKLPYVTLNM 263

  Fly   367 SKL-SQLQELSITSNRLRWINDTELP----------------------RSMQMLDMRANPLS--- 405
            |.: .||:.|:::.|:|:.::....|                      .::..|.|..|||.
Mosquito   264 STIPKQLRHLNLSHNKLKHLDVPYAPSKDFHIDVSSNCISSVDWDRVSANLTKLGMGENPLDCSF 328

  Fly   406 -TISPGA---------FR--GMSKLRKLILSDVR---------TLRSFPELEA-------CHALE 442
             :||..|         ||  .::||...:|..|:         |::..|..:|       ..:|.
Mosquito   329 HSISTRADIRSKLHIHFRYLNVTKLHSDLLDRVKLSNDETLQATIQHSPIQQAYLSSRTNITSLL 393

  Fly   443 ILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLR-LLDLSSNQIEKIQGKPFN 506
            :|..:.:.|:..|.|     |:|:.|.:..:.|:.:|:  |.:.|. :|:|..|:|..:.....:
Mosquito   394 LLDTNLSDIEIEPHN-----PKLEILTIMKSRLRCVPD--SIKQLAVVLNLMQNKISFLNYSCSS 451

  Fly   507 GLK--QLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIF 569
            |::  .|..:.|::|.:..:..:.|.|:..|.:|||..|.:..:  |.....::|.||.|.:|.|
Mosquito   452 GVEFPSLRVIYLAHNLLTTIGMNDFNGMKLLNILDLSNNSLHSL--EGQLRLSSLTDLKLSHNHF 514

  Fly   570 PELPESG--LRALLHLKTFNNPKLREFPP--PDTFPRIQTL-----ILSY------AYHCCAFLP 619
            .||...|  |.:|.:| ..||..|:..|.  .|..|.:..|     :||.      .....:.|.
Mosquito   515 TELSCCGWNLSSLTNL-DINNNTLQRLPTCMEDALPIVSYLNLVSNVLSNDDNIWDRLASLSQLT 578

  Fly   620 LVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSM--MNIWPQMHNLSKQLGASMHDPWE-TAINF 681
            |:.:|..:.||.|.:.|...:..   :.|.||.|  :||...:...:..:|.:..|..| ::.:|
Mosquito   579 LLDLSYNRLTSMVWDNVTLSTRY---INLRNNPMKYLNIPMAIDGFNVDMGCTTFDQLEISSRSF 640

  Fly   682 N 682
            |
Mosquito   641 N 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	49/211 (23%)
		leucine-rich repeat	183..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	14/59 (24%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	3/22 (14%)
		LRR_8	252..311	CDD:290566	11/58 (19%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	2/22 (9%)
		LRR_8	299..359	CDD:290566	17/67 (25%)
		leucine-rich repeat	301..324	CDD:275380	4/30 (13%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	68/296 (23%)
		leucine-rich repeat	349..371	CDD:275380	7/22 (32%)
		LRR_8	370..425	CDD:290566	19/91 (21%)
		leucine-rich repeat	372..393	CDD:275380	5/42 (12%)
		leucine-rich repeat	394..415	CDD:275380	10/35 (29%)
		leucine-rich repeat	418..486	CDD:275380	17/83 (20%)
		leucine-rich repeat	441..464	CDD:275378	5/22 (23%)
		LRR_8	487..545	CDD:290566	16/60 (27%)
		leucine-rich repeat	487..510	CDD:275380	6/25 (24%)
		leucine-rich repeat	511..534	CDD:275380	5/22 (23%)
		LRR_8	533..589	CDD:290566	19/57 (33%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	10/22 (45%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP008171	XP_001689016.1	leucine-rich repeat	103..128	CDD:275380	7/23 (30%)
		LRR_8	127..185	CDD:290566	14/59 (24%)
		leucine-rich repeat	129..152	CDD:275380	5/22 (23%)
		leucine-rich repeat	153..174	CDD:275380	3/22 (14%)
		leucine-rich repeat	175..197	CDD:275380	8/38 (21%)
		leucine-rich repeat	198..224	CDD:275380	6/36 (17%)
		leucine-rich repeat	225..245	CDD:275380	5/19 (26%)
		leucine-rich repeat	246..269	CDD:275380	7/22 (32%)
		leucine-rich repeat	270..294	CDD:275380	5/23 (22%)
		leucine-rich repeat	411..430	CDD:275380	5/20 (25%)
		leucine-rich repeat	434..457	CDD:275378	5/22 (23%)
		LRR_RI	<456..588	CDD:238064	35/134 (26%)
		LRR_8	456..514	CDD:290566	16/59 (27%)
		leucine-rich repeat	458..481	CDD:275380	5/22 (23%)
		LRR	<482..>614	CDD:227223	38/137 (28%)
		leucine-rich repeat	482..503	CDD:275380	6/22 (27%)
		leucine-rich repeat	504..526	CDD:275380	10/21 (48%)
		leucine-rich repeat	527..550	CDD:275380	7/23 (30%)
		leucine-rich repeat	551..576	CDD:275380	3/24 (13%)
		leucine-rich repeat	577..599	CDD:275380	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910