DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and AgaP_AGAP007037

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001688065.1	Gene:	AgaP_AGAP007037 / 5666906	VectorBaseID:	AGAP007037	Length:	489	Species:	Anopheles gambiae

Alignment Length:	369	Identity:	102/369 - (27%)
Similarity:	171/369 - (46%)	Gaps:	50/369 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 IINMDPNA---FYGLAKLKRLSL--QNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHL 274
            ||..:.:|   |:|:......|:  ::..:..||.:.|:...          |:..|..|.. |:
Mosquito    45 IIRSEADADSIFFGVQNFNDTSIAFRDSSMVLLPKKIFETFP----------AIQYLSSDAC-HI 98

  Fly   275 QKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKIS 339
            |||.     |..|        |..:.|:.|:|..|.||.:|:..|.....|.:|.|..|.|.::.
Mosquito    99 QKLL-----GGTF--------ANAQRLQELHLYDNRLTRLNNFVFNGALQLEILSLYNNTIKQLE 150

  Fly   340 AGALKNLTALKVLELDDNLISSLPEGL-SKLSQLQELSITSNRLRWINDTE--LPRSMQMLDMRA 401
            ..|...|..|::|.:|:|.:..||||| |.|.:||.|.:..||::.|||.:  |...::.|::.|
Mosquito   151 EHAFDGLGHLRLLYMDENQLEKLPEGLFSGLEELQILELQHNRIKEINDDQFVLCPMLRELNLSA 215

  Fly   402 NPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTP--R 464
            |.:||.:....:.::||..|.::     |::  |:.....:.|:...|...::...:..|..  :
Mosquito   216 NMISTFNMSQLQSLNKLETLDIA-----RNY--LDEVFVTKYLRTLNAQENQISRIVMDQGDFFQ 273

  Fly   465 LKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAF 529
            |..|.|..|::..|.|:...|:|..||:|.|::..:....|..:|.|.|:.|:.||:..|.
Mosquito   274 LTHLNLSRNNIANINNIFKFRNLIELDVSYNELVTLDFVIFAFMKNLKDIKLNNNRLWILD---- 334

  Fly   530 QGIP----KLQLLDLEGNEISYIHKEAFSGFTALEDLNL-GNNI 568
            .|||    .|:.|:|..|:..|:.......|.|||.:.| ||::
Mosquito   335 NGIPSPAKSLRSLNLAHNKFLYLDLAVLDTFPALEYIYLHGNDL 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	50/173 (29%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	9/52 (17%)
		leucine-rich repeat	205..228	CDD:275380	5/15 (33%)
		leucine-rich repeat	229..252	CDD:275380	4/24 (17%)
		LRR_8	252..311	CDD:290566	14/58 (24%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	73/249 (29%)
		leucine-rich repeat	349..371	CDD:275380	11/22 (50%)
		LRR_8	370..425	CDD:290566	17/56 (30%)
		leucine-rich repeat	372..393	CDD:275380	9/22 (41%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	13/69 (19%)
		leucine-rich repeat	441..464	CDD:275378	3/24 (13%)
		LRR_8	487..545	CDD:290566	20/61 (33%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	9/26 (35%)
		LRR_8	533..589	CDD:290566	13/41 (32%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	5/11 (45%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP007037	XP_001688065.1	leucine-rich repeat	88..111	CDD:275380	9/36 (25%)
		LRR_8	111..170	CDD:290566	19/58 (33%)
		leucine-rich repeat	112..135	CDD:275380	8/22 (36%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		LRR_8	159..218	CDD:290566	23/58 (40%)
		leucine-rich repeat	160..183	CDD:275380	11/22 (50%)
		leucine-rich repeat	184..207	CDD:275380	9/22 (41%)
		leucine-rich repeat	208..231	CDD:275380	5/22 (23%)
		leucine-rich repeat	232..250	CDD:275380	4/24 (17%)
		leucine-rich repeat	251..295	CDD:275380	9/43 (21%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	318..378	CDD:290566	22/63 (35%)
		leucine-rich repeat	320..343	CDD:275380	9/26 (35%)
		leucine-rich repeat	368..392	CDD:275378	5/11 (45%)
		leucine-rich repeat	393..406	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910