DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and APL1A

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001688066.1	Gene:	APL1A / 5666905	VectorBaseID:	AGAP007036	Length:	428	Species:	Anopheles gambiae

Alignment Length:	465	Identity:	118/465 - (25%)
Similarity:	192/465 - (41%)	Gaps:	98/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 WLQKHCHCTGSLEVLRLSCRGIG---ILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAP----- 203
            ||:    ....:.|:.|:|...|   ..:.|:          .||..........:::.|
Mosquito     3 WLR----AVSQISVIFLACTNGGQPSYRSQPI----------YGNKQRYYGNQQYYYVKPLQPEY 53

  Fly   204 -----NLEELTLSDNSIINM-DPNAFYG-----LAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQ 257
                 ||:...:..|..|:| ..:.::|     |...|.::.:|..::.||..|.....|:..|.
Mosquito    54 KCIEKNLQYDCVFYNVHIDMQSQDVYFGFDDITLNNQKNVTFKNSTMRKLPAASLASFRQVEVLN 118

  Fly   258 LNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRM 322
            |||                   |::|     .|.|||.|...|::.|.:|.|.:..:....|..:
Mosquito   119 LNG-------------------LQIE-----EIDTNAFAYAHTIQKLYMGFNAIRYLPPHVFQNV 159

  Fly   323 PNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSL-PEGLSKLSQLQELSITSNRLRWIN 386
            |:|.||:|:||.:..:..|...|...|.:|.:.:|.:..: .|.....:.||.|.::||||..:
Mosquito   160 PSLTVLVLERNDLTSLPRGIFHNTPKLTMLSMSNNNLERIEDETFQATTTLQNLQLSSNRLTHV- 223

  Fly   387 DTELPRSMQMLDMRANPLSTIS-PGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAG 450
            |..|..|:..:::..|.|||:: |.|..                    ||:|.|         ..
Mosquito   224 DLALIPSLFHVNVSYNLLSTLAIPIAVE--------------------ELDASH---------NS 259

  Fly   451 IQEV--PANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLND 513
            |..|  |.|:     .|..|:|:.|:|.....|.:...|..:|||.|::|||..:.|..:::|..
Mosquito   260 INAVRGPVNM-----ELTILKLQHNNLTDTAWLLNYPGLVEVDLSYNELEKIMYRYFVKMQRLER 319

  Fly   514 LLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLR 578
            |.:|.||:.||.... |.||.|::|||..|.:.::.:.. ..|..||:|.|.:|....|..|...
Mosquito   320 LYVSNNRLVALNLYG-QPIPTLKVLDLSHNHLLHVERNQ-PQFDRLENLYLDHNSIVTLNLSTSH 382

  Fly   579 ALLHLKTFNN 588
            .|.:||..:|
Mosquito   383 TLKNLKLSHN 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/23 (22%)
		LRR_RI	180..>383	CDD:238064	51/219 (23%)
		leucine-rich repeat	183..204	CDD:275380	3/30 (10%)
		LRR_8	203..263	CDD:290566	18/75 (24%)
		leucine-rich repeat	205..228	CDD:275380	6/28 (21%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	16/58 (28%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	17/59 (29%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	70/243 (29%)
		leucine-rich repeat	349..371	CDD:275380	4/22 (18%)
		LRR_8	370..425	CDD:290566	16/55 (29%)
		leucine-rich repeat	372..393	CDD:275380	9/20 (45%)
		leucine-rich repeat	394..415	CDD:275380	6/21 (29%)
		leucine-rich repeat	418..486	CDD:275380	14/69 (20%)
		leucine-rich repeat	441..464	CDD:275378	4/24 (17%)
		LRR_8	487..545	CDD:290566	24/57 (42%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	18/56 (32%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
APL1A	XP_001688066.1	LRR_8	112..172	CDD:290566	24/83 (29%)
		leucine-rich repeat	114..137	CDD:275380	11/46 (24%)
		leucine-rich repeat	138..161	CDD:275380	4/22 (18%)
		LRR_RI	160..402	CDD:238064	79/270 (29%)
		LRR_8	160..220	CDD:290566	18/59 (31%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		leucine-rich repeat	186..209	CDD:275380	4/22 (18%)
		leucine-rich repeat	210..230	CDD:275380	9/20 (45%)
		leucine-rich repeat	231..255	CDD:275380	8/43 (19%)
		LRR_8	270..327	CDD:290566	19/56 (34%)
		leucine-rich repeat	271..292	CDD:275380	6/20 (30%)
		leucine-rich repeat	293..316	CDD:275380	9/22 (41%)
		LRR_8	316..373	CDD:290566	21/58 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910