DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and lingo1a

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:XP_005174327.1 Gene:lingo1a / 564943 ZFINID:ZDB-GENE-080327-16 Length:615 Species:Danio rerio


Alignment Length:591 Identity:146/591 - (24%)
Similarity:234/591 - (39%) Gaps:122/591 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|  :::...:.|....:::||..:|:|..:|||..|.:..:..:.|...|.||||.|::|:|.
Zfish    39 CEC--NVQERSVLCHRKKLMSVPEGIPSETRLLDLSKNRIKTINPDEFSAFPQLEELELNENTIS 101

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .::|.||..|..|:.|.|::..||.:....|.||:.||.|.::.|.:|.|.......|..||:|.
Zfish   102 AIEPGAFNNLYGLQTLGLRSNKLKLIQLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLRSLE 166

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            :..|....|...|..||.:||.|.|....||.:..|.|..:.:|:.|.|:...|..|...:.|.|
Zfish   167 VGDNDLVFISHRAFHGLSSLEQLTLEKCNLTSVPTEAFTHLHSLVTLRLRNLNINSIRDYSFKRL 231

  Fly   347 TALKVLELD-----DNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPR-------SMQMLDM 399
            ..|||||:.     |.:.::...||:    |..|:||:..|     |.:|.       .::.|:|
Zfish   232 YRLKVLEIANWPYLDTMTTNCLYGLN----LTSLTITNANL-----TSIPYLALRHLVYLRFLNM 287

  Fly   400 RANP------------------------LSTISPGAFRGMSKLRKLILSD--VRTL-----RSFP 433
            ..||                        ||.|.|.:|||::.|:.|.:|.  :.||     .|..
Zfish   288 SYNPIQMIEGNRLHDLLRLQELYLVGGRLSVIEPYSFRGLNYLKVLNVSSNFLTTLEESVFHSVG 352

  Fly   434 ELEA-----------CHALEILKLDRAGIQEVPANLCRQTPRLKSLE-LKTNSLKRI-----PNL 481
            .||.           |..|.:.:      :....|..||.|...|.| ::....|..     ||.
Zfish   353 NLETLALHDNPLACDCRLLWVFR------RRWRLNFNRQQPTCSSPEFVQGKEFKDFPDILQPNY 411

  Fly   482 SSCRDLRLLDLSSNQ-----------IEKIQGKPFNGLKQLND-----LLLSYNRIKALPQDAFQ 530
            .:||..|:.|....|           :.:..|.|...:..|:.     .:.:..|:...|    .
Zfish   412 FTCRKSRIRDRKPQQKFVDEGTTVHFVCQADGDPTPVIMWLSPQKQFITMKTIGRLTVFP----D 472

  Fly   531 GIPKLQLLDLEGN-EISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTF-NNPKLRE 593
            |..:::...::.| ....|...|....|||..|:: ::..|:.|....:.|..:... |:..:.|
Zfish   473 GTLEVRYAQIQDNGTYGCIASNAGGNDTALAHLHV-HSYSPDWPNQPNKTLAFISNQPNDNSINE 536

  Fly   594 FPPPDTFP-RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIW 657
            ......|| .|:|||::......:||.:|....         .:||         ||:....|  
Zfish   537 TRATVPFPFDIKTLIIATTMGFISFLGVVLFCL---------VLLF---------LWSRGKGN-- 581

  Fly   658 PQMHNL 663
             ..||:
Zfish   582 -SKHNI 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 3/20 (15%)
LRR_RI 180..>383 CDD:238064 68/207 (33%)
leucine-rich repeat 183..204 CDD:275380 5/20 (25%)
LRR_8 203..263 CDD:290566 24/59 (41%)
leucine-rich repeat 205..228 CDD:275380 11/22 (50%)
leucine-rich repeat 229..252 CDD:275380 8/22 (36%)
LRR_8 252..311 CDD:290566 19/58 (33%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR_8 299..359 CDD:290566 21/64 (33%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
leucine-rich repeat 325..348 CDD:275380 7/22 (32%)
LRR_RI 327..567 CDD:238064 69/316 (22%)
leucine-rich repeat 349..371 CDD:275380 8/26 (31%)
LRR_8 370..425 CDD:290566 20/85 (24%)
leucine-rich repeat 372..393 CDD:275380 7/27 (26%)
leucine-rich repeat 394..415 CDD:275380 10/44 (23%)
leucine-rich repeat 418..486 CDD:275380 20/91 (22%)
leucine-rich repeat 441..464 CDD:275378 4/22 (18%)
LRR_8 487..545 CDD:290566 10/74 (14%)
leucine-rich repeat 487..510 CDD:275380 5/33 (15%)
leucine-rich repeat 511..534 CDD:275380 4/27 (15%)
LRR_8 533..589 CDD:290566 11/57 (19%)
leucine-rich repeat 535..558 CDD:275380 3/23 (13%)
leucine-rich repeat 559..580 CDD:275380 4/20 (20%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
lingo1aXP_005174327.1 LRRNT 34..68 CDD:214470 7/30 (23%)
LRR_RI <55..231 CDD:238064 58/175 (33%)
leucine-rich repeat 66..89 CDD:275380 5/22 (23%)
LRR_8 88..148 CDD:290566 24/59 (41%)
leucine-rich repeat 90..113 CDD:275380 11/22 (50%)
leucine-rich repeat 114..137 CDD:275380 8/22 (36%)
LRR_8 136..196 CDD:290566 19/59 (32%)
leucine-rich repeat 138..185 CDD:275380 15/46 (33%)
LRR_8 184..241 CDD:290566 20/56 (36%)
leucine-rich repeat 186..209 CDD:275380 8/22 (36%)
leucine-rich repeat 210..257 CDD:275380 14/46 (30%)
leucine-rich repeat 234..256 CDD:275380 6/21 (29%)
LRR_8 257..316 CDD:290566 11/67 (16%)
leucine-rich repeat 258..281 CDD:275380 7/27 (26%)
leucine-rich repeat 282..305 CDD:275380 4/22 (18%)
LRR_8 305..364 CDD:290566 15/58 (26%)
leucine-rich repeat 306..329 CDD:275380 7/22 (32%)
leucine-rich repeat 330..350 CDD:275380 5/19 (26%)
TPKR_C2 362..>398 CDD:301599 8/41 (20%)
I-set 421..507 CDD:254352 15/89 (17%)
Ig 432..507 CDD:299845 13/78 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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