DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lrrc4cb

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_005166545.1	Gene:	lrrc4cb / 564462	ZFINID:	ZDB-GENE-080327-5	Length:	631	Species:	Danio rerio

Alignment Length:	317	Identity:	85/317 - (26%)
Similarity:	140/317 - (44%)	Gaps:	73/317 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 LNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEG-LS 367
            |||..|.:.:|..:.|..:.:|.:|.|.||.|..|..||...||:|..|||.||.::::|.| ..
Zfish    82 LNLQDNQIQVIKVDSFKHLRHLEILQLSRNHIRNIEIGAFNGLTSLNTLELFDNRLTTIPNGAFE 146

  Fly   368 KLSQLQELSITSNRLRWINDTELPR--SMQMLDM-RANPLSTISPGAFRGMSKLRKLILSDVRTL 429
            .||:|:||.:.:|.:..|......|  |::.||: ....||.||.|||:|:|.||.|.|
Zfish   147 YLSKLKELWLRNNPIESIPSDAFSRLPSLRRLDLGELKRLSYISSGAFQGLSNLRYLNL------ 205

  Fly   430 RSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSS 494
                                       .:|              :||.:||:.....|..|::|.
Zfish   206 ---------------------------GMC--------------NLKEVPNIQPLIRLDELEMSG 229

  Fly   495 NQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTAL 559
            ||:..||...|.||..|..|.:.:.:::.:.:::|..:..|:.|:|..|.::::..:.::....|
Zfish   230 NQLTVIQPSSFKGLVHLQKLWMMHAQVQTIERNSFDDLHSLRELNLAHNNLTFLPHDLYTPLHHL 294

  Fly   560 EDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCA 616
            :.::|.:|     |.:....:|.|..:    |||..|.:|             .|||
Zfish   295 QRVHLHHN-----PWNCNCDILWLSWW----LRETVPTNT-------------SCCA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	31/79 (39%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	4/6 (67%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	23/54 (43%)
		leucine-rich repeat	301..324	CDD:275380	6/19 (32%)
		leucine-rich repeat	325..348	CDD:275380	10/22 (45%)
		LRR_RI	327..567	CDD:238064	66/243 (27%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		LRR_8	370..425	CDD:290566	23/57 (40%)
		leucine-rich repeat	372..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..415	CDD:275380	9/21 (43%)
		leucine-rich repeat	418..486	CDD:275380	9/67 (13%)
		leucine-rich repeat	441..464	CDD:275378	1/22 (5%)
		LRR_8	487..545	CDD:290566	17/57 (30%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	10/55 (18%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc4cb	XP_005166545.1	LRRNT	48..81	CDD:214470
		LRR_8	77..137	CDD:290566	23/54 (43%)
		leucine-rich repeat	79..102	CDD:275380	6/19 (32%)
		LRR_RI	82..>281	CDD:238064	71/245 (29%)
		leucine-rich repeat	103..126	CDD:275380	10/22 (45%)
		LRR_8	125..180	CDD:290566	19/54 (35%)
		leucine-rich repeat	127..150	CDD:275380	9/22 (41%)
		leucine-rich repeat	151..174	CDD:275380	6/22 (27%)
		leucine-rich repeat	175..199	CDD:275380	10/23 (43%)
		leucine-rich repeat	200..221	CDD:275380	9/67 (13%)
		LRR_8	221..280	CDD:290566	17/58 (29%)
		leucine-rich repeat	222..245	CDD:275380	10/22 (45%)
		leucine-rich repeat	246..269	CDD:275380	3/22 (14%)
		leucine-rich repeat	270..291	CDD:275380	4/20 (20%)
		LRRCT	302..352	CDD:214507	12/50 (24%)
		I-set	355..443	CDD:254352
		Ig	372..439	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910