DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lrrc8db

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001070848.1	Gene:	lrrc8db / 563923	ZFINID:	ZDB-GENE-061013-487	Length:	841	Species:	Danio rerio

Alignment Length:	528	Identity:	125/528 - (23%)
Similarity:	200/528 - (37%)	Gaps:	156/528 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LYEKSLQEYHGSQLSTASTATDVIAGKR----TLH----------------------------SI 143
            |:.:.|:||...::...|:.:|:...|.    .||                            |:
Zfish   370 LFRRPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISL 434

  Fly   144 CERW----LQKHC--HCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMA 202
            ...|    |::|.  :....||:......|:         |:  .|.||.:..:.|||     :.
Zfish   435 NHEWTFEKLRQHVTRNAQDKLELHLFMLSGV---------PD--AVFDLTDIEVLKLE-----LI 483

  Fly   203 PNLEELTLSDNSIINMDPNAFYGL-AKLKR--LSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALV 264
            |. ..:|...:.:||:....||.. ||:::  .|.....|:.|..: |..:|::.:
Zfish   484 PE-ARITAKISQMINLTELHFYHCPAKVEQTAFSFLRDHLRCLHVK-FTDVAEIPT--------- 537

  Fly   265 SLDGDCLGHLQKLRTLRLEGNLFYR----IPTNALAGLRTLEALNLGSNLLTI-INDEDFPRMPN 324
                 .:..|:.||.|.|.|||...    |...:|..||.|:.|:|.|||..| .|..|.  .|:
Zfish   538 -----WVYMLKNLRELYLVGNLNSENNKMIGLESLRDLRHLKVLHLKSNLTKIPTNITDL--SPH 595

  Fly   325 LIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTE 389
            ||.|::..:....:...:||.:..|..|||.:..:..:|..:..|:.||||.:.||.:|.|.:
Zfish   596 LIKLVVHNDGTKLLVLNSLKKMMNLSDLELHNCELERIPHAIFSLTNLQELDLKSNNIRTIEE-- 658

  Fly   390 LPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEV 454
                                                   :.||..|:
Zfish   659 ---------------------------------------VISFQHLK------------------ 666

  Fly   455 PANLCRQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSY 518
                     ||..|:|..|.:..|| ::|..::|..|.||.|::|.:....||.|| |..|.:|:
Zfish   667 ---------RLNCLKLWHNKIISIPLSISHVKNLEFLYLSHNKLESLPTTLFNLLK-LRYLDVSH 721

  Fly   519 NRIKALPQD-AFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPE--SGLRAL 580
            |.|..:|.: .|  :..||...:.||::..:.|:.|. .|.|..|:||:|....|||  ..|..|
Zfish   722 NSIVVIPPEVGF--LQNLQHFAITGNKVEVVPKQLFK-CTKLRTLSLGHNCISSLPEKIGQLLQL 783

  Fly   581 LHLKTFNN 588
            .||:...|
Zfish   784 THLELKGN 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/20 (15%)
		LRR_RI	180..>383	CDD:238064	58/210 (28%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	13/62 (21%)
		leucine-rich repeat	205..228	CDD:275380	5/23 (22%)
		leucine-rich repeat	229..252	CDD:275380	4/24 (17%)
		LRR_8	252..311	CDD:290566	17/62 (27%)
		leucine-rich repeat	253..276	CDD:275380	1/22 (5%)
		leucine-rich repeat	277..300	CDD:275380	10/26 (38%)
		LRR_8	299..359	CDD:290566	20/60 (33%)
		leucine-rich repeat	301..324	CDD:275380	9/23 (39%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	56/241 (23%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	8/54 (15%)
		leucine-rich repeat	372..393	CDD:275380	8/20 (40%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	11/68 (16%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	21/58 (36%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	7/23 (30%)
		LRR_8	533..589	CDD:290566	20/58 (34%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	9/22 (41%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc8db	NP_001070848.1	Pannexin_like	1..367	CDD:289311
		leucine-rich repeat	498..521	CDD:275380	5/22 (23%)
		leucine-rich repeat	522..541	CDD:275380	4/33 (12%)
		LRR_RI	<544..821	CDD:238064	88/322 (27%)
		leucine-rich repeat	545..572	CDD:275380	10/26 (38%)
		leucine-rich repeat	573..619	CDD:275380	15/47 (32%)
		leucine-rich repeat	597..611	CDD:275380	2/13 (15%)
		leucine-rich repeat	620..642	CDD:275380	6/21 (29%)
		LRR_8	641..701	CDD:290566	24/127 (19%)
		leucine-rich repeat	643..667	CDD:275380	11/91 (12%)
		leucine-rich repeat	668..690	CDD:275380	7/21 (33%)
		LRR_8	689..747	CDD:290566	21/60 (35%)
		LRR_4	689..729	CDD:289563	15/40 (38%)
		leucine-rich repeat	691..713	CDD:275380	8/21 (38%)
		leucine-rich repeat	714..736	CDD:275380	7/23 (30%)
		LRR_8	736..791	CDD:290566	19/55 (35%)
		leucine-rich repeat	737..759	CDD:275380	6/22 (27%)
		leucine-rich repeat	760..782	CDD:275380	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910