DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and opn4xb

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001245152.1	Gene:	opn4xb / 563080	ZFINID:	ZDB-GENE-070705-526	Length:	460	Species:	Danio rerio

Alignment Length:	549	Identity:	104/549 - (18%)
Similarity:	186/549 - (33%)	Gaps:	162/549 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 VWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFA 824
            :.::..|.:.||..|:|....::....:|.:.:.|||.:||.|.|....:..::.        ..
Zfish    25 ILIIGTLGVSGNALVMFAFYSNKKLRSLPNYFIMNLAVSDFLMAITQSPIFFINC--------LY 81

  Fly   825 IPWQMSVL-CQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFA 888
            ..|....| |::..|...|....|:..|..|:::|...||..:...:..|.::.|..:...|:::
Zfish    82 KEWMFGELGCKIYAFCGALFGITSMINLLAISIDRYLVITKPLQTIQWNSKRRTGLAILCIWLYS 146

  Fly   889 LIMALMPLVGVSDY---RKFAVCLPFETTTGPASLTYVISLMFINGCAFL------TLMGCYLKM 944
            |..:|.||:|.|.|   .....|.....:..||:.:|.:.|     |.|:      .::.|||.|
Zfish   147 LAWSLAPLIGWSSYIPEGLMTSCTWDYVSPSPANKSYTMML-----CCFVFFIPLSIILYCYLFM 206

  Fly   945 YWAIRGS----------------QAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLI 993
            :.::|.:                |....::.::||..|:::....|.|:|.|..::.|..|.|.:
Zfish   207 FLSVRQASRDLEMLSSQKSSFVKQQSMRSEWKLAKIAAVVIVVYVLSWAPYACVTLVAWAGHQDV 271

  Fly   994 SLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAVARTKRG 1058
            ....:|.....:...::..|||:|||:..:::
Zfish   272 LTPYSKTLPAVLAKSSAIYNPFIYAIIHNKYR--------------------------------- 303

  Fly  1059 DLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCGENRRRRKQRRQPQQR 1123
                    |......||..||                                          .|
Zfish   304 --------ATLAERVPGLSCL------------------------------------------SR 318

  Fly  1124 RQRAYTAAAANPYQYQFAELRQQRQNRASSISSENFCSSRSSSWRHGPPSSAPVPPGNCSMPLKM 1188
            .|:...:::.|    ..|..:....:|.||:|.....|:              :..|...:.|..
Zfish   319 SQKDGLSSSTN----SDASAQDSSVSRQSSVSKNRLHST--------------MVKGEVELDLME 365

  Fly  1189 LEPHAHPHGHGRRR---HSAWLITRKTSQ-DSNLSSSRND------SSASATTASTSTFR----- 1238
            ..|.....|..|||   .|:.||.:...| ..:||....|      |.|:|....:|..:
Zfish   366 NRPKLSFKGFSRRRLLKCSSLLIEKPPVQMKESLSLCERDLVSGSFSIAAAPMVMSSKQKSRSAD 430

  Fly  1239 LSRSSAGSSTPLPSIIA-------HNGKA 1260
            |..||..|..|:..:::       |.|:|
Zfish   431 LIHSSGDSQNPMQKLLSISQLQQIHEGEA 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	28/128 (22%)
		7tm_1	770..1017	CDD:278431	60/272 (22%)
opn4xb	NP_001245152.1	7tm_4	26..>229	CDD:304433	46/215 (21%)
opn4xb	NP_001245152.1	7tm_1	35..295	CDD:278431	60/272 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910