DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and npffr2a

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001098579.1	Gene:	npffr2a / 560955	ZFINID:	ZDB-GENE-060526-183	Length:	422	Species:	Danio rerio

Alignment Length:	302	Identity:	68/302 - (22%)
Similarity:	133/302 - (44%)	Gaps:	51/302 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 VVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIP 826
            ::||:.::|||.|.|::|.|::...|....:.|||.:|..:||:.....::|....|
Zfish    55 LIFLVCMIGNGVVCFIVLRSKNMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIITG-------- 111

  Fly   827 WQM-SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFAL- 889
            |.. |::|::||.:..:|...||:||..|.::|...|.:.  ..::|::..|.:|:.:.||.|:
Zfish   112 WPFGSMVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYP--FKQKLTISTATFIIVIIWVLAVS 174

  Fly   890 IM----ALMPLVGVSDYRKFA---VCLPF----ETTTGPASLTYVISLMFINGCAFLTLMGCYLK 943
            ||    .::.:....:.|.|.   ...||    |............:::|.|  .:|..:...:.
Zfish   175 IMCPSGVMLQVTKEQNIRVFRGNNRSSPFYWCRENWPNQEMRKIYTTVLFAN--IYLAPLSLIVI 237

  Fly   944 MYWAI----------RGSQAWNTNDSRIAK------RMALLVFTDF-LCWSPIAFFSITAIFGLQ 991
            ||..|          .|.:..:.|...::|      :|.|:|...| |.|.|:  :::..:....
Zfish   238 MYARIGITLFKTAMPAGGKHGHDNRHSVSKKKQRVIKMLLIVALLFILSWLPL--WTLMMLTDYV 300

  Fly   992 LISLEQAKIFTVFVLP-------LNSCCNPFLYAIMTKQFKK 1026
            .::..|.::..:::.|       .||..||.:|....:.|::
Zfish   301 KLTEHQYRVINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRR 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	39/133 (29%)
		7tm_1	770..1017	CDD:278431	64/283 (23%)
npffr2a	NP_001098579.1	7tm_4	57..>184	CDD:304433	39/136 (29%)
npffr2a	NP_001098579.1	7tm_1	63..333	CDD:278431	64/283 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910