DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lrig1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_688817.4	Gene:	lrig1 / 560325	ZFINID:	ZDB-GENE-031113-23	Length:	1022	Species:	Danio rerio

Alignment Length:	453	Identity:	136/453 - (30%)
Similarity:	209/453 - (46%)	Gaps:	77/453 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 HCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIIN 217
            :||.:|:.  ..|..:.:..||.:||...|.|:|.:|.||.::.:.....|:|.|:.|..|
Zfish    35 NCTCTLDT--TDCSRLDMTDVPQDLPKSTVHLNLSHNKLTAVDMDILSNLPHLREVRLDHN---- 93

  Fly   218 MDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRL 282
                                              :|||:...|:|..|: ...|.|..::|  ||
Zfish    94 ----------------------------------ELTSIPSFGDAAASV-VTLLLHHNRIR--RL 121

  Fly   283 EGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLT 347
            ||:|        |.....||.|:|.:|.:|.:.:..||....:..|.|..|:|:.:..||.|||.
Zfish   122 EGSL--------LQNFSALETLDLSNNDITELREHCFPLGLQIKDLHLSSNKIVHLEFGAFKNLA 178

  Fly   348 -ALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRLRWINDTELP--RSMQMLDMRANPLSTIS 408
             :|::|.|..|.::.|| :|| :|.:|.:|.::.||||.|......  .|:::|.::.|.:|.::
Zfish   179 GSLQILRLSRNRLTHLPVKGL-ELPKLTQLELSRNRLRLIEGLTFQGLSSLEVLKLQRNNISKLT 242

  Fly   409 PGAFRGMSKLRKLILSDVRTLR-----SFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
            .|||.|::::|.|.| |..:||     |...||:...|.:.....:.........|.   ||:.|
Zfish   243 DGAFWGLARMRVLHL-DYNSLREVNSGSLYGLESLLQLYLANNSISNFNPEGWGFCE---RLREL 303

  Fly   469 ELKTNSLKRIPNLSSCRDLRL--LDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQD---A 528
            .|..|:|.::...|..:.:.|  |.|..|.|..|....|.||..|..|.|.:|.|....:|   |
Zfish   304 NLSYNNLTKLSEGSFAKLVNLISLRLGHNSISHITEGAFRGLSSLRTLELDHNDISGTIEDTSGA 368

  Fly   529 FQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPEL-PES-----GLRALLHLKT 585
            |.|:..|..|.|.||:|..:.|:||||..|||.||||.|....: ||:     .|| .||:::
Zfish   369 FTGLENLNKLTLFGNKIKSVAKKAFSGLEALEHLNLGENAIRSIQPEAFSKMKNLR-YLHIQS 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	56/204 (27%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	9/59 (15%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	0/22 (0%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	21/60 (35%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	9/23 (39%)
		LRR_RI	327..567	CDD:238064	87/253 (34%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		LRR_8	370..425	CDD:290566	18/56 (32%)
		leucine-rich repeat	372..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	18/72 (25%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	23/62 (37%)
		leucine-rich repeat	487..510	CDD:275380	9/24 (38%)
		leucine-rich repeat	511..534	CDD:275380	9/25 (36%)
		LRR_8	533..589	CDD:290566	25/59 (42%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	11/26 (42%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrig1	XP_688817.4	LRRNT	31..63	CDD:214470	8/29 (28%)
		leucine-rich repeat	63..84	CDD:275380	5/20 (25%)
		LRR_RI	77..334	CDD:238064	83/310 (27%)
		LRR_8	83..142	CDD:290566	25/107 (23%)
		leucine-rich repeat	85..107	CDD:275380	9/59 (15%)
		leucine-rich repeat	108..131	CDD:275380	9/33 (27%)
		LRR_8	132..191	CDD:290566	21/58 (36%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..180	CDD:275380	9/23 (39%)
		leucine-rich repeat	181..203	CDD:275380	9/22 (41%)
		LRR_8	202..262	CDD:290566	19/60 (32%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		LRR_8	251..310	CDD:290566	16/62 (26%)
		leucine-rich repeat	252..275	CDD:275380	8/23 (35%)
		leucine-rich repeat	276..299	CDD:275380	2/25 (8%)
		LRR_8	299..358	CDD:290566	20/58 (34%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	324..347	CDD:275380	9/22 (41%)
		leucine-rich repeat	348..372	CDD:275380	8/23 (35%)
		LRR_4	373..414	CDD:289563	19/40 (48%)
		LRR_8	374..433	CDD:290566	25/58 (43%)
		leucine-rich repeat	375..398	CDD:275380	11/22 (50%)
		leucine-rich repeat	399..420	CDD:275380	9/20 (45%)
		LRRCT	433..481	CDD:214507
		Ig_3	485..572	CDD:290638
		IG_like	492..586	CDD:214653
		I-set	590..680	CDD:254352
		Ig_1	607..681	CDD:143240
		I-set	684..771	CDD:254352
		IGc2	698..761	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910