DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and si:dkey-247m21.3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_017208337.2	Gene:	si:dkey-247m21.3 / 559089	ZFINID:	ZDB-GENE-091204-249	Length:	390	Species:	Danio rerio

Alignment Length:	346	Identity:	80/346 - (23%)
Similarity:	143/346 - (41%)	Gaps:	79/346 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   755 TLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPR--FLVCNLAAADFFMGIYLGILAIVDAATL 817
            ||...:..:.:::.||| .:|.|.||...::...:  |.:.:||.||..:.:.:..||.::..|
Zfish    24 TLSIVLVTIIIMTALGN-LLVMVALCKDRQLRKKKTNFFIVSLAFADLLVALVVMPLAAIELTT- 86

  Fly   818 GEFRMFAIPWQM-SVLCQLSGFLAVLSSELSVYTLAVITLERNYAI--THAIHLNKRLSLKQAGY 879
            |:       |.. ...|.:...|.||.:..|:..|..|.|:|.|||  ...::.||...::.:
Zfish    87 GK-------WNYGETFCLVRTSLDVLLTTASILHLCCIALDRYYAICCQPLVYNNKMTPVRVS-- 142

  Fly   880 IMSVG-WVFALIMALMPL------VGVSDY---RK----------FAVCLPFETTTGPASLTYVI 924
            :|.|| ||....::.:|:      :|:..:   ||          |.|..|:.......:....:
Zfish   143 LMLVGCWVIPFFISFLPIMQSWNTIGIESFIEQRKLNSSRNSTCVFMVNQPYALVCSAVAFYVPL 207

  Fly   925 SLMFI-NGCAFLTLMGCYLKMYWAIR--GSQAWNT-------------NDSRIAKRMALLVFTDF 973
            .||.: ....::|.|| :.:...::.  ||...:|             |:::.||.:|:::....
Zfish   208 VLMVLAYQRIYVTAMG-HARRIGSLHRAGSAPTSTYPNNDQHGSSRIKNETKAAKTLAVIMGCFC 271

  Fly   974 LCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLP------------LNSCCNPFLYAIMTKQFKK 1026
            |||:|   |.:|.:          ...|..:.:|            :||..||||||.:.:.|::
Zfish   272 LCWAP---FFVTNV----------VDPFINYSVPWQMWTAWLWLGYINSGLNPFLYAFLNRAFRR 323

  Fly  1027 D-CVTLCKHFEESRVVGGGGP 1046
            . .:.||...|.....||..|
Zfish   324 AFLMILCCGDERYARQGGFSP 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	36/133 (27%)
		7tm_1	770..1017	CDD:278431	67/299 (22%)
si:dkey-247m21.3	XP_017208337.2	7tmA_5-HT4	23..325	CDD:320184	74/325 (23%)
		TM helix 1	24..50	CDD:320184	9/26 (35%)
		TM helix 2	58..84	CDD:320184	7/25 (28%)
		TM helix 3	96..126	CDD:320184	11/29 (38%)
		TM helix 4	139..162	CDD:320184	6/24 (25%)
		TM helix 5	191..220	CDD:320184	3/28 (11%)
		TM helix 6	254..284	CDD:320184	10/42 (24%)
		TM helix 7	293..318	CDD:320184	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910