DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and lgr4

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001340791.1 Gene:lgr4 / 558825 ZFINID:ZDB-GENE-111013-1 Length:971 Species:Danio rerio


Alignment Length:963 Identity:278/963 - (28%)
Similarity:432/963 - (44%) Gaps:176/963 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 GSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLD 185
            |.|.:.|.......|   |...:|      .|...|..:     |.|.|:.:||..|......||
Zfish    16 GGQAAAAGEGQSTPA---TCSPLC------RCDEDGGAD-----CSGRGLTSVPTGLSAFTYYLD 66

  Fly   186 LGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGL 250
            :..||:|:|.||.|...|.||||.|:.|.:..:.|.|..||.:||.|.|||..||::|..:.:.|
Zfish    67 ISMNNITELPANVFRNLPYLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALKNL 131

  Fly   251 AQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIIN 315
            ..|.||:|:.|.:.|:..|....||:||.|.|:.|....:|.:.|.....|:||.|..|.:|.|.
Zfish   132 NALQSLRLDANHITSVPEDSFEGLQQLRHLWLDDNSLTEVPISPLQHQSNLQALTLALNRITHIP 196

  Fly   316 DEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSN 380
            |..|..:.:|:||.|..|:|.:|.......|..|:.|:|:.|.:...||.:..|.:|:||...||
Zfish   197 DNAFANLSSLVVLHLHNNRIQEIGKNCFNGLDNLETLDLNFNNLKIFPEAIQMLPKLKELGFHSN 261

  Fly   381 RLRWIND-----TELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHA 440
            .:..|.:     ..|.|::.:.|   ||||.:...||:.:|.|..|:|.....::.||.|.....
Zfish   262 NIASIPEGAFCRNSLLRTIHLFD---NPLSFVGTTAFQNLSDLHSLMLRGASMMQDFPSLTGTIN 323

  Fly   441 LEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPF 505
            ||.|.|....|:.:||:||.....|::::|..|.::.:|:                        |
Zfish   324 LESLTLTGTKIRSIPADLCEDLTVLRTVDLSYNDIEDLPS------------------------F 364

  Fly   506 NGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFP 570
            .|..:|.|:.|.:|:||.:.:..|||:..|::|||..|:|.:||::||...:||.:|:|..|...
Zfish   365 QGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSLSALTNLDLSLNSLA 429

  Fly   571 ELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEA 635
            .:|.:||.||..||...|.:||......|.|:::::.:.|||.||||:                 
Zfish   430 SVPTAGLSALNQLKLTGNMELRNGLMSKTLPKLRSITVPYAYQCCAFV----------------- 477

  Fly   636 VLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAIN-FNEEQLQTQTGGQIATSYM 699
                                                  .:::|:| ..:::.:...||:      
Zfish   478 --------------------------------------AYDSAVNPAEDDERRNAFGGE------ 498

  Fly   700 EEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQ--PGSVQCLPMPGPFLPCADLFDWWTLRCGVWV 762
                                        ||.:  |..:.|.|:||.|.||..|...|.:|..||.
Zfish   499 ----------------------------EDMERIPMVMHCSPLPGAFKPCEHLLGSWMIRLTVWF 535

  Fly   763 VFLLSLLGNGTVVFVLLCSR-SKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIP 826
            :.|::||.|..|:......| |.:...||||..||:|:...|:|:..|.::|..|.|.|..:.:.
Zfish   536 ICLVALLFNCLVLAATFSPRTSSLSPSRFLVALLASANLLTGVYVAALTLLDTVTWGSFAEYGVW 600

  Fly   827 WQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVG------W 885
            |:....||:.|||||.|||.:|..||:..:||..|:        |..:.:||.:.|.|      .
Zfish   601 WETGAGCQVVGFLAVFSSEWAVLLLALAAVERCLAV--------RALMGKAGALRSRGERRERRR 657

  Fly   886 VFALIMALMPLVGV-----SDYRKFA----VCLPFETTTGPASLTYVISLMFINGCAFLTLMGCY 941
            .||:...|:.||.|     |.|...|    :||||...:.| .|.:.::|:.:|..|:|.....|
Zfish   658 RFAIAALLLGLVSVAAACLSLYHGSAMGSPLCLPFSEGSSP-GLGFTVALVLMNTLAYLLSAVVY 721

  Fly   942 LKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISL---EQAKIFTV 1003
            .::|..:..:|..:...:...:.:|.|:||:.:.:.|:|.||...:......::   |.||..|:
Zfish   722 TRLYCRLGRAQLADPEQAGSVRHIAWLIFTNCIFFCPVAAFSFAPLLAGTSNAVGGPEMAKSVTL 786

  Fly  1004 FVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGGGPGGRG-AVART 1055
            ...||::|.||.||...:..|:.|.:.|         .|.|..||.| .||:|
Zfish   787 IFFPLSACLNPVLYVCFSPSFRYDWLHL---------RGRGRTGGCGRLVAKT 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 6/20 (30%)
LRR_RI 180..>383 CDD:238064 75/202 (37%)
leucine-rich repeat 183..204 CDD:275380 9/20 (45%)
LRR_8 203..263 CDD:290566 26/59 (44%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 10/22 (45%)
LRR_8 252..311 CDD:290566 21/58 (36%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
LRR_8 299..359 CDD:290566 21/59 (36%)
leucine-rich repeat 301..324 CDD:275380 9/22 (41%)
leucine-rich repeat 325..348 CDD:275380 8/22 (36%)
LRR_RI 327..567 CDD:238064 74/244 (30%)
leucine-rich repeat 349..371 CDD:275380 7/21 (33%)
LRR_8 370..425 CDD:290566 19/59 (32%)
leucine-rich repeat 372..393 CDD:275380 7/25 (28%)
leucine-rich repeat 394..415 CDD:275380 7/20 (35%)
leucine-rich repeat 418..486 CDD:275380 19/67 (28%)
leucine-rich repeat 441..464 CDD:275378 9/22 (41%)
LRR_8 487..545 CDD:290566 16/57 (28%)
leucine-rich repeat 487..510 CDD:275380 2/22 (9%)
leucine-rich repeat 511..534 CDD:275380 9/22 (41%)
LRR_8 533..589 CDD:290566 22/55 (40%)
leucine-rich repeat 535..558 CDD:275380 10/22 (45%)
leucine-rich repeat 559..580 CDD:275380 7/20 (35%)
7tm_4 764..>892 CDD:304433 45/134 (34%)
7tm_1 770..1017 CDD:278431 79/265 (30%)
lgr4NP_001340791.1 LRR 1 58..82 10/23 (43%)
leucine-rich repeat 64..85 CDD:275380 9/20 (45%)
LRR_8 84..144 CDD:316378 26/59 (44%)
LRR 2 84..106 9/21 (43%)
leucine-rich repeat 86..109 CDD:275380 10/22 (45%)
LRR 3 107..130 10/22 (45%)
leucine-rich repeat 110..133 CDD:275380 10/22 (45%)
LRR 4 131..154 8/22 (36%)
leucine-rich repeat 134..157 CDD:275380 8/22 (36%)
LRR 137..>452 CDD:227223 108/341 (32%)
LRR 5 156..178 8/21 (38%)
leucine-rich repeat 158..181 CDD:275380 7/22 (32%)
LRR 6 179..202 9/22 (41%)
leucine-rich repeat 182..205 CDD:275380 9/22 (41%)
LRR 7 204..226 7/21 (33%)
leucine-rich repeat 206..229 CDD:275380 8/22 (36%)
LRR 8 227..250 7/22 (32%)
leucine-rich repeat 230..252 CDD:275380 7/21 (33%)
LRR_8 251..308 CDD:316378 19/59 (32%)
LRR 9 251..273 6/21 (29%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
LRR 10 275..297 9/24 (38%)
leucine-rich repeat 277..298 CDD:275380 8/23 (35%)
LRR 11 299..321 7/21 (33%)
LRR 12 322..344 9/21 (43%)
LRR 13 345..366 5/44 (11%)
leucine-rich repeat 348..369 CDD:275380 6/44 (14%)
LRR 14 367..390 7/22 (32%)
leucine-rich repeat 370..393 CDD:275380 9/22 (41%)
LRR 15 391..414 10/22 (45%)
leucine-rich repeat 394..415 CDD:275380 10/20 (50%)
LRR 16 416..438 8/21 (38%)
leucine-rich repeat 418..438 CDD:275380 7/19 (37%)
7tmA_LGR4 527..811 CDD:320483 89/292 (30%)
TM helix 1 528..554 CDD:320483 8/25 (32%)
TM helix 2 562..587 CDD:320483 10/24 (42%)
TM helix 3 607..637 CDD:320483 16/37 (43%)
TM helix 4 649..679 CDD:320483 8/29 (28%)
TM helix 5 698..727 CDD:320483 8/29 (28%)
TM helix 6 736..766 CDD:320483 8/29 (28%)
TM helix 7 779..804 CDD:320483 11/24 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 84 1.000 Domainoid score I8243
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 384 1.000 Inparanoid score I1997
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171884at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm26229
orthoMCL 1 0.900 - - OOG6_106088
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2481
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.870

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