DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and adrb3a

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001121807.1	Gene:	adrb3a / 558248	ZFINID:	ZDB-GENE-080917-21	Length:	413	Species:	Danio rerio

Alignment Length:	487	Identity:	92/487 - (18%)
Similarity:	159/487 - (32%)	Gaps:	180/487 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 VVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIY---LGILAIVDAATLGEFRMF 823
            ::..::::||..|:..:..:..........:.:||.||..||:.   ||...:|..
Zfish     3 IIITITIVGNLLVIIAIARTSQLQTTTNIFIMSLACADLIMGVLVVPLGATIVVTG--------- 58

  Fly   824 AIPWQM-SVLCQLSGFLAVLSSELSVYTLAVITLERNYAIT----HAIHLNKRLSLKQAGYIMSV 883
              .|:: :..|:|...:.||....|:.||.:|.::|..|||    |.:.|||    .:|..|:.:
Zfish    59 --QWKLNNTFCELWTSVDVLCVTASIETLCIIAVDRYIAITRPLRHKVLLNK----CRARIIVCI 117

  Fly   884 GWVFALIMALMPL------------VGVSDYRKFAVCLPFETTTGPASLTYVIS-------LMFI 929
            .|:.:..::.:|:            |..:.|.. ..|..|.|....|.::.|:|       ::|:
Zfish   118 VWIVSACISFIPIMYGFWRRDPNDDVATACYSD-TNCCDFITNMTYAIISSVVSFYIPLFIMIFV 181

  Fly   930 NGCAFL------------------TLMGCYLK-----------MYWAIRGSQAWNTNDSRIAKRM 965
            ....||                  ..||..::           |...:.|..|...:..|...|:
Zfish   182 YARVFLIATRQVQLIDKNRLRFQNEYMGNQVQPPTIGNNNLPSMCNNVGGMTAKRKSSRRRPSRL 246

  Fly   966 ALL--------------VFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVL-----PLNSC 1011
            .::              |||  |||.|  ||....|:..    :.|.|.|  |.|     .:||.
Zfish   247 TVIKEHKALKTLGIIMGVFT--LCWLP--FFVANIIYAF----VPQDKYF--FRLLNWLGYINSG 301

  Fly  1012 CNPFLYA------------------------IMTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAV 1052
            .||.:|.                        .:.|:|:..|...         :|...||..|:.
Zfish   302 LNPIIYCRSPEFRTAFKNLLACPWIPSIKMNFLYKEFQIRCPCF---------LGSAEPGMSGSF 357

  Fly  1053 ARTKRGDLPPPLLPAAAVAHPPGCRCLRMLP---SEMPNWHKMEQTPSMWQRLRTFCCGENRRRR 1114
            .:       ||..|.|             ||   |...::...|.:|.
Zfish   358 QK-------PPTSPDA-------------LPEDGSSQSSYRSEEPSPG----------------- 385

  Fly  1115 KQRRQPQQRRQRAYTAAAANPYQYQFAELRQQ 1146
                 |.......:.:..:.| :.:|:.|::|
Zfish   386 -----PPHSNGSTFFSEISEP-ETEFSNLQEQ 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	32/135 (24%)
		7tm_1	770..1017	CDD:278431	70/321 (22%)
adrb3a	NP_001121807.1	7tm_1	11..307	CDD:278431	70/321 (22%)
adrb3a	NP_001121807.1	7tm_4	11..>141	CDD:304433	33/144 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910