DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and chrm5a

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001018639.1	Gene:	chrm5a / 553978	ZFINID:	ZDB-GENE-080723-32	Length:	490	Species:	Danio rerio

Alignment Length:	555	Identity:	88/555 - (15%)
Similarity:	165/555 - (29%)	Gaps:	241/555 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 VVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIP 826
            :|..::::||..|:.....:.....|..:.:.:||.||..:|::          ::..:..:.:.
Zfish    34 IVSFITIIGNILVMLSFKVNSQLKTVNNYYLLSLAFADLIIGVF----------SMNLYTSYILM 88

  Fly   827 --WQM-SVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFA 888
              |.: |:.|.|...|..::|..||..|.||:.:|.::||..:....:.:.|.||.::.:.|:.:
Zfish    89 GYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKIAGIMIGLAWLVS 153

  Fly   889 LIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQA 953
            .|:                                                      ||
Zfish   154 FIL------------------------------------------------------WA------ 158

  Fly   954 WNTNDSRIAKRMALLVFTDFLCWS-------------PIAFFSITAI-FGLQLISLEQAKIFTVF 1004
                             ...|||.             .|.|||...| ||..:    .|..|.|.
Zfish   159 -----------------PPILCWQYFVGKRTVPERQCQIQFFSEPVITFGTAI----AAFYFPVS 202

  Fly  1005 VLPLNSCCNPFLYAIMTKQFK---KDCVTL-----------------------CKHFEESRVVGG 1043
            |:.:       ||.::.|:.:   ||...|                       |||
Zfish   203 VMTI-------LYCLIYKETERRTKDLAELQGINSSTNSSGDAQPQKIRSCFGCKH--------- 251

  Fly  1044 GGPGGRGAVARTKRGDLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCG 1108
                    |:.|.|         ..|::|   ....:.|..::.|::
Zfish   252 --------VSNTSR---------TQALSH---TNAAKTLDDQLTNFN------------------ 278

  Fly  1109 ENRRRRKQRRQPQQRRQRAYTAAAANPYQYQFAELRQQRQNRASSISSENFCSSRSSSWRHGPPS 1173
                              :|.::........|.|..:.::|::.|...|||..:        |..
Zfish   279 ------------------SYASSEEEDRSGNFQESCRHQENKSESYEEENFFPT--------PVK 317

  Fly  1174 SAPVPPGNCSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSNLSSSRNDSSASATTASTSTFR 1238
            ::|.....| :..|.                      |....|.|.::..|:...|::.|::...
Zfish   318 ASPTKTKKC-VSYKF----------------------KPKDVSPLKNTNGDAKPGASSFSSAESV 359

  Fly  1239 LSRSSAGSSTPLPSIIAHNGKAQLDAVKPRLVRQE 1273
            .:.||:.||.|:...:    |.|:...|..::.:|
Zfish   360 NAPSSSSSSKPIDGTL----KCQITKRKRMVLIKE 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	28/130 (22%)
		7tm_1	770..1017	CDD:278431	44/263 (17%)
chrm5a	NP_001018639.1	7tm_4	34..>167	CDD:304433	34/219 (16%)
chrm5a	NP_001018639.1	7tm_1	42..448	CDD:278431	87/547 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910