DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and zgc:113307

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001018560.1	Gene:	zgc:113307 / 553753	ZFINID:	ZDB-GENE-050522-29	Length:	343	Species:	Danio rerio

Alignment Length:	405	Identity:	97/405 - (23%)
Similarity:	148/405 - (36%)	Gaps:	119/405 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 LDLGNNNLTKLEANSFFMAPNLEELTLSDN------SIINMD------------PNAFY------ 224
            ||.|.   ..|..|.|...|::  |||.|.      ..:|..            |.|.|
Zfish     3 LDYGG---VPLWINRFLGEPSV--LTLKDRIDPGWYRAVNTQSCPLECDCPIQWPTAIYCDHRGL 62

  Fly   225 -----GLA-KLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVS--LDGDCLGHLQKLRTLR 281
                 ||. :|:.|.||...:.||..::|.....|..|.|:.|.|:|  ||......|.:|..|.
Zfish    63 NQLPSGLPFRLQYLFLQGNNITSLGSRAFDNTTYLRWLILDHNELLSEQLDNVLFSSLTRLVNLF 127

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            :..|...::|....:||:   .|.|..|.:..|::.||..:.:|.::||:.|::..|..|..|.|
Zfish   128 INHNNLTKVPAGLPSGLK---QLRLAYNHIEKISEGDFQNLDSLTLILLQGNRLKTIEEGDFKGL 189

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGA 411
            .||.:|:|..|.:.:.|:                        .||.|:|.|.:..|.|:.:|..:
Zfish   190 GALNLLDLSHNFLDTFPK------------------------HLPPSVQQLYLSNNSLTGLSENS 230

  Fly   412 FRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLK 476
            ....|.||.|                                          ||...:|:...|.
Zfish   231 LHAFSGLRYL------------------------------------------RLGHNKLRNERLD 253

  Fly   477 RIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAF------QGIPKL 535
              |...:...|..||||.|::.:|...|..    |..|.|..|.|:.....:|      ....::
Zfish   254 --PGAFNLTSLVELDLSYNRLTEIPSVPIT----LQYLYLEVNHIQEFNVSSFCRTVGPTSYSRM 312

  Fly   536 QLLDLEGNEISYIHK 550
            ::|.|:||::.| ||
Zfish   313 KILRLDGNKLEY-HK 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	59/230 (26%)
		leucine-rich repeat	183..204	CDD:275380	6/19 (32%)
		LRR_8	203..263	CDD:290566	22/89 (25%)
		leucine-rich repeat	205..228	CDD:275380	10/52 (19%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	18/60 (30%)
		leucine-rich repeat	253..276	CDD:275380	9/24 (38%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	51/230 (22%)
		leucine-rich repeat	349..371	CDD:275380	5/21 (24%)
		LRR_8	370..425	CDD:290566	12/54 (22%)
		leucine-rich repeat	372..393	CDD:275380	2/20 (10%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	8/67 (12%)
		leucine-rich repeat	441..464	CDD:275378	0/22 (0%)
		LRR_8	487..545	CDD:290566	18/63 (29%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	6/28 (21%)
		LRR_8	533..589	CDD:290566	7/18 (39%)
		leucine-rich repeat	535..558	CDD:275380	7/16 (44%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
zgc:113307	NP_001018560.1	LRRNT	41..70	CDD:214470	4/28 (14%)
		leucine-rich repeat	56..72	CDD:275380	3/15 (20%)
		LRR_RI	<60..274	CDD:238064	67/284 (24%)
		LRR_8	72..133	CDD:290566	19/60 (32%)
		leucine-rich repeat	73..96	CDD:275380	7/22 (32%)
		leucine-rich repeat	97..122	CDD:275380	9/24 (38%)
		leucine-rich repeat	123..146	CDD:275380	6/25 (24%)
		LRR_8	142..200	CDD:290566	20/60 (33%)
		leucine-rich repeat	147..167	CDD:275380	6/19 (32%)
		leucine-rich repeat	168..191	CDD:275380	8/22 (36%)
		leucine-rich repeat	192..212	CDD:275380	7/43 (16%)
		LRR_8	211..272	CDD:290566	21/104 (20%)
		leucine-rich repeat	213..236	CDD:275380	5/22 (23%)
		leucine-rich repeat	237..261	CDD:275380	8/67 (12%)
		leucine-rich repeat	282..311	CDD:275380	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910