DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and LGR4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_060960.2	Gene:	LGR4 / 55366	HGNCID:	13299	Length:	951	Species:	Homo sapiens

Alignment Length:	881	Identity:	265/881 - (30%)
Similarity:	414/881 - (46%)	Gaps:	107/881 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.|.   .|:.|.|.|:.|||..|......||:..||:|:|..::|...|.||||.|:.|.:.
Human    33 CSCDGD---RRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLS 94

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:.|.|..||.:||.|:|||..||::|.::.:||:.|.||:|:.|.:.|:..|....|.:||.|.
Human    95 FIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLW 159

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |:.|....:|.:.|:.|.||:||.|..|.::.|.|..|..:.:|:||.|..|:|..:|......|
Human   160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGL 224

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWIND-----TELPRSMQMLDMRANPLST 406
            ..|:.|:|:.|.:...|:.:..|..|:||...||.:..|.|     ..|.|::.:.|   ||||.
Human   225 DNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYD---NPLSF 286

  Fly   407 ISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELK 471
            :...||..:|.|..|::.....::.||.|.....||.|.|....|..:|.|||::...|::|:|.
Human   287 VGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLS 351

  Fly   472 TNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQ 536
            .|:::.:|:.:.|..|..:.|..|||.:|:                        :..|||:..|:
Human   352 YNNIRDLPSFNGCHALEEISLQRNQIYQIK------------------------EGTFQGLISLR 392

  Fly   537 LLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFP 601
            :|||..|.|..||..||:....:.:|::..|.....|..||..|..||...|.||:|......|.
Human   393 ILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFV 457

  Fly   602 RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQ 666
            .:::|.:.|||.||||                    :..|:..::...:||:     |.|:::::
Human   458 NLRSLSVPYAYQCCAF--------------------WGCDSYANLNTEDNSL-----QDHSVAQE 497

  Fly   667 LGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQ 731
            .|.:      .|.|              .||.:|.  |||...
Human   498 KGTA------DAAN--------------VTSTLEN--EEHSQI---------------------- 518

  Fly   732 PGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLA 796
              .:.|.|..|.|.||..|...|.:|..||.:||::|..|..|:.....|.:.:...:..:..::
Human   519 --IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLIS 581

  Fly   797 AADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYA 861
            .::.|||||.|||..:||.:.|.|..|.|.|:....|:::|||||.|||.:::.|.:.|:||:.:
Human   582 VSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLS 646

  Fly   862 ITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISL 926
            ....:...|...|||......:.::.|.:....||....:|....:||||.|...| ||.:.::|
Human   647 AKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETP-SLGFTVTL 710

  Fly   927 MFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQ 991
            :.:|..|||.:...|.|:|..:........:.|.:.|.:|.|:||:.:.:.|:||||...:....
Human   711 VLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 775

  Fly   992 LISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKD 1027
            .||.|..|..|:...||.:|.||.||.....:||:|
Human   776 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/20 (40%)
		LRR_RI	180..>383	CDD:238064	73/202 (36%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	27/59 (46%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	11/22 (50%)
		LRR_8	252..311	CDD:290566	22/58 (38%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	21/59 (36%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	70/244 (29%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	19/59 (32%)
		leucine-rich repeat	372..393	CDD:275380	8/25 (32%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	20/67 (30%)
		leucine-rich repeat	441..464	CDD:275378	9/22 (41%)
		LRR_8	487..545	CDD:290566	14/57 (25%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	18/55 (33%)
		leucine-rich repeat	535..558	CDD:275380	10/22 (45%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	39/127 (31%)
		7tm_1	770..1017	CDD:278431	76/246 (31%)
LGR4	NP_060960.2	LRRNT	29..56	CDD:279764	10/25 (40%)
		LRR_RI	<44..239	CDD:238064	72/194 (37%)
		LRR 1	58..79		7/20 (35%)
		leucine-rich repeat	59..82	CDD:275380	7/22 (32%)
		LRR 2	82..103		8/20 (40%)
		LRR_8	83..141	CDD:290566	26/57 (46%)
		leucine-rich repeat	83..106	CDD:275380	10/22 (45%)
		LRR 3	106..127		9/20 (45%)
		leucine-rich repeat	107..130	CDD:275380	11/22 (50%)
		LRR 4	130..151		7/20 (35%)
		LRR_8	131..189	CDD:290566	22/57 (39%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR 5	154..177		7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR_8	177..237	CDD:290566	21/59 (36%)
		LRR 6	178..199		9/20 (45%)
		leucine-rich repeat	179..202	CDD:275380	8/22 (36%)
		LRR 7	202..223		7/20 (35%)
		leucine-rich repeat	203..226	CDD:275380	8/22 (36%)
		LRR_RI	221..426	CDD:238064	65/231 (28%)
		LRR 8	226..247		5/20 (25%)
		leucine-rich repeat	227..249	CDD:275380	6/21 (29%)
		LRR_8	248..305	CDD:290566	19/59 (32%)
		LRR 9	249..270		7/20 (35%)
		leucine-rich repeat	250..273	CDD:275380	7/22 (32%)
		LRR 10	273..294		9/23 (39%)
		leucine-rich repeat	274..295	CDD:275380	8/23 (35%)
		LRR 11	320..341		9/20 (45%)
		LRR 12	344..365		5/20 (25%)
		LRR_8	345..401	CDD:290566	20/79 (25%)
		leucine-rich repeat	345..366	CDD:275380	6/20 (30%)
		LRR 13	366..387		7/44 (16%)
		leucine-rich repeat	367..390	CDD:275380	9/46 (20%)
		LRR_8	390..444	CDD:290566	18/53 (34%)
		LRR 14	390..411		10/20 (50%)
		leucine-rich repeat	391..414	CDD:275380	10/22 (45%)
		LRR 15	414..435		5/20 (25%)
		leucine-rich repeat	415..438	CDD:275380	6/22 (27%)
		leucine-rich repeat	439..461	CDD:275380	7/21 (33%)
		7tm_1	556..801	CDD:278431	76/245 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8814
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2595
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41437
orthoMCL	1	0.900	-	-		OOG6_106088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730