DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AVPR1A

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_000697.1	Gene:	AVPR1A / 552	HGNCID:	895	Length:	418	Species:	Homo sapiens

Alignment Length:	387	Identity:	75/387 - (19%)
Similarity:	142/387 - (36%)	Gaps:	121/387 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   746 PCADLFDWWTLRCG---------------------------------VWVVFLLSLLGNGTVVFV 777
            |..:...||.|..|                                 :.|.|.:::|||.:|:..
Human    11 PSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLA 75

  Fly   778 LLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGE------FRMFAIPWQMSVLCQLS 836
            |..:..|.......:.:|:.||         ||:.....|.:      :|.....|    ||::.
Human    76 LHRTPRKTSRMHLFIRHLSLAD---------LAVAFFQVLPQMCWDITYRFRGPDW----LCRVV 127

  Fly   837 GFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLS--LKQAGYIMSVGWVFALIMA-----LM 894
            ..|.|.....|.|.|.|:|.:|..|:.|.:   |.|.  .:::..:::..||.:.:::     :.
Human   128 KHLQVFGMFASAYMLVVMTADRYIAVCHPL---KTLQQPARRSRLMIAAAWVLSFVLSTPQYFVF 189

  Fly   895 PLVGVSDYRKFAVCLPFETTTGP----ASLTYVISLMFINGCAFLTLMG-CY----LKMYWAIRG 950
            .::.|::..|...|  :.|...|    |.:|::...:|:   |.:.::| ||    ..::..:||
Human   190 SMIEVNNVTKARDC--WATFIQPWGSRAYVTWMTGGIFV---APVVILGTCYGFICYNIWCNVRG 249

  Fly   951 SQAWNTNDSRIAK---------------------------------RMALLVFTDFL-CWSPIAF 981
            ..|     ||.:|                                 :|..::.|.:: ||:|...
Human   250 KTA-----SRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFI 309

  Fly   982 FSITAIFGLQLISLEQAK---IFTVFVLPLNSCCNPFLYAIMTKQFKKDCV---TLCKHFEE 1037
            ..:.:::....:..|...   ..|..:..|||||||::|...:....:|||   ..|::.:|
Human   310 IQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKE 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	31/135 (23%)
		7tm_1	770..1017	CDD:278431	61/305 (20%)
AVPR1A	NP_000697.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		5/31 (16%)
		7tmA_V1aR	52..359	CDD:320507	65/332 (20%)
		TM helix 1	53..79	CDD:320507	7/25 (28%)
		TM helix 2	86..113	CDD:320507	6/35 (17%)
		TM helix 3	124..154	CDD:320507	10/29 (34%)
		TM helix 4	166..187	CDD:320507	2/20 (10%)
		TM helix 5	213..242	CDD:320507	7/31 (23%)
		TM helix 6	284..314	CDD:320507	5/29 (17%)
		TM helix 7	327..352	CDD:320507	9/24 (38%)
		DUF1856	372..418	CDD:312513	75/387 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910