DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and ASPN

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_060150.4	Gene:	ASPN / 54829	HGNCID:	14872	Length:	379	Species:	Homo sapiens

Alignment Length:	297	Identity:	80/297 - (26%)
Similarity:	138/297 - (46%)	Gaps:	45/297 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|...:    :.|..:|:.:||.|:|.:..:|||.||.:.:::.|.|....:|..|.|::|.:.
Human    78 CQCYSRV----VHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLT 138

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLP---PQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLR 278
            .:.|.||....||:||.|.:..|..:|   |:|      |..|:::.|.:..:..|....:..|.
Human   139 KIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKS------LAELRIHENKVKKIQKDTFKGMNALH 197

  Fly   279 TLRLEGN----------------LFY-RIP----TNALAGL-RTLEALNLGSNLLTIINDEDFPR 321
            .|.:..|                :|: ||.    |:...|| .||..|:|..|.::.:..|||.|
Human   198 VLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKR 262

  Fly   322 MPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLR--W 384
            ...|..|.|..|:|..|..|:|.|:..::.:.|::|.:..:|.||.:|..||.:.:.||.:.  .
Human   263 YKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVG 327

  Fly   385 IND-----TELPRSM-QMLDMRANPLS--TISPGAFR 413
            :||     .::.:|: ..:.:..||:.  .:.|..||
Human   328 VNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFR 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	64/227 (28%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	19/62 (31%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	8/25 (32%)
		LRR_8	252..311	CDD:290566	18/80 (23%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	9/44 (20%)
		LRR_8	299..359	CDD:290566	20/59 (34%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	26/97 (27%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	12/54 (22%)
		leucine-rich repeat	372..393	CDD:275380	6/27 (22%)
		leucine-rich repeat	394..415	CDD:275380	5/23 (22%)
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
ASPN	NP_060150.4	LRRNT	73..103	CDD:214470	8/28 (29%)
		leucine-rich repeat	83..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		LRR_8	104..161	CDD:290566	19/56 (34%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		LRR_RI	<142..339	CDD:238064	55/202 (27%)
		leucine-rich repeat	151..171	CDD:275380	7/19 (37%)
		leucine-rich repeat	172..195	CDD:275380	4/22 (18%)
		leucine-rich repeat	196..221	CDD:275380	3/24 (13%)
		LRR_8	240..300	CDD:290566	20/59 (34%)
		leucine-rich repeat	242..265	CDD:275380	8/22 (36%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	313..332	CDD:275380	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910