DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Avpr1a

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_058543.2	Gene:	Avpr1a / 54140	MGIID:	1859216	Length:	423	Species:	Mus musculus

Alignment Length:	374	Identity:	73/374 - (19%)
Similarity:	134/374 - (35%)	Gaps:	107/374 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   745 LPCADLFDWWTL----------RCGVW-----------------------VVFLLSLLGNGTVVF 776
            ||..:...||.|          ..|:.                       |:|::::|||.:|:.
Mouse    10 LPAGNSSPWWPLTTEGANSSREAAGLGEGGSPPGDVRNEELAKLEVTVLAVIFVVAVLGNSSVLL 74

  Fly   777 VLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAV 841
            .|..:..|.......:.:|:.||..:..:..:..:....|   :|.....|    ||::...|.|
Mouse    75 ALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDIT---YRFRGPDW----LCRVVKHLQV 132

  Fly   842 LSSELSVYTLAVITLERNYAITHAIHLNKRLS--LKQAGYIMSVGWVFALIMALMPLVGVSDYRK 904
            .:...|.|.|.|:|.:|..|:.|.:   |.|.  .:::..:::..|..:.:::      :..|..
Mouse   133 FAMFASSYMLVVMTADRYIAVCHPL---KTLQQPARRSRLMIAASWGLSFVLS------IPQYFI 188

  Fly   905 FAVCLPFETTTGP----------------ASLTYVISLMFINGCAFL-TLMG--CYLKMYWAIRG 950
            |:| :.||...|.                |.:|::.|.:|:.....| |..|  || .::..:||
Mouse   189 FSV-IEFEVNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGFICY-HIWRNVRG 251

  Fly   951 SQAWNTNDS--------------------------------RIAKRMALLVFTDFLCWSPIAFFS 983
            ..|...:..                                |..|...::|....|||:|.....
Mouse   252 KTASRQSKGGKGSGEAAGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWTPFFIVQ 316

  Fly   984 ITAIFGLQLI---SLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCV 1029
            :.:::....:   |...:...|..:..|||||||::|...:....:|||
Mouse   317 MWSVWDTNFVWTDSENPSTTITALLASLNSCCNPWIYMFFSGHLLQDCV 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	28/129 (22%)
		7tm_1	770..1017	CDD:278431	60/302 (20%)
Avpr1a	NP_058543.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		5/12 (42%)
		7tm_4	62..>259	CDD:304433	46/214 (21%)
		7tm_1	68..353	CDD:278431	60/302 (20%)
		DUF1856	377..423	CDD:286120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910