DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and islr2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001013541.1	Gene:	islr2 / 541396	ZFINID:	ZDB-GENE-050320-95	Length:	712	Species:	Danio rerio

Alignment Length:	591	Identity:	132/591 - (22%)
Similarity:	208/591 - (35%)	Gaps:	161/591 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 KHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNS 214
            |.|.|:.......:.|....::.|||.||:....|.|..|.:..|::.:|.....:..|.|:.|.
Zfish    24 KQCACSDKYNHQFVDCAYKDLVEVPVGLPSNASTLSLSANKIKVLKSKTFVNVTQVTSLWLAHNE 88

  Fly   215 IINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRT 279
            ||.::.:....|.:||.|.:.|..:...|.:....|..|..|::|.|.:||:..:...:|:.||:
Zfish    89 IITVERDTLAPLIQLKNLDISNNKIVHFPWEDLANLGALQLLKMNNNEMVSIPKNAFSNLKDLRS 153

  Fly   280 LRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMK--ISAGA 342
            :|:..|.|..|.......|..:..|.:..|        .|....||..|   |:.|:|  ||...
Zfish   154 IRINNNKFTTIVQGTFDSLAAMSHLQIFHN--------PFICSCNLEWL---RDWILKSSISIPE 207

  Fly   343 LKNLTALKVLELDDNLISSLPEGLSKLS-QLQELSIT--SNRLRWINDTELPRS-MQML--DMRA 401
            ..|:.......|..:.::|:|    ||: :...:|||  .|    |..|||... |.||  :.:.
Zfish   208 QNNIACDAPSHLKGSQVTSMP----KLNCKAPSVSITYQPN----IEKTELYEGYMVMLYCETKG 264

  Fly   402 NPLSTISPGAFRG----------------------------------------MSKLRK-----L 421
            .|...::...|.|                                        |||..:     .
Zfish   265 TPKPEVTWEIFAGNQLITFPLPAIVEKSDIPINGPPTNTRFLVFQNGTLIVPRMSKKEEGNYTCS 329

  Fly   422 ILSDVRTLRSFPELEAC----HALE---------ILKLDRAGIQEVPANLCRQTPRLKSLELKTN 473
            .::|:....|...|...    ||..         :|..|:.|.:....::....|:   .|.||.
Zfish   330 AVNDIGKAESSVRLVVAGTKKHATNSMLDTKSPGLLPEDKLGSKGSKNSVISMRPK---FEEKTK 391

  Fly   474 SLKRIPNLSSCRDLRLLDLSSNQI-EKIQGKPFNGLKQLND---------LLLSYNRIKALPQDA 528
            ||   |..:|     ::.:...|: |.....||.|...:||         ..||.:.:|....|.
Zfish   392 SL---PTGTS-----VITVDKEQVDEGADTLPFVGKCGINDGTQYISNHAFNLSLDELKQYTFDF 448

  Fly   529 FQGIPKLQLLDLE----------GNEISYIH-----------KEAFSGF------TALEDLNL-- 564
              |:..|::.:.|          .|..|.||           ||.||.|      :.|:.|.|
Zfish   449 --GVIALEVSETEAKVQLNPMQMANAKSNIHLSQQQDLQTVNKEPFSLFQTSAKKSPLDLLYLCV 511

  Fly   565 ----GNNIFP-ELPESGLRA--LLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVA 622
                |:::.. ...|.|:.|  ..|||...|               .||.|:|....|..  .|.
Zfish   512 STGNGHSVVQWSKIEEGVNAYRFQHLKPGTN---------------YTLCLTYGGQDCQV--QVV 559

  Fly   623 MSSQKK 628
            .:::||
Zfish   560 FTTRKK 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	52/207 (25%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	16/59 (27%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..311	CDD:290566	16/58 (28%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	13/61 (21%)
		leucine-rich repeat	301..324	CDD:275380	3/22 (14%)
		leucine-rich repeat	325..348	CDD:275380	8/24 (33%)
		LRR_RI	327..567	CDD:238064	72/348 (21%)
		leucine-rich repeat	349..371	CDD:275380	5/22 (23%)
		LRR_8	370..425	CDD:290566	17/105 (16%)
		leucine-rich repeat	372..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..415	CDD:275380	6/62 (10%)
		leucine-rich repeat	418..486	CDD:275380	16/85 (19%)
		leucine-rich repeat	441..464	CDD:275378	3/31 (10%)
		LRR_8	487..545	CDD:290566	15/77 (19%)
		leucine-rich repeat	487..510	CDD:275380	5/23 (22%)
		leucine-rich repeat	511..534	CDD:275380	7/31 (23%)
		LRR_8	533..589	CDD:290566	21/91 (23%)
		leucine-rich repeat	535..558	CDD:275380	11/49 (22%)
		leucine-rich repeat	559..580	CDD:275380	7/29 (24%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
islr2	NP_001013541.1	leucine-rich repeat	35..53	CDD:275380	5/17 (29%)
		LRR_RI	<47..>184	CDD:238064	38/144 (26%)
		LRR_8	53..113	CDD:290566	15/59 (25%)
		leucine-rich repeat	57..78	CDD:275380	5/20 (25%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		LRR_8	102..161	CDD:290566	17/58 (29%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		leucine-rich repeat	127..150	CDD:275380	7/22 (32%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		LRRCT	183..>221	CDD:214507	12/48 (25%)
		IG_like	252..345	CDD:214653	12/92 (13%)
		Ig	256..345	CDD:299845	11/88 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910