DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Chrm5

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_059058.1	Gene:	Chrm5 / 53949	RGDID:	620027	Length:	531	Species:	Rattus norvegicus

Alignment Length:	663	Identity:	115/663 - (17%)
Similarity:	191/663 - (28%)	Gaps:	274/663 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   725 MSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPR 789
            |..|.:...:|...|:....|....|::..|:.....||.|::::||..|:.....:.....|..
  Rat     1 MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNN 65

  Fly   790 FLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAI--PWQM-SVLCQLSGFLAVLSSELSVYTL 851
            :.:.:||.||..:||:          ::..:..:.:  .|.: |:.|.|...|..::|..||..|
  Rat    66 YYLLSLACADLIIGIF----------SMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNL 120

  Fly   852 AVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTG 916
            .||:.:|.::||..:....:.:.|:||.::.:.|:.:.|:
  Rat   121 LVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFIL------------------------- 160

  Fly   917 PASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWS---- 977
                                         ||                       ...|||.
  Rat   161 -----------------------------WA-----------------------PAILCWQYLVG 173

  Fly   978 ---------PIAFFS-ITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLC 1032
                     .|.|.| .|..||..:         ..|.:|:         ::||       :..|
  Rat   174 KRTVPPDECQIQFLSEPTITFGTAI---------AAFYIPV---------SVMT-------ILYC 213

  Fly  1033 KHFEESRVVGGGGPGGRGAVARTK-RGDLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTP 1096
            :.:.|:.             .||| ..||......|.|....|..|.|
  Rat   214 RIYRETE-------------KRTKDLADLQGSDSVAEAKKREPAQRTL----------------- 248

  Fly  1097 SMWQRLRT-FCCGENRRRRKQRRQPQQRRQRAYTAAAANPYQYQFAELRQQRQNRASSISSE--- 1157
                 ||: |.|......:::|.|......|..|:...             :..:|:.:|::
  Rat   249 -----LRSFFSCPRPSLAQRERNQASWSSSRRSTSTTG-------------KTTQATDLSADWEK 295

  Fly  1158 ----NFCSSRSSSWRHGPPSSAPVPPGNCSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSNL 1218
                ..|||..||.....|::.||                            :.:..|:....:.
  Rat   296 AEQVTTCSSYPSSEDEAKPTTDPV----------------------------FQMVYKSEAKESP 332

  Fly  1219 SSSRNDSSASATTASTSTFRLSRSSAGSSTP---LPSIIAHNGKAQ-LDAVKPRL-VRQEAVQEE 1278
            ....|......|..:|.|     .::...||   |....||..|:| ..|.|.|| |:.:..||.
  Rat   333 GKESNTQETKETVVNTRT-----ENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQET 392

  Fly  1279 EDSSPPRLGVRFLPTIPSAADSSVVMEDGDSANTGVASFLGMPLPGASSGFLIAPTTAATTSPPP 1343
            .:      |.|.:..:|                   .||                         |
  Rat   393 NN------GCRKVKIMP-------------------CSF-------------------------P 407

  Fly  1344 VVLQPAKPPPDPN 1356
            |...|:...||||
  Rat   408 VSKDPSTKGPDPN 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	30/130 (23%)
		7tm_1	770..1017	CDD:278431	42/263 (16%)
Chrm5	NP_059058.1	7tm_4	39..>166	CDD:304433	33/213 (15%)
		7tm_1	46..255	CDD:278431	59/355 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..295		6/48 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..346		2/18 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910