DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Tlr5

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_017177186.1	Gene:	Tlr5 / 53791	MGIID:	1858171	Length:	873	Species:	Mus musculus

Alignment Length:	614	Identity:	149/614 - (24%)
Similarity:	246/614 - (40%)	Gaps:	141/614 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 EVLRLSCRGIG-ILAVPVNLPNEVVVLDLGNN--NLTKLEANSFFMAPNLEELTLSDNSIINMDP 220
            |.|.||...|. ::|....|...:.:|:||..  ||| :...:|...|||..|.|..:.|..::.
Mouse    64 ERLLLSFNYISMVVATSFPLLERLQLLELGTQYANLT-IGPGAFRNLPNLRILDLGQSQIEVLNR 127

  Fly   221 NAFYGLAKLKRLSLQNCGLKS--LPPQSFQGLAQLTSLQLNGNALVSL-------------DGD- 269
            :||.||..|..|.|.:|||.|  |....|:.|..|..|.|:||.:.||             |.:
Mouse   128 DAFQGLPHLLELRLFSCGLSSAVLSDGYFRNLYSLARLDLSGNQIHSLRLHSSFRELNSLSDVNF 192

  Fly   270 --------CLGHLQKL--RTLRLEG----NLFYRIPT------NALAGLRTLEALNLGSNLLTII 314
                    |...|:.|  :||...|    .||.|:..      |...|:| ||.|:|..|..|:.
Mouse   193 AFNQIFTICEDELEPLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGVR-LETLDLSENGWTVD 256

  Fly   315 NDEDFPRM--PNLIVLLLKRNQIMKISAG----------ALKNLTALKVLELD--DNLISSL-PE 364
            ...:|..:  .:.|..|:.::.||....|          ...:|....||:||  ...|.|| |.
Mouse   257 ITRNFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPR 321

  Fly   365 GLSKLSQLQELSITSNRLRWINDTEL--PRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVR 427
            ....|..|:.|::..|::..|.:...  ..|:|:|::..|.|..:....|.|:.::
Mouse   322 LFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRV--------- 377

  Fly   428 TLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRL--- 489
               ::.:|:..|         .||  :.....|....|::|:|:.|:||.|..:.|.:.:.|
Mouse   378 ---AYVDLQRNH---------IGI--IQDQTFRLLKTLQTLDLRDNALKAIGFIPSIQMVLLGGN 428

  Fly   490 --------------LDLSSNQIEKIQGKPF-NGLKQLNDLLLSYNRIKA---------------- 523
                          |:||.|::|.:....| ..:.||..|:|:.||:.:
Mouse   429 KLVHLPHIHFTANFLELSENRLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSENPSLEQL 493

  Fly   524 --------------LPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPE 574
                          |..|.|||:.:||:|.|..|.::::....|:...||..|:|..|....|..
Mouse   494 FLTENMLQLAWETGLCWDVFQGLSRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKLTVLSP 558

  Fly   575 SGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSY-AYHC-CAFLPLVAMSSQKKTSQVQEAVL 637
            ..|.|.|.:...:..:|.. |.|..|..::.|.::: .:.| |.....::..:|...:      |
Mouse   559 GSLPANLEILDISRNQLFS-PDPALFSSLRVLDITHNEFVCNCELSTFISWLNQTNVT------L 616

  Fly   638 FPSDAEFDMTLWNNSMMNIWPQMHNLSKQ 666
            |.|.|:. ..::.||::.  ..::|:|.:
Mouse   617 FGSPADV-YCMYPNSLLG--GSLYNISTE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	72/255 (28%)
		leucine-rich repeat	183..204	CDD:275380	7/22 (32%)
		LRR_8	203..263	CDD:290566	25/61 (41%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	10/24 (42%)
		LRR_8	252..311	CDD:290566	25/92 (27%)
		leucine-rich repeat	253..276	CDD:275380	10/44 (23%)
		leucine-rich repeat	277..300	CDD:275380	9/34 (26%)
		LRR_8	299..359	CDD:290566	18/73 (25%)
		leucine-rich repeat	301..324	CDD:275380	7/24 (29%)
		leucine-rich repeat	325..348	CDD:275380	6/32 (19%)
		LRR_RI	327..567	CDD:238064	66/302 (22%)
		leucine-rich repeat	349..371	CDD:275380	9/24 (38%)
		LRR_8	370..425	CDD:290566	11/56 (20%)
		leucine-rich repeat	372..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	13/67 (19%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	23/105 (22%)
		leucine-rich repeat	487..510	CDD:275380	7/40 (18%)
		leucine-rich repeat	511..534	CDD:275380	10/52 (19%)
		LRR_8	533..589	CDD:290566	15/55 (27%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Tlr5	XP_017177186.1	leucine-rich repeat	63..93	CDD:275380	8/28 (29%)
		LRR_8	<101..146	CDD:338972	15/44 (34%)
		leucine-rich repeat	112..135	CDD:275380	8/22 (36%)
		leucine-rich repeat	136..161	CDD:275380	10/24 (42%)
		leucine-rich repeat	162..186	CDD:275380	7/23 (30%)
		leucine-rich repeat	187..242	CDD:275380	12/54 (22%)
		leucine-rich repeat	243..304	CDD:275380	13/60 (22%)
		leucine-rich repeat	305..328	CDD:275380	9/22 (41%)
		LRR_8	308..363	CDD:338972	15/54 (28%)
		leucine-rich repeat	329..352	CDD:275380	4/22 (18%)
		LRR_8	352..411	CDD:338972	16/81 (20%)
		leucine-rich repeat	353..376	CDD:275380	6/22 (27%)
		leucine-rich repeat	377..400	CDD:275380	5/45 (11%)
		PRK15370	<397..>597	CDD:185268	46/200 (23%)
		leucine-rich repeat	401..429	CDD:275380	9/27 (33%)
		leucine-rich repeat	430..464	CDD:275380	6/33 (18%)
		leucine-rich repeat	465..489	CDD:275380	5/23 (22%)
		leucine-rich repeat	490..518	CDD:275380	5/27 (19%)
		leucine-rich repeat	519..542	CDD:275380	6/22 (27%)
		leucine-rich repeat	543..561	CDD:275380	5/17 (29%)
		leucine-rich repeat	565..585	CDD:275380	5/20 (25%)
		PCC	569..>647	CDD:188093	16/84 (19%)
		TIR	708..858	CDD:366714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910