DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Lingo4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001102659.1	Gene:	Lingo4 / 499668	RGDID:	1562025	Length:	618	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	137/544 - (25%)
Similarity:	197/544 - (36%)	Gaps:	139/544 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VNRTSKSASVTPTGIRENVMLPSADPEKEAQILYEK--SLQEYHGSQLSTASTATDVIAGKRTLH 141
            :.|.|......|..:|...| .:|...|:|.:|:..  .|....|..:|:..|.
  Rat     7 LERCSAQLDAFPQLLRPQGM-DAATAPKQAWLLWSPLLFLLLLPGGSISSCPTL----------- 59

  Fly   142 SICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLE 206
                      |.||.....:..:.|.:.  .||..||.:..||||..|.|..|:.........|:
  Rat    60 ----------CDCTSQTRAVLCAHRRLD--TVPGGLPLDTEVLDLSGNRLWGLQRGMLSRLGQLQ 112

  Fly   207 ELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCL 271
            ||.||.|.:..::|.||:||..|..|.||...|:.:.|..|.||:.||.|.|..|.:|
  Rat   113 ELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLSALTLLDLRLNQIV------- 170

  Fly   272 GHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIM 336
                    |.|:|         |...|.:|:.|.:|.|.|..:....|..:..|..:.|:|..:.
  Rat   171 --------LFLDG---------AFGELGSLQQLEVGDNHLVFVAPGAFSGLAKLSTITLERCNLS 218

  Fly   337 KISAGALKNLTALKVLELDDNLISSLPEG-LSKLSQLQELSITSNRLRWINDTELPRSMQMLDMR 400
            .:...||..|.||..|.|.:..|..||.| |..|.||:||.|.    .|       .|::.||
  Rat   219 TVPGLALAQLPALVALRLRELDIERLPSGALRGLGQLKELEIH----HW-------PSLEALD-- 270

  Fly   401 ANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRL 465
                    ||:..|::                        |..|.:....:..||
  Rat   271 --------PGSLVGLN------------------------LSSLAITHCNLSSVP---------- 293

  Fly   466 KSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQ 530
                     .:.:.:||.   |::||||.|.|..|..:..:.|.:|.:|.||...:.::...||.
  Rat   294 ---------FQALHHLSF---LQVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFH 346

  Fly   531 GIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKT---------- 585
            |:....|||:..|.:..:.:.||.....|..|.|..|  |...:..|..||.|:.
  Rat   347 GLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGN--PLTCDCRLLWLLRLRRRLDFGTSPPA 409

  Fly   586 ------FNNPKLREFP---PPDTF 600
                  .....||||.   ||..|
  Rat   410 CAGPQHVQGKNLREFSDILPPGHF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	65/203 (32%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	25/59 (42%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	15/58 (26%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	16/59 (27%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	58/240 (24%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		LRR_8	370..425	CDD:290566	12/54 (22%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	6/67 (9%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	15/71 (21%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lingo4	NP_001102659.1	leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		LRR_8	88..145	CDD:290566	22/56 (39%)
		LRR_4	88..126	CDD:289563	13/37 (35%)
		LRR_RI	110..345	CDD:238064	84/325 (26%)
		leucine-rich repeat	111..134	CDD:275380	11/22 (50%)
		LRR_8	134..193	CDD:290566	24/82 (29%)
		leucine-rich repeat	135..158	CDD:275380	9/22 (41%)
		leucine-rich repeat	159..182	CDD:275380	11/46 (24%)
		LRR_8	182..237	CDD:290566	15/54 (28%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		leucine-rich repeat	255..302	CDD:275380	16/110 (15%)
		LRR_8	278..334	CDD:290566	18/101 (18%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		LRR_8	326..385	CDD:290566	17/60 (28%)
		leucine-rich repeat	327..348	CDD:275380	6/20 (30%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		IG_like	445..526	CDD:214653
		Ig	456..526	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910